Effects of thiazolidine-4(R)-carboxylates and other low-molecular-weight sulfur compounds on the activity of mercaptopyruvate sulfurtransferase, rhodanese and cystathionase in Ehrlich ascites tumor cells and tumor-bearing mouse liver

Amino Acids

Volumn 12, Issue 3-4, 1997, Pages 309-314

  Wrobel M ^a   Wlodek L ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Amino acids; Cystathionase Ehrlich ascites tumor cell; Mercaptopyruvate sulfurtransferase; Mouse liver; Rhodanese; Thiazolidine 4(R) carboxylates

Indexed keywords

CYSTATHIONINE GAMMA LYASE; CYSTEINE; METHIONINE; SULFUR DERIVATIVE; SULFURTRANSFERASE; THIAZOLIDINE DERIVATIVE; THIOSULFATE; THIOSULFATE SULFURTRANSFERASE; TIMONACIC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EHRLICH ASCITES TUMOR CELL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; LIVER METABOLISM; LIVER TUMOR; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0030846499     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01373011     Document Type: Article

References (19)

1. Fletcher JC, Robson A (1963) The occurence of bis-(2-amino-2-carboxyethyl) trisulphide in hydrolyasates of wool and other proteins. Biochem J 87: 553-559
2. Jackson JF, Morse FA (1970) Desulfurase activity and chromosome analysis of cultured rat hepatomas cells. Rev Eur Elud Clin Biol 15: 906-910
3. Kasperczyk A, Koj A, Wasylewski Z (1977) Similarity of some molecular and catalytic parameters of mitochondrial and cytosolic mercaptopyruvate sulphurtransferase from rat liver. Bull Acad Pol Biol 25: 7-13
4. Koj A, Frendo J, Borysiewicz J (1964) Cysteine desulfhydrase and rhodanese activity in cells of tissue cultures and in transplantable tumours. Acta Med Pol 2: 109-117
5. Kun E, Fanshier DW (1959) Isolation and properties of betamercaptopyruvate-cleaving copper enzyme. Biochim Biophys Acta 32: 328-348
6. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
7. Matsuo Y, Greenberg DM (1958) A crystalline enzyme that cleaves homoserine and cystathionine. J Biol Chem 230: 545-560
8. Nagasawa HT, Good DJW, Muldoon WP, Zera RT (1984) 2-Substituted thiazolidine-4-(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity. J Med Chem 27: 591-596
9. Schubert MP (1936) Compounds of thiol acids with aldehydes. J Biol Chem 114: 341-350
10. Sörbo B (1955) Rhodanese. Methods in enzymology, vol 2. Academic Press, New York, pp 334-337
11. Sprinson DB, Chargaff E (1946) A study of β-hydroksy-α-keto acids. J Biol Chem 164: 417-432
12. Toohey JI (1989) Sulphane sulphur in biological systems: a possible regulatory role. Biochem J 264: 625-632
13. Włodek L (1984) Formation of 2-methyl-2,4-thiazolidinecarboxylic acid from L-cysteine in rat tissues. Acta Biochim Pol 31: 279-288
14. Włodek L (1988) The reaction of sulfhydryl groups with carbonyl compounds. Acta Biochim Pol 35: 307-317
15. Włodek L, Szczepkowski T, Buczulska L (1971) The induction of rhodanese and cystathionase activities in regular and neoplastic tissues. Folia Biol (Kraków) 19: 449-455
16. Włodek L, Wróbel M, Czubak L (1993a) Transamination and transsulphuration of L-cysteine in Ehrlich ascites tumor cells and mouse liver. The non-enzymatic reaction of L-cysteine with pyruvate. Int J Biochem 25: 107-112
17. Włodek L, Rommelspacher H, Susilo R, Radomski J, Hofle G (1993b) Thiazolidine derivatives as source of free L-cysteine in rat tissue. Biochem Pharmacol 46: 1917-1928
18. Włodek L, Radomski J, Wróbel M (1993c) The effect of 2-substituted thiazolidine-4(R)-carboxylic acids on non-protein sulphydryl levels and sulphurtransferase activities in mouse liver and brain. Biochem Pharmacol 46: 190-193
19. Wróbel M, Frendo J (1992) The effect of cAMP and some sulphur compounds upon the activity of mercaptopyruvate sulphurtransferase and rhodanese in mouse liver. Folia Biol (Kraków) 40: 11-14