Adenovirus-mediated β-galactosidase gene delivery to the liver leads to protein deposition in kidney glomeruli

Kidney International

Volumn 52, Issue 4, 1997, Pages 992-999

  Zhu, Guoming ^a   Nicolson, A Graham ^a   Zheng, Xin Xiao ^a   Strom, Terry B ^a   Sukhatme, Vikas P ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Adenovirus; Gene transfer; Liver; Protein transfer; galactosidase gene

Indexed keywords

BETA GALACTOSIDASE;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GENE TARGETING; GENE TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 0030846270     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.421     Document Type: Article

References (24)

1. YANG Y, LI O, ERH HC, WILSON JM: Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol 69:2004-2015, 1995
2. DAI Y, SCHWARTZ EM, GU D, ZHANG WW, SARVETNICK NZ, VERMA IM: Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: Tolerization of factor IX and vector antigen allows for long-term expression. Proc Natl Acad Sci USA 92:1401-1405, 1995
3. DEMATTEO RP, MARKMANN JF, KOZARSKY KF, BARKER CF, RAPER SE: Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion. Gene Therapy 3:4-12, 1996
4. HERZ J, GERARD RD: Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 90:2823-2826, 1993
5. BONNEROT C, ROCANCOUNT D, BRIAUD P. GRIMBER G, NICOLAS J-F: A β-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies. Proc Natl Acad Sci USA 84:6795-6799, 1987
6. ANTON M, GRAHAM FL: Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase: A molecular switch for control of gene expression. J Virology 69:4600-4606, 1995
7. ZHU G, NICOLSON AG, COWLEY BD JR, ROSEN S, SUKHATME VP: In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys. Gene Therapy 3:298-304, 1996
8. PANOSKALTSIS-MORTARI A, BUCY RP: In situ hyridiation with diboxigenin-labeled RNA probes: Facts and artifacts. Biotech 18:300-307, 1995
9. STEURER W, NICKERSON PW, STEELE AW, STEIGER J, ZHENG XX, STROM TB: Ex vivo coating of islet cell allografts with murine CTLA41FL promotes graft tolerance. J Immunol 155:1165-1174, 1995
10. KAY MA, HOLTERMAN AX, MEUSE L, GOWN A, OCHS HD, LINSLEY PS, WILSON CB: Long-term hepatic adenovirus-mediated gene expression in mice CTLA4Ig administration. Nature Genet 11:191-197, 1995
11. MANNIK M: Mechanisms of tissue deposition of immune complexes. J Rheumatol 14(Suppl 13):35-42, 1987
12. ENDO Y, KANBAYASHI H: Etiology of IgA nephropathy syndrome. Pathol Int 44:1-13, 1994
13. GAUTHIER VJ, MANNIK M: A small portion of cationic antibodies in immune complexes is sufficient to mediate their deposition in glomeruli. J Immunol 145:3348-3352, 1990
14. BORDER WA, KAMIL ES, WARD HJ, COHEN AH: Antigenic charges as a determinant of immune complex localization in the rat glomerulus. Lab Invest 40:442-449, 1981
15. BATSFORD SR, TAKAMIYA N, VOGT A: A model of in situ complex glomerularitis in the rat, employing cationized ferrin. Clin Nephrol 14:211-216, 1980
16. COHEN AH, BORDER WA, GLASSOCK RJ: Nephrotic syndrome with mesangial IgM deposits. Lab Invest 38:610-619, 1978
17. ELEMA JD, HOYER J, VERNIER RL: The glomerular mesangium; uptake and transport of intravenously injected colloid carbon in the rat. Kidney Int 9:395-406, 1976
18. JACOBSON RH, MATTHEW BW: Crystallization of β-galactosidase from Escherichia coli. J Mol Biol 223:1177-1182, 1992
19. RHODES JM, BLOM J: Cytochemical localization of beta-galactosidase in resident and inflammatory peritoneal macrophages from C57BL mice. Histochem 86:159-164, 1986
20. TENU J-P, VIRATELLE OM, GARNIER J, YON J: pH dependence of the activity of β-galactosidase from Escherichia coli. Eur J Biochem 20:363-370, 1971
21. TOMITA N, HIGAKI J, MORISHITA R, KATO K, MIKAMI H, KANEDA Y, OGIHARA T: Direct. in vivo gene introduction into rat kidney Biochem Biophys Res Commun 186:129-134, 1992
22. KITAMURA M, TAYLOR S, UNWIN R, BURTON S, SHIMIZU F, FINE LG: Gene transfer into the rat renal glomerulus via a mesangial cell vector: Site-specific delivery in situ amplification and sustained expression of an exogenous gene in vivo. J Clin Invest 94:497-505, 1994
23. HEIKKILA P, PARPALA T, LUKKARINEN O, WEBER M, TRYGGVASON K: Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney prefusion system-first step towards gene therapy of Alport syndrome. Gene Therapy 3:21-27, 1996
24. ISAKA Y, BREES DK, IKEGAYA K, KANEDA Y, IMAI E, NOBLE NA, BORDER WA: Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nature Med 2:418-423, 1996