Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: Quantitative models for cellular radiation damage

Radiation Research

Volumn 148, Issue 3, 1997, Pages 272-284

  Newton, Gerald L ^a   Aguilera, Joseph A ^b   Ward, John F ^b   Fahey, Robert C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTAMINE; DISULFIDE; GLUTATHIONE; POLYAMINE; PUTRESCINE; SPERMIDINE;

ARTICLE; CELL DAMAGE; DNA DETERMINATION; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; MINICHROMOSOME; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RADIATION INJURY; RADIATION PROTECTION; RADIOSENSITIVITY;

CYSTAMINE; DISULFIDES; DNA DAMAGE; DNA, SINGLE-STRANDED; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; GLUTATHIONE; HETEROCYCLIC COMPOUNDS; MERCAPTOETHYLAMINES; MODELS, GENETIC; POLYAMINES; PUTRESCINE; RADIATION-PROTECTIVE AGENTS; SIMIAN VIRUS 40; SPERMIDINE; SPERMINE; SULFHYDRYL COMPOUNDS;

PICA;

EID: 0030845279     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579612     Document Type: Article

References (61)

1. L. Willson, Free radical repair mechanisms and the interactions of glutathione. In Radioprotectors and Anticarcinogens (O. F. Nygaard and M. G. Simic, Eds.), pp. 1-22. Academic Press, New York, 1983.
2. C. von Sonntag, The Chemical Basis of Radiation Biology, Chapter 10. Taylor & Francis, London, 1987.
3. E. A. Bump and J. M. Brown, Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol. Ther. 47, 117-136 (1990).
4. S. Zheng, G. L. Newton, G. Gonick, R. C. Fahey and J. F. Ward, Radioprotection of DNA by thiols: Relationship between the net charge on a thiol and its ability to protect DNA. Radiat. Res. 114, 11-27 (1988).
5. R. C. Fahey, K. M. Prise, M. R. L. Stratford, R. R. Watfa and B. D. Michael, Rates for repair of pBR322 radicals by thiols as measured by the gas explosion technique: Evidence that counter-ion condensation and co-ion depletion are significant at physiological tonic strength. Int. J. Radiat. Biol. 59, 901-917 (1991).
6. S. Zheng, G. L. Newton, J. F. Ward and R. C. Fahey, Aerobic radioprotection of pBR322 by thiols: Effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat. Res. 130, 183-193 (1992).
7. G. D. Smoluk, R. C. Fahey and J. F. Ward, Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiat. Res. 107, 194-204 (1986).
8. G. D. Smoluk, R. C. Fahey and J. F. Ward, Interaction of glutathione and other low molecular weight thiols with DNA: Evidence for counterion condensation and coion depletion. Radiat. Res. 114, 3-10 (1988).
9. J. A. Aguilera, G. L. Newton, R. C. Fahey and J. F. Ward, Thiol uptake by V-79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiat. Res. 130, 194-204 (1992).
10. K. M. Prise, N. E. Gillies, A. Whelan, G. L. Newton, R. C. Fahey and B. D. Michael, Role of charge in the radioprotection of E. coli by thiols. Int. J. Radiat. Biol. 67, 393-401 (1995).
11. N. L. Oleinick, U. Balasubramaniam, L. Xue and S. Chiu, Nuclear structure and the microdistribution of radiation damage in DNA. Int. J. Radiat. Biol. 66, 523-529 (1994).
12. M. Ljungman, The influence of chromatin structure on the frequency of radiation-induced DNA strand breaks: A study using nuclear and nucleoid monolayers. Radiat. Res. 126, 58-64 (1991).
13. R. L. Warters and B. W. Lyons, Variation in radiation-induced formation of DNA double-strand breaks as a function of chromatin structure. Radiat. Res. 130, 309-318 (1992).
14. J. Nygren, M. Ljungman and G. Ahnström, Chromatin structure and radiation-induced DNA strand breaks in human cells: Soluble scavengers and DNA-bound proteins offer a better protection against single-than double-strand breaks. Int. J. Radiat. Biol. 68, 11-18 (1995).
15. J. R. Milligan, J. A. Aguilera and J. F. Ward, Variation of single-strand break yield with scavenger concentration for the SV40 minichromosome irradiated in aqueous solution. Radiat. Res. 133, 158-162 (1993).
16. K. D. Held and S. Awad, Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA. Int. J. Radiat. Biol. 59, 699-710 (1991).
17. M. Spotheim-Maurizot, S. Ruis, R. Sabattier and M. Charlier, Radioprotection of DNA by polyamines. Int. J. Radiat. Biol. 68, 571-577 (1995).
18. G. L. Newton, J. A. Aguilera, J. F. Ward and R. C. Fahey, Polyamine-induced compaction and aggregation of DNA - A major factor in radiation of chromatin under physiological conditions. Radiat. Res. 145, 776-780 (1996).
19. L. C. Gosule and J. A. Schellman, Compact form of DNA induced by spermidine. Nature 259, 333-335 (1976).
20. L. C. Gosule and J. A. Schellman, DNA condensation with polyamines. I. Spectrosocopic studies. J. Mol. Biol. 121, 311-326 (1978).
21. R. W. Wilson and V. A. Bloomfield, Counterion-induced condensation of deoxyribonucleic acid. A light-scattering study. Biochemistry 18, 2192-2196 (1979).
22. D. Porschke, Dynamics of DNA condensation. Biochemistry 23, 4821-4828 (1984).
23. D. Sen and D. M. Crothers, Condensation of chromatin: Role of multivalent cations. Biochemistry 25, 1495-1503 (1986).
24. V. A. Bloomfield, Condensation of DNA by multivalent cations: Considerations on mechanism. Biopolymers 31, 1471-1481 (1991).
25. F. Mark, U. Becker, J. N. Herak and D. Schulte-Frohlinde, Radiolysis of DNA in aqueous solution in the presence of a scavenger: A kinetic model based on a nonhomogeneous reaction of OH radicals with DNA molecules of spherical and cylindrical shape. Radiat. Environ. Biophys. 28, 81-99 (1989).
26. L. Udovičić, F. Mark and E. Bothe, Yields of single-strand breaks in double-stranded calf thymus DNA irradiated in aqueous solution in the presence of oxygen and scavengers. Radiat. Res. 140, 166-171 (1994).
27. P. M. Calabro-Jones, J. A. Aguilera, J. F. Ward, G. D. Smoluk and R. C. Fahey, Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug. Cancer Res. 48, 3634-3640 (1988).
28. J. R. Milligan, J. A. Aguilera and J. F. Ward, Variation of single-strand break yield with scavenger concentration for plasmid DNA irradiated in aqueous solution. Radiat. Res. 133, 151-157 (1993).
29. P. Oudet, E. Weiss and E. Regnier, Preparation of simian virus 40 minichromosomes. Meth. Enzymol. 170, 14-25 (1989).
30. S. G. Swarts, M. D. Sevilla, D. Becker, C. T. Tokar and K. T. Wheeler, Radiation-induced DNA damage as a function of hydradon. I. Release of unaltered bases. Radiat. Res. 145, 304-314 (1992).
31. D. Becker and M. D. Sevilla, The chemical consequences of radiation damage to DNA. In Advances in Radiation Biology, Vol. 17 (J. T. Lett and W. K. Sinclair, Eds.), pp. 121-180. Academic Press, San Diego, 1993.
32. E. S. Henle, R. Roots, W. R. Holley and A. Chatterjee, DNA strand breakage is correlated with unaltered base release after gamma irradiation. Radiat. Res. 143, 144-150 (1995).
33. F. Busi, M. D'Angelantonio, G. Bettoli, V. Concialini, O. Tubertini and G. C. Barker, Study of highly reactive inorganic intermediates using a fast coulostatic technique. Inorg. Chim. Acta 84, 105-111 (1984).
34. M. Abramowitz and I. A. Stegun, Eds., Handbook of Mathematical Functions with Formulas, Graphs, and Mathematical Tables, pp. 355-494. National Bureau of Standards Applied Mathematics Series 55, Dover, New York, 1970.
35. -) in aqueous solution. J. Phys. Chem. Ref. Data 17, 513-886 (1988).
36. 125I induced DNA double strand breaks: Use in calibration of the neutral filter elution technique and comparison with X-ray induced breaks. Int. J. Radiat. Biol. 48, 555-566 (1985).
37. D. Blöcher, DNA double-strand breaks in Ehrilch ascites tumour cells at low doses of X-rays. I. Determination of induced breaks by centrufugation at reduced speed. Int. J. Radiat. Biol. 42, 317-328 (1982).
38. D. Blöcher, In CHEF electrophoresis a linear induction of dsb corresponds to a nonlinear fraction of extracted DNA with dose. Int. J. Radiat. Biol. 57, 7-12 (1990).
39. D. D. Ager and W. C. Dewey, Calibration of pulsed field gel electrophoresis for measurement of DNA double-strand breaks. Int. J. Radiat. Biol. 58, 249-259 (1990).
40. 125I decay. Int. J. Radiat. Biol. 59, 343-357 (1991).
41. H. A. Sober, Ed., CRC Handbook of Biochemistry, p. H13. The Chemical Rubber Co., Cleveland, 1970.
42. W. Keller, U. Müller, I. Eicken, I. Wendel and H. Zentgraf, Biochemical and ultrastructural analysis of SV40 chromatin. Cold Spring Harbor Symp. Quant. Biol. 42, 227-243 (1977).
43. J. Widom. Toward a unified model of chromatin folding. Annu. Rev. Biophys. Biophys. Chem. 18, 365-395 (1989).
44. C. W. Tabor and H. Tabor, 1,4-Diaminobutane (putrescine), spermidin, and spermine. Annu. Rev. Biochem. 45, 285-306 (1976).
45. A. E. Pegg and P. P. McCann, Polyamine metabolism and function. Am. J. Physiol. 243, C212-C221 (1982).
46. S. Sarhan and N. Seiler, On the subcellular localization of the polyamines. Biol. Chem. Hoppe-Seyler 370, 1279-1284, (1989).
47. P. Celano, S. B. Baylin and R. A. Casero, Jr., Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells. J. Biol. Chem. 264, 8922-8927 (1989).
48. A. Prager, N. H. A. Terry and D. Murray, Influence of intracellular thiol and polyamine levels on radioprotection by aminothiols. Int. J. Radiat. Biol. 64, 71-81 (1993).
49. G. E. Plum, P. G. Arscott and V. A. Bloomfield, Condensation of DNA by trivalent cations. 2. Effects of cation structure. Biopolymers 30, 631-643 (1990).
50. U. Klimczak, D. C. Ludwig, F. Mark, P. Rettbert and D. Schulte-Frohlinde, Irradiation of plasmid and phage DNA in water-alcohol mixtures: Strand breaks and lethal damage as a function of scavenger concentration. Int. J. Radiat. Biol. 64, 497-510 (1993).
51. R. E. Krisch, M. B. Flick and C. N. Trumbore, Radiation chemical mechanisms of single-and double-strand break formation in irradiated SV40 DNA. Radiat. Res. 126, 251-259 (1991).
52. 4He ions. Radiat. Res. 136, 190-196 (1993).
53. L. Halmer and C. Gruss, Effects of cell cycle dependent histone H1 phosphorylation on chromatin structure and chromatin replication. Nucleic Acids Res. 24, 1420-1427 (1996).
54. G. L. Newton, J. A. Aguilera, J. F. Ward and R C. Fahey, Binding of radioprotective thiols and disulfides in V79 cell nuclei. Radiat. Res. 146, 298-305 (1996).
55. •OH formation. Radiat. Res. 145, 673-680 (1996).
56. W. Saenger, Water and nucleic acids. In Principles of Nucleic Acid Structure (C. R. Cantor. Ed.), pp. 368-384. Springer-Verlag, New York, 1984.
57. P. M. Cullis, G. D. D. Jones, M. C. R. Symons and J. S. Lea, Electron transfer from protein to DNA in irradiated chromatin. Nature 330, 773-774 (1987).
58. P. M. Cullis, G. D. D. Jones, J. Lea, M. C. R. Symons and M. Weeney, The effects of ionizing radiation on deoxyribonucleic acid. Part 5. The role of thiols in chemical repair. J. Chem. Soc. Perkin Trans. II, 1907-1914 (1987).
59. D. Becker, S. Summerneid, S. Gillich and M. D. Sevilla, Influence of oxygen on the repair of direct radiation damage to DNA by thiols in model systems. Int. J. Radiat. Biol. 65, 537-548 (1994).
60. L. Y. Xue, L. R. Friedman, N. L. Oleinick and S. M. Chiu, The induction of DNA damage in γ-irradiated nuclei stripped of nuclear protein classes: Differential modulation of double-strand break and DNA-protein crosslink formation. Int. J. Radiat. Biol. 66, 11-21 (1994).
61. M. Mach, P. Ebert, R. Popp and A. Ogilvie, Compartmentalization of polyamines in mammalian cells. Biochem. Biophys. Res. Commun. 104, 1327-1334 (1982).