Substituted 2,3-dihydroisoxazoles (Δ4-isoxazolines) via palladium- mediated cyclization of propargylic N-hydroxyureas

Tetrahedron Letters

Volumn 38, Issue 28, 1997, Pages 4981-4984

  Stoner, Eric J ^a   Roden, Brian A ^a   Chemburkar, Sanjay ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 [5 (4 FLUOROPHENOXY) 2 FURYL] 1 METHYL 2 PROPYNYL] 1 HYDROXYUREA; HYDROXYUREA; ISOXAZOLINE DERIVATIVE; LIPOXYGENASE INHIBITOR; PALLADIUM; SILICA GEL; ZILEUTON;

ARTICLE; ASTHMA; CATALYST; CYCLIZATION; ENTERITIS; GEL CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RHEUMATOID ARTHRITIS;

EID: 0030844850     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01080-0     Document Type: Article

References (24)

1. Commercially available as Zyflo™.
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23. 4OH to facilitate the removal of palladium and copper salts. The crude product is then isolated by extraction with ethyl acetate or a similar solvent. In all cases, the crude products were purified by column chromatography.
24. Prepared from 2-iodothiophene and 4 as described in references 2e and 5.