The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non-invasive bioengineering methods. A model to select the potentially most effective product

Contact Dermatitis

Volumn 36, Issue 6, 1997, Pages 297-301

  Mortz, Charlotte G ^a   Andersen, Klaus E ^a   Halkier Sorensen, Lars ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Chlorhexidine; Dermatitis; Electrical conductance; Emollients; Hairless mice; Moisturizers; Prevention; Skin barrier; Skin temperature; Therapy; Transepidermal water loss (TEWL)

Indexed keywords

ACETONE; CHLORHEXIDINE; EMOLLIENT AGENT; WATER OIL CREAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; NUDE MOUSE; SKIN CONDUCTANCE; SKIN FUNCTION; SKIN WATER LOSS;

ACETONE; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CELL MEMBRANE PERMEABILITY; CHLORHEXIDINE; DERMATITIS, IRRITANT; DERMATOLOGIC AGENTS; DISEASE MODELS, ANIMAL; EMOLLIENTS; FEMALE; GALVANIC SKIN RESPONSE; MICE; MICE, INBRED HRS; SKIN; SKIN TEMPERATURE; TIME FACTORS; WATER LOSS, INSENSIBLE;

EID: 0030844737     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0536.1997.tb00004.x     Document Type: Article

References (17)

1. Blichmann C W, Serup J, Winther A. Effects of single application of a moisturizer: evaporation of emulsion water, skin surface temperature, electrical conductance, electrical capacitance and skin surface (emulsion) lipids. Acta Dermato-venereologica 1989: 69: 327-330.
2. Serup J, Winther A, Blichmann C W. Effect of repeated application of a moisturizer. Acta Dermato-venereologica 1989: 69: 457-459.
3. Korstanje C, Ligtvoet F P T, Van Hemert K H F. Differential effects of dermatological cream bases with respect to skin surface moisturizing capacity: a study design in volunteers. J Dermatol Treat 1992: 2: 137-139.
4. Grove G L. The effect of moisturizers on skin surface hydration as measured in vivo by electrical conductivity. Current Therapeutic Research 1991: 50: 712-719.
5. Andersen K E. Reproducibility of the chamber scarification test. Contact Dermatitis 1996: 34: 181-184.
6. Menon G K, Feingold K R, Moser A H, Brown B E, Elias P M. De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res 1985: 26: 418-427.
7. Halkier-Sørensen L. Occupational skin diseases. Contact Dermatitis 1996: suppl 1: 1-120.
8. Grubauer G, Elias P M, Feingold K R. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res 1989: 30: 323-334.
9. Halkier-Sørensen L, Thestrup-Pedersen K. The efficacy of a moisturizer (Locobase) among cleaners and kitchen assistants during everyday exposure to water and detergents. Contact Dermatitis 1993: 29: 1-6.
10. Mann M Q, Feingold K R, Elias P M. Exogenous lipids influence permeability barrier recovery in acetone-treated murin skin. Arch Dermatol 1993: 129: 728-738.
11. Goh C L, Gan S L. Efficacies of a barrier cream and an afterwork emollient cream against cutting fluid dermatitis in metalworkers: a prospective study. Contact Dermatitis 1994: 31: 176-180.
12. Frosch P, Schulze-Dirks A, Hoffmann M et al. Efficacy of skin barrier creams (I). The repetitive irritation test (RIT) in the guinea pig. Contact Dermatitis 1993: 28: 94-100.
13. Frosch P, Schulze-Dirks A, Hoffmann M, Axthelm I. Efficacy of skin barrier creams (II). Ineffectiveness of a popular "skin protector" against various irritants in the repetitive irritation test in guinea pig. Contact Dermatitis 1993: 29: 74-77.
14. Frosch P, Kurte A, Pilz B. Efficacy of skin barrier creams (III). The repetitive irritation test (RIT) in humans. Contact Dermatitis 1993: 29: 113-118.
15. Frosch P, Kurte A. Efficacy of skin barrier creams. (IV). The repetitive irritation test (RIT) with a set of 4 standard irritants. Contact Dermatitis 1994: 31: 161-168.
16. Welzel J, Wilhelm K P, Wolff H H. Skin permeability barrier and occlusion: no delay of repair in irritated human skin. Contact Dermatitis 1996: 35: 163-168.
17. Ghadially R, Halkier-Sørensen L, Elias P M. Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol 1992: 26: 387-396.