Sensitization of multidrug-resistant human leukemia cells with MDR1-targeted antisense and inhibition of drug-mediated MDR1 induction

Leukemia

Volumn 11, Issue 7, 1997, Pages 950-957

  Li, X ^a   Smyth, A P ^a   Barrett, D J ^a   Ivy, S P ^b   Von Hofe, E ^a  

^a HYBRIDON INC   (United States)

^b CHILDREN S RESEARCH INSTITUTE   (United States)

Author keywords

Hybrid antisense; MRK16 antibody; P glycoprotein

Indexed keywords

ANTIBODY; ANTIINFECTIVE AGENT; ANTISENSE OLIGONUCLEOTIDE; CYCLOSPORIN; DAUNORUBICIN; GLYCOPROTEIN P; MONOCLONAL ANTIBODY; PHOSPHOROTHIOIC ACID; RHODAMINE 123; VERAPAMIL; VINCRISTINE;

ARTICLE; DNA RNA HYBRIDIZATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SENSITIZATION; STAINING;

EID: 0030844628     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400696     Document Type: Article

References (11)

1. Gottesman MM. How cancer cells evade chemotherapy: Sixteenth Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res 1993; 53: 747-754.
2. Harrison DJ. Molecular mechanisms of drug resistance in tumours. J Pathol 1995; 175: 7-12.
3. Willman CL Immunophenotyping and cytogenetics in older adults with acute myeloid leukemia: significance of expression of the multidrug resistance gene-1 (MDR1). Leukemia 1996; 10 (Suppl. 1): S33-S35.
4. Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993; 62: 385-427.
5. Bellamy WT, Dalton WS. Multidrug resistance in the laboratory and clinic. Adv Clin Chem 1994; 31: 1-61.
6. Sikic BI. Modulation of multidrug resistance: at the threshold. J Clin Oncol 1993; 11: 1629-1635.
7. Clynes M, Heenan M, Hall K. Human cell lines as models for multidrug resistance in solid tumours. Cytotechnology 1993; 12: 231-256.
8. Ueda K, Cardarelli C, Gottesman MM et al. Expression of a fulllength cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubucin, and vinblastine. Proc Natl Acad Sci USA 1987; 84: 3004-3008.
9. Mickisch GH, Licht T, Merlino GT et al. Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity. Cancer Res 1991; 51: 5417-5424.
10. Chin K-V, Tanaka S, Darlington G et al. Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem 1990; 265: 221-226.
11. Thorgeirsson SS, Huber BE, Sorrell S et al. Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science 1987; 236: 1120-1122.