Effect of acute N-nitro-L-arginine methyl ester (L-NAME) hypertension on glucose tolerance, insulin levels, and [3H]-deoxyglucose muscle uptake

American Journal of Hypertension

Volumn 10, Issue 6, 1997, Pages 683-686

  Bursztyn, Michael ^a   Raz, Itamar ^a   Mekler, Judith ^a   Ben Ishay, Drori ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Glucose tolerance; Hypertension; Insulin resistance; Muscle blood flow; N nitro L arginine methyl ester (L NAME)

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLUCOSE TOLERANCE; HEMODYNAMIC MONITORING; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; MUSCLE BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

ANIMALS; DEOXYGLUCOSE; GLUCOSE; GLUCOSE TOLERANCE TEST; HYPERTENSION; INSULIN; MUSCLE, SKELETAL; NG-NITROARGININE METHYL ESTER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030844626     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(97)00058-7     Document Type: Article

References (29)

1. Modan M, Halkin H, Almog S, et al. Hyperinsulinemia: a link between hypertension, obesity and glucose intolerance. J Clin Invest. 75:1985;809-817.
2. Ferrannini E, Buzzigoli G, Bonadonna M, et al. Insulin resistance in essential hypertension. N Engl J Med. 317:1987;350-357.
3. Mondon CE, Reaven GM. Evidence for abnormalities of insulin metabolism in rats with spontaneous hypertension. Metabolism. 37:1988;303-305.
4. Reaven GM, Twersky J, Chang H. Abnormalities of carbohydrate and lipid metabolism in Dahl rats. Hypertension. 18:1991;630-635.
5. Kotchen TA, Zhang HY, Covelli M, Blehschmidt N. Insulin resistance and blood pressure in Dahl rats and in one-kidney-one-clip hypertensive rats. Am J Physiol. 261:1991;E692-E697.
6. Dall'Aglio E, Rosini P, Ferrari P. Abnormalities of insulin and lipids in insulin resistant rats. Am J Hypertens. 4:1991;773-775.
7. Bursztyn M, Gutman A, Ben-Ishay D. Insulin resistance in spontaneously hypertensive rats but not in deoxycorticosterone-salt or renal vascular hypertension. J Hypertens. 10:1992;137-142.
8. Rao HR. Insulin resistance in spontaneously hypertensive rats: difference in interpretation based on insulin and glucose clamp studies. Diabetes. 42:1993;1364-1371.
9. Julius S, Gudbransson T, Jamerson K, et al. The hemodynamic link between insulin resistance and hypertension. J Hypertens. 9:1991;983-996.
10. Baron AD, Brechtel-Hook G, Johnson A, Hardin D. Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure. Hypertension. 21:1993;129-135.
11. Steinberg HO, Brechtel G, Johnson A, et al. Insulin mediated skeletal muscle vasodilatation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest. 94:1994;1172-1179.
12. Scherrer U, Randin D, Vollenweider L, Pascal N. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 94:1994;2511-2515.
13. Baron AD, Steinberg HO, Chaker H, et al. Insulin-mediated skeletal muscle vasodilatation contributes to both insulin sensitivity and responsiveness in lean humans. J Clin Invest. 96:1995;786-792.
14. Bursztyn M, Raz I, Mekler J, Ben-Ishay D. Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. Hypertension. 23:((part 2)):1994;1051-1053.
15. Buchanan TA, Sipos GF, Gadalah S, et al. Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension. 18:1991;341-347.
16. Frontoni S, Ohman L, Haywood JR, Rossetti L. Increased insulin sensitivity in the high sodium one-kidney-one-figure-8 hypertensive rat. Hypertension. 20:1992;192-198.
17. Baron AD, Brechtel G, Johnson A, et al. Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity. Studies in lean and obese men. J Clin Invest. 93:1994;2453-2462.
18. Townsend RR, Dipette DJ. Pressor doses of angiotensin II increase insulin mediated glucose uptake in normotensive men. Am J Physiol. 265:1993;E362-E366.
19. Buchanan TA, Thawani H, Kades W, et al. Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism. J Clin Invest. 92:1993;760-762.
20. Morris AD, Petrie JR, Ueda S, et al. Pressor and subpressor doses of angiotensin II increase insulin sensitivity in NIDDM. Dissociation of metabolic and blood pressure effects. Diabetes. 43:1994;1445-1449.
21. Davidsson RL, Johnson AK, Lewis SJ. Nitrosyl factors mediate active neurogenic hindquarters vasodilation in the conscious rat. Hypertension. 23:((part 2)):1994;962-968.
22. Gardiner SM, Compten AM, Bennett T, et al. Control of regional blood flow by endothelium derived nitric oxide. Hypertension. 15:1990;486-492.
23. 14C]-deoxyglucose method for measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem. 28:1977;897-916.
24. 3H]-deoxyglucose method for comparing rates of glucose utilization and muscular responses among rat tissues in vivo: validation of the model and absence of an insulin effect in the brain. Diabetes. 33:1984;141-151.
25. Bursztyn M, Mekler J. Acute hypertensive response to vanadate, an insulinomimetic agent. J Hypertens. 11:1993;605-609.
26. Swislocki A, Eason T, Kaysen GA. Oral administration of the nitric biosynthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME), causes hypertension but not glucose intolerance or insulin resistance. Am J Hypertens. 8:1995;1009-1014.
27. Baron AD, Zhu JS, Marshal S, et al. Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor, L-NMMA, in rats. Am J Physiol. 269:1995;E709-E715.
28. Natali A, Bonadonna R, Santoro D, et al. Insulin resistance and vasodilation in essential hypertension. Studies with adenosine. J Clin Invest. 94:1994;1570-1576.
29. Shamis A, Carrol J, Rosenthal T. Insulin resistance in secondary hypertension. Am J Hypertens. 5:1992;28-30.