The role of chemotherapy in head and neck cancer

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 20, Issue 5, 1997, Pages 449-461

  Hughes, Randall S ^a   Frenkel, Eugene P ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Chemoradiation; Chemotherapy; Head and neck cancer

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; EDATREXATE; FLUOROURACIL; FOLINIC ACID; HYDROXYUREA; IFOSFAMIDE; METHOTREXATE; MITOMYCIN C; PACLITAXEL; TRIMETREXATE; VINCRISTINE;

ARTICLE; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; DRUG EFFICACY; HEAD AND NECK CANCER; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG TOXICITY; METASTASIS; MUCOSA INFLAMMATION; NEPHROTOXICITY; NEUROTOXICITY; ORAL DRUG ADMINISTRATION; RECURRENT CANCER; TREATMENT INDICATION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PALLIATIVE CARE; RADIOTHERAPY; REMISSION INDUCTION; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0030842907     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199710000-00004     Document Type: Article

References (130)

1. Al-Sarraf M, Kish J, Ensley J. The Wayne State University experience with adjuvant chemotherapy of head and neck cancer. Hematol-Oncol Clin North Am 1991;5:687-701.
2. Dimery IW, Hong \VK. Overview of combined modality therapies for head and neck cancer. J Natl Cancer Inst 1993; 85:95-110.
3. Clark JR, Frei E. Chemotherapy for head and neck cancer: progress and controversy in the management of patients with MO disease. Semin Oncol 1989;16(suppl 6):44-57.
4. Dimery IW. Chemotherapy in head and neck cancer. In: Meyerhoff WL, Rice DH, eds. Otolaryngology: head and neck surgery. Philadelphia: WB Saunders, 1992:1027-45.
5. Yokes EE. Head and neck cancer. In: Perry MC, ed. Chemotherapy source book. Baltimore: Williams & Wilkins, 1992: 918-31.
6. Al-Sarraf M. Head and neck cancer: chemotherapy concepts. Semin Oncol 1988; 15:70-85.
7. Drelichman A, Cummings G, Al-Sarraf M, et al. A randomized trial of combination cisplatin, oncovin, and bleomycin versus methotrexate in patients with advanced squamous cell carcinoma of the head and neck.' Cancer 1983;52:399-403.
8. DeConti RC, Schoenfeld D. A randomized prospective comparison of intermittent methotrexate, methotrexate with leucovorin and a methotrexate combination in head and neck cancer. Cancer 1981;48:1061-70.
9. Vogle WR, Jacobs J, Moffitt S, et al. Methotrexate therapy with or without citrovorum factor in carcinoma of the head and neck, breast, and colon. Cancer Clin Trials 1979;2:22736.
10. Taylor SG IV, McGuire WP, Hauck \VW, et al. A randomized comparison of high-dose infusion metholrexate versus standard-dose weekly therapy in head and neck squamous cancer. J Clin Oncol 1984;2:1006-11.
11. Woods RL, Fox RM, Tattersall MHN. Methotrexate treatment of advanced head and neck cancers: a dose-response evaluation. Cancer Treat Rep 1981; 65:155-9.
12. Al-Sarraf M. Chemotherapeutic management of head and neck cancer. Cancer Melast Rev 1987;6:191-8.
13. Haas CD, Coltman CA, Gottlieb JA, et al. Phase II evaluation of bleomycin. Cancer 1976;38:8-12.
14. Wittes R, Heller K, Randolph V, et al. Cis-dichlorodiammine platinum based chemotherapy as initial treatment of advanced head and neck cancer. Cancer Treat Rep 1977;61:359-66.
15. Guthrie TH, Brubaker LHJ, Porubsky ES, et al. Circadian cisplatin, bleomycin, and 5-fiuorouracil in advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 1990; 9:175.
16. Harlin KA, Kühn JG, Myers JW, et al. High-dose cisplatin for locally advanced metastatic head and neck cancer: a phase II pilot study. Cancer 1989; 63:423-4.
17. Forastiere AA, Takasugi BJ, Baker SR, et ai. High-dose cisplatin in advanced head and neck cancer. Cancer Cliemother Pharmacol 1987; 19:155-8.
18. Veronesi A, Zagonel V, Pirelli V, et al. High-dose versus lowdose cisplatin in advanced head and neck squamous carcinoma: a randomized study. J Clin Oncol 1985;3:1105-8.
19. Al-Sarraf M. Clinical trials with fluorinated pyrimidines in patients with head and neck cancer. Invest New Drugs 1981:7:71-81.
20. Tapazoglon E, Kish J, Ensley J, et al. The activity of single agent 5-fluorouracil infusion in advanced and recurrent head and neck cancer. Cancer 1986; 57:1105-9.
21. Schantz SP, Harrison LB, Hong WK. Cancer of the head and neck. In: Devita VT, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology. (4th ed.) Philadelphia; Lippincott, 1993:574-672.
22. Kish J, Ansley J, Al-Sarraf M, et al. Activity of CHIP and CBDCA (platinum analogs) in recurrent epidermoid cancer of the head and neck. Proc Am Soc Clin Oncol 1985;4:130.
23. Green MD, Sherman P, Zaleberg J. Phase II study of 10-EdAM in patients with squamous cell carcinoma of the head and neck. Invest New Drugs 1992; 10:31-4.
24. Robert F. Trimetrexate as a single agent in patients with advanced head and neck cancer. Seinin Oncol 1988; 15:22-6.
25. Cervellino JC, Aranjo CE, Pirisi C, et al. Ifosfamide and mesna for the treatment of advanced squamous cell head and neck cancer: a Getlac study. Oncology 1991;48:89-92.
26. Forastiere AA. Use of paclitaxel (Taxol) in squamous cell carcinoma of the head and neck. Semin Oncol 1993;20(suppl 3):56-60.
27. Price LA, Hill BT. A kinetically-based logical approach to the chemotherapy of head and neck cancer. Clin Otolaryngol 1977;2:339-45.
28. Price LA, Hill BT, Calvert AH, et al. Improved results in combination chemotherapy of head and neck cancer using a kinetically-based approach: a randomized study with and without adriamycin. Oncology 1978;35:26-9.
29. Holoye PY, Byers RM, Gard DA, et al. Combination chemotherapy of head and neck cancer. Cancer 1978;42:1661-9.
30. Creagan ET, Fleming TR, Edmonson JH, et al. Cyclophosphamide, adriamycin, and cis-diamminedichloro-platinum (II) in the treatment of patients with advanced head and neck cancer. Cancer 1981;47:240-4.
31. Wittes RE, Brescia F, Young CW, et al. Combination chemotherapy with cis-diamminedichloroplatinum (II) and bleomycin in tumors of the head and neck. Oncology 1975; 32:202-7.
32. Amer MH, Izbick RM, Vaitkevicius VK, et al. Combination chemotherapy with cis-diamminedichloroplatinum, oncovin, and bleomycin (COB) in advanced head and neck cancer. Cancer 1980;45:217-23.
33. Amrein PC, Fingert H, Weitzman SA. Cisplatin-vincristinebleomycin therapy in squamous carcinoma of the head and neck. J Clin Oncol 1983; 1:421-7.
34. Caradonna R, Paladine W, Ruckdeschel JC, et al. Methotrexate, bleomycin, and high-dose cis-dichlorodiammine platinum (II) in the treatment of advanced epidermoid carcinoma of the head and neck. Cancer Treat Rep 1979;63:489-91.
35. Ervin TJ, Weichselbaum R, Miller D, et al. Treatment of advanced squamous cell carcinoma of the head and neck with cisplatin, bleomycin, and methotrexate (PBM). Cancer Treat Rep 1981:65:787-91.
36. Vogl SE, Kaplan BH. Chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum (II) in an effective out-patient schedule. Cancer 1979:44:26-31.
37. Brown AW, Blom J, Butler WM, et al. Combination chemotherapy with vinblastine, bleomycin, and cis-diamminedichloroplatinum (II) in squamous cell carcinoma of the head and neck. Cancer 1980:45:2830-5.
38. Williams SD, Velez-Garcia E, Essessee I, et al. Chemotherapy for head and neck cancer. Comparison of cisplatin and vinblas-tine and bleomycin versus mcthotrexale. Cancer 1986;57:1823.
39. Kish JA, Weaver A, Jacobs J, et al. Cisplatin and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer. Cancer 1984;53:1819-24.
40. Kish JA, Ensley JF, Jacob J, et al. A randomized trial of cisplatin (CACP) and 5-fluorouracil (5-FU) infusion and CACP + 5-FU bolus for recurrent and advanced squamous cell carcinoma of the head and neck. Cancer 1985;56:2740-44.
41. Jacobs C, Lyman G, Velez-Garcia E, et al. A phase III randomized study comparing cisplatin and fluorouracil as single agents and in combination for advanced squamous cell carcinoma of the head and neck. J Clin Oncol 1992; 10:257-63.
42. Forastiere AA, Metch B, Schuller DE, et al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous cell carcinoma in the head and neck: a Southwest Oncology Group study. J Clin Oncol 1992; 10:1245-51.
43. Amrein PC, Weitzman SA. Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5-fluorouracil. J Clin Oncol 1985;3:1632-9.
44. Merlano M, Tatarek R, Grunaldi A, et al. Phase I-II trial with cisplatin and 5-FU in recurrent head and neck cancer: an effective out-patient schedule. Cancer Treat Rep 1985;69: 961-4.
45. Raymond MG, Lyman GH. Treatment of unresectable/recurrent epidermoid carcinoma of the head and neck with cisplatin plus 5-fluorouracil infusion. Proc Am Soc Clin Oncol 1985; 4:133.
46. Fosser VP, Paccagnella E, Venturelli A, et al. Cisplatin (CDDP) + 5-fluorouracil (5-FU) 120 hour infusion in patients with recurrent and disseminated head and neck cancer. Proc Am Soc Clin Oncol 1985;4:150.
47. Yokes EE, Choi KE, Schilsky RL, et al. Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer. J Clin Oncol 1988;6:618-26.
48. Amrein PC. Cisplatin and 5-fluorouracil vs. the same plus bleomycin and methotrexate in recurrent squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 1990;9:175.
49. Dasmahapatra KS, Yee R, Hill GH, et al. 5-FU and cisplatin in advanced squamous cell head and neck cancer. Proc Am Soc Clin Oncol 1985;4:132.
50. Hamm JI, Joseph G, Blumenreich MS, et al. Phase II trial of high-dose cisplatin, 5-fluorouracil, bleomycin, and methotrexate in advanced/recurrent head and neck cancer. Proc Am Soc Clin Oncol 1990;9:175.
51. Forastiere AA. Randomized trials of induction chemotherapy, a critical review. Hematol-Oncol Clin North Am 1991;5:72536.
52. Ensley J, Maciorowski Z, Pietraszkiewicz H, et al. Prospective comparison of cytotoxic response and DNA content parameters in advanced squamous cell cancer of the head and neck. Proc Am Soc Clin Oncol 1990;9:173.
53. Tarpley JL, Chrétien PB, Alexander JC, et al. High-dose methotrexate as a preoperative adjuvant in the treatment of epidermoid carcinoma of the head and neck, a feasibility study and clinical trial. Am J Surg 1975; 130:481-6.
54. Ervin TJ, Kirkwood J, Weichselbaum RR, et al. Improved survival for patients with advanced carcinoma of the head and neck treated with methotrexate-leucovorin prior to definitive radiotherapy or surgery. Laryngoscope 1981;91:1181-90.
55. Condit PT. Treatment of carcinoma with radiation therapy and methotrexate. Mo Med 1968:65:832-5.
56. Fazekas JT, Sommer C, Kramer S. Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic, larynx or hypopharynx.J Radiât Oncol Biol Pliys 1980;6: 533-41.
57. Taylor SG IV, Appelbaum E, Shavel JL, et al. A randomized trial of adjuvant chemotherapy in head and neck cancer. J Clin Oncol 1985; 3:672.
58. Jacobs C, Bertino JR, Goffinet DR, et al. 24-hour infusion of cisplatin in head and neck cancers. Cancer 1978;42:2I35-40.
59. Schaefer SD, Middleton R, Reisch J, et al. Cisplatinum induction chemotherapy in the multi-modality initial treatment in advanced stage IV carcinoma of the head and neck. Cancer 1983:51:2168-74.
60. Popkin JD, Hong WK, Bromer RH, et al. Induction bleomycin infusion in head and neck cancer. Am J Clin Oncol 1984; 7:199-204.
61. Pennacchio JL, Hong WK, Shapshay S, et al. Combination of cisplatinum and bleomycin prior to surgery and/or radiotherapy compared with radiotherapy alone for the treatment of advanced squamous cell carcinoma of the head and neck. Cancer I982;50:2795-801.
62. Click JH, Marcial V, Richter M, et al. The adjuvant treatment of inoperable stage III and IV epidermoid carcinoma of the head and neck with platinum and bleomycin infusions prior to definitive radiotherapy: an RTOG pilot study. Cancer 1980; 46:1919-24.
63. Randolph VL, Vallejo A, Spiro RH, et al. Combination therapy of advanced head and neck cancer. Induction of remissions with diamminedichloroplatinum (II) bleomycin, and radiation. Cancer 1978;41:460-7.
64. Haines I, Bosl G, Pfister D, et al. Very high-dose cisplatin with bleomycin infusion as initial treatment of advanced head and neck cancer. J Clin Oncol 1987:5:1594-600.
65. Stell PM, Dalby JE, Strickland P, et al. Sequential chemotherapy and radiotherapy in advanced head and neck cancer, din Radial 1980; 34:463-7.
66. Head and Neck Contracts Program. Adjuvant chemotherapy for advanced head and neck squamous carcinoma: final report of the Head and Neck Contracts Program. Cancer 1987; 60:301-11.
67. Kun LE, Toohill RJ, Holoye PY, et al. A randomized study of adjuvant chemotherapy for cancer of the upper aerodigestive tract. Int J Radial Oncol Biol Phys 1986; 12:173-8.
68. Schuller DE, Metch B, Stein DW, et al. Preoperative chemotherapy in advanced resectable head and neck cancer: final report of the Southwest Oncology Group. Laryngoscope I988;98:1205-ll.
69. Clark JR, Fallon BG, Dreyfuss AI, et al. Chemotherapeutic strategies in the multidisciplinary treatment of head and neck cancer. Semin Oncol 1988;15(suppl 3):35-44.
70. Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991:324:1685-90.
71. Toohill RJ, Anderson T, Byhardt RW, et al. Cisplatin and fluorouracil as neoadjuvant therapy in head and neck cancer. Arch Otolaryngol Head Neck Sitrg 1987; 113:758-61.
72. Paccagnella A, Caramiglia G, Zorat PL, et al. Chemotherapy (CT) before locoregional treatment in stage III + IV head and neck cancer: intermediate results of an ongoing randomized phase III trial: a GTSIC study. Proc Am Soc Clin Oncol 1990;9:173.
73. Martin M, Hazan A, Vergnes L, et al. Randomized study of 5-fluorouracil (5-FU) and cisplatinum (DDP) as neoadjuvant therapy in head and neck cancer. Proc Am Soc Clin Oncol 1989;8:175.
74. Haas C, Byhardt R, Cox J, et al. Randomized study of 5-fiuorouracil and cisplatinum as initial therapy of locally advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol 1985;4:143.
75. Vokes EE, Schilsky RL, Weichselbaum RR, et al. Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for locally advanced head and neck cancer: a clinical . and pharmacologie analysis. J Clin Oncol 1990:8:241-7.
76. Dreyfuss AI, Clark JR, Wright JE, et al. Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Intern Med 1990; 112:167-72.
77. Greenberg B, Ahmann F, Garewal H, et al. Neoadjuvant ther-apy for advanced head and neck cancer with allopurinol-modulated high-dose 5-fluorouracil with cisplatin: a phase I-II study. Cancer 1987;59:1860-5.
78. Johnson JT, Meyer EN, Srodes CH, et al. Maintenance chemotherapy for high risk patients. A preliminary report. Arch Ololaryngol 1985;III:727-9.
79. Johnson JJ, Meyers EN, Schramm VL, et al. Adjuvant chemotherapy for high risk squamous cell carcinomas of the head and neck. J din Oncol 1987;5:456-8.
80. Domenge C, Marandas P, Vignoud J, et al. Post-surgical adjuvant chemotherapy in extracapsular spread invaded lymph node (N+R+) of epidermoid carcinoma of the head and neck: a randomized multicentric trial. Proc. 2nd international conference on head and neck cancer: combined therapy. Boston, July 31-August 5, 1988.
81. Laramore G, Scott CB, Al-Sarraf M, et al. Ajuvant chemotherapy for resectable head and neck cancer: report on Intergroup study 0034. /;;/ J Radiât Oncol Biol Phys 1992:23:705-13.
82. Ervin TJ, Clark JR, Weichselbaum RR, et al. An analysis of induction and adjuvant chemotherapy in the multidisciplinary treatment of squamous cell carcinoma of the head and neck. J Clin Oncol 1987;5:10-20.
83. Jacobs C, Makuch R. Efficacy of adjuvant chemotherapy for patients with resectable head and neck cancer: a subset analysis of the Head and Neck Contracts Program. J Clin Oncol 1990;8:838-47.
84. Fu KK, Phillips TL. Biologic rationale of combined radiotherapy and chemotherapy. Hematol . Oncol. Clin North Am 1991;5:4:737-51.
85. Yokes EE, Weichselbaum RR. Chemoradiotherapy for head and neck cancer. Principles and practice of oncology updates 1993;7:1-13.
86. Yokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Oncol 1990;8:911-34.
87. Gupta NK, Pointon RCS, Wilkinson PM. A randomized clinical trial to contrast radiotherapy with radiotherapy and methotrexate given synchronously in head and neck cancer. Clin Radial 1987;38:575-81.
88. Shanta Y, Krishnamurthi S. Combined bleomycin and radiotherapy in oral cancer, din Radial 1980; 31:617-20.
89. Fu KK, Phillips TL, Silverberg IJ, et al. Combined radiotherapy and chemotherapy with bleomycin and methotrexate for advanced inoperable head and neck cancer: an update of a North California Oncology Group randomized trial. J Clin Oncol 1987;5:1410-8.
90. Kapstad B. Cobalt and bleomycin against carcinomas of the head and neck. Ada Otolaryngol 1979;(suppl. 360):171-3.
91. Parvinen LM, Parvinen M, Nordman E, et al. Combined bleomycin and radiation therapy in squamous cell carcinoma of the head and neck region. Acta Radial Oncol 1985;24:487-9.
92. Cachin Y, Jortay A, Sancho H, et al. Preliminary results of a randomized E.O.R.T.C. study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx. Eur J Cancer 1977; 13:1389-95.
93. Gollin FF, Johnson RO. Pre-irradiation 5-fluorouracil infusion in advanced head and neck carcinomas. Cancer 1971;27:768-70.
94. Lo TCM, Wiley AL, Ansfisld FJ, et al. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. AJR 1976; 126:229-35.
95. Shigematsu Y, Sakai S, Fuchihata H. Recent trials in the treatment of maxillary sinus carcinoma with special reference to the chemical potentiation of radiation therapy. Acta Orolaryngol 197I;71:63-70.
96. Slotman GJ, Doolittle CH, Glicksman AS. Preoperative combined chemotherapy and radiation therapy plus radical surgery in advanced head and neck cancer. Cancer 1992;69:2736-43.
97. Haselow RE, Adams GS, Oken MM. Cisplatinum (DDP) and radiation therapy (RT) for locally advanced unresectable head and neck cancer. P roc Am Soc Clin Oncol 1983;2:160.
98. Al-Sarraf M, Pajak TF, Marcial VA, et al. Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck: an RTOG study. Cancer 1987;59:259-65.
99. Haselow RE, Warshaw MG, Oken MM. Radiation alone versus radiation with weekly low dose cisplatin in unresectable cancer of the head and neck. In: Fee WE Jr, Goepfert H, Johns ME, et al. eds. Head and neck cancer; vol 2. Philadelphia; BC Decker, 1990:279-81.
100. Al-Sarraf M, Tapazoglon F, Ensley JF, et al. Significant locoregional control of advanced head and neck cancer (HN-CA) with concurrent cisplatin and radiotherapy (RT) after initial response to induction chemotherapy (CT). Proc Am Soc Clin Oncol 1990; 9:173.
101. Ensley JF, Ahmad K, Kish JA, et al. Improved response to radiation and concurrent cisplatin (CACP) in patients with advanced head and neck cancers (SCCHN) that fail induction therapy. Proc Am Soc Clin Oncol 1989;8:168.
102. Schnabel T, Zamboglou N, Pape H, et al. Phase II trial with carboplatin and simultaneous radiation in previously untreated advanced squamous cell carcinoma of the head and neck (SCCHN). Proc Am Soc Clin Oncol I990;9:176.
103. Jacobs MC, Eisenberger M, Oh MC, et al. Carboplatin and radiotherapy for stage IV carcinoma of the head and neck: a phase I-II study, lut J Radiât Oncol Biol Phys 1989; 17:3613.
104. Weissberg JB, Son YH, Papac RJ, et al. Randomized clinical trial of mitomycin C as an adjunct to radiotherapy in head and neck cancer, lut J Radiât Oncol Biol Phys 1989; 17:3-9.
105. Stefani S, Chung TS. Hydroxyurea and radiotherapy in head and neck cancer-long term results of a double-blind randomized prospective study. lut J Radiât Oncol Biol Phys 1980; 6:1398.
106. Richards GJ, Chambers RG. Hydroxyurea: a radiosensitizer in the treatment of neoplasms of the head and neck. Am J Roentgenol Radium Nucl Med 1969;55:555-65.
107. Richards GJ, Chambers RG. Hydroxyurea in the treatment of neoplasms of the head and neck. Am J Surg 1973; 126:513-8.
108. Taylor SG IV, Murthy AK, Showel JL, et al. Improved control in advanced head and neck cancer with simultaneous radiation and cisplatin/5-FU chemotherapy. Cancer Treat Rep 1985; 69:933-9.
109. Adelstein DJ, Sharan VM, Earle AS, et al. Long term results after chemoradiotherapy for locally confined squamous cell head and neck cancer. Am J Clin Oncol 1990; 13:440-7.
110. Adelstein DJ, Kalish LA, Adams GL, et al. Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: an Eastern Cooperative Oncology Group pilot study. J Clin Oncol 1993; 11:2136-42.
111. Tomio L, Zorat PL, Paccagnella A, et al. A pilot study of concomitant radiation and chemotherapy in patients with locally advanced head and neck cancer. Am J Clin Oncol 1993; 16:264-7.
112. Stryker JA, Harvey HA, Houch JR, et al. Advanced head and neck cancer: low-dose, split-course radiation therapy and simultaneous infusion of 5-fluorouracil and cisplatin. Radiology 1990; 176:567-71.
113. Merlano M, Vitale V, Rosso.R, et al. Treatment of advanced squamous cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med 1992;327: 1115-21.
114. Weissler MC, Melin S, Sailer SL, et al. Simultaneous chemoradiation in the treatment of advanced head and neck cancer. Arch Otolaryngol Head Neck Surg 1992; 118:806-10.
115. Yokes EE, Panje WR, Schilsky RL, et al. Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II pilot study. J Clin Oncol 1989;7:761-8.
116. Gandia D, Wibault P, Guillot T, et al. Simultaneous chemoradiotherapy as salvage treatment in locoregional recurrences of squamous head and neck cancer. Head & Neck 1993; 15:8-15.
117. Weppelmann B, Wheeler RH, Peters GH, et al. Treatment of recurrent head and neck cancer with 5-fluorouracil, hydroxyurea and re-irradiation. Int J Radiât Oncol Biol Pliys 1992; 22:1051-6.
118. Wallner JE, Li GC. Effect of cisplatin resistance on cellular radiation response. lut J Radiât Oncol Biol Pliys 1987; 13:58791.
119. Merlano M, Rosso R, Sertoli MR, et al. Sequential versus alternating chemotherapy and radiotherapy in stage III-IV squamous cell carcinoma of the head and neck: a phase III study. J Clin Oncol 1988;6:627-32.
120. Merlano M, Bargarino G, Benasso M, et al. Combined chemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck. Cancer 1991;67:915-21.
121. Adelstein DJ, Sharan VM, Earle AS, et al. Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer. Cancer 1990;65:1685-9.
122. Yokes EE, Haraf DJ, Weichselbaum RR, et al. Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. Semin Oncol 1992;19(suppl ll):47-56.
123. Ensley JF, Jacobs JR, Weaver A, et al. The correlation between response to cisplatin combination chemotherapy and subsequent radiotherapy in previously untreated patients with advanced squamous cell cancers of the head and neck. Cancer 1984:54:811-4.
124. Ervin TJ, Weichselbaum RR, Miller D, et al. The role of chemotherapy for advanced carcinoma of the supraglottic and glottic larynx. Otolaryngol Clin North Am 1984; 17:209-14.
125. Popkin J, Hong WK, Dorman B, et al. Voice preservation with sequential chemotherapy and radiation therapy without laryngectomy in patients with operable stage II, IV squamous cell carcinoma of the larynx and hypopharynx. Proc Am Soc Clin Oncol 1985;4:149.
126. Jacob C, Goffinet DR, Goffinet L, et al. Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer. A report from the Northern California Oncology Group. Cancer 1987:60:1178-83.
127. Adelstein DJ, Sharan VM, Damm C, et al. Concurrent radiation therapy, 5-fluorouracil, and cisplatin for stage II, III and IV node-negative squamous cell head and neck cancer. Cancer 1992:70:2685-90.
128. Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991:324:1685-90.
129. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med 1992;328:184-94.
130. Merlano M, Benasso M, Corvo R, et al. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy . compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer lust 1996;88:583-9.