Importance of estrogen receptors in hepatic LDL receptor regulation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 9, 1997, Pages 1800-1805

  Parini, Paolo ^b   Angelin, Bo ^b   Rudling, Mats ^a  

^a Novum   (Sweden)

^b NONE

Author keywords

Estrogen receptor; Fasting; Growth hormone; LDL receptor; mRNA

Indexed keywords

ANTIESTROGEN; CLOMIFENE; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; TAMOXIFEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ESTROGEN ACTIVITY; FOOD INTAKE; HORMONE RECEPTOR INTERACTION; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RNA ANALYSIS;

EID: 0030842598     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.9.1800     Document Type: Article

References (18)

1. Boyd GS, McGuire WD. The effect of hexoestrol on cholesterol metabolism in the rat. Biochem J. 1956;62:19P.
2. Steinberg M, Tolksdorf S, Gordon AS. Relation of the adrenal and pituitary to the hypocholesterolemic effect of estrogen. Endocrinology. 1967;81:340-344.
3. 125I-labelled serum low density lipoprotein in normal and estrogen-treated male rats. Biochem Biophys Res Commun. 1971;44:1471-1477.
4. Kovanen PT, Brown MS, Goldstein JL. Increased binding of low density lipoprotein to liver membranes from rats treated with 17 α-ethinyl estradiol. J Biol Chem. 1979;254:11367-11373.
5. Windler EE, Kovanen PT, Chao YS, Brown MS, Havel RJ, Goldstein JL. The estradiol-stimulated lipoprotein receptor of rat liver: a binding site that mediates the uptake of rat lipoproteins containing apoproteins B and E. J Biol Chem. 1980;255:10464-10471.
6. Ma PT, Yamamoto T, Goldstein JL, Brown MS. Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 α-ethinyl estradiol. Proc Natl Acad Sci U S A. 1986;83:792-796.
7. Chao YS, Windler EE, Chen GC, Havel RJ. Hepatic catabolism of rat and human lipoproteins in rats treated with 17 α-ethinyl estradiol. J Biol Chem. 1979;254:11360-11366.
8. Ferreri LF, Naito HK. Effect of estrogens on rat serum cholesterol concentration: consideration of dose, type of estrogen, and treatment duration. Endocrinology. 1978;102:1621-1627.
9. Semenkovich CF, Ostlund RE Jr. Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line Hep G2. Biochemistry. 1987;26:4987-4992.
10. Wade DP, Knight BL, Soutar AK. Hormonal regulation of low-density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells: insulin increases LDL receptor activity and diminishes its suppression by exogenous cholesterol. Eur J Biochem. 1988;174:213-218.
11. Brindley DN, Salter AM. Hormonal regulation of the hepatic low density lipoprotein receptor and the catabolism of low density lipoproteins: relationship with the secretion of very low density lipoproteins. Prog Lipid Res. 1991;30:349-360.
12. Rudling M, Norstedt G, Olivecrona H, Reihnér E, Gustafsson J-Å, Angelin B. Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc Natl Acad Sci U S A. 1992;89:6983-6987.
13. Rudling M, Angelin B. Stimulation of rat hepatic low density lipoprotein receptors by glucagon: evidence of a novel regulatory mechanism in vivo. J Clin Invest. 1993;91:2796-2805.
14. Angelin B. Studies on the regulation of hepatic cholesterol metabolism in humans. Eur J Clin Invest. 1995;25:215-224.
15. Henriksson P, Stamberger M, Eriksson M, et al. Oestrogen-induced changes in lipoprotein metabolism: role in prevention of atherosclerosis in the cholesterol-fed rabbit. Eur J Clin Invest. 1989;19:395-403.
16. Angelin B, Olivecrona H, Reihnér E, et al. Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology. 1992;103:1657-1663.
17. Rudling MJ. Role of the liver for the receptor-mediated catabolism of low-density lipoprotein in the 17 α-ethinylestradiol-treated rat. Biochim Biophys Acta. 1987;919:175-180.
18. Parini P, Angelin B, Lobie PE, Norstedt G, Rudling M. Growth hormone specifically stimulates the expression of low density lipoprotein receptors in human hepatoma cells. Endocrinology. 1995;136:3767-3773.