Induction of mitochondrial dysfunction and apoptosis in HeLa cells by bis-pyridinium oximes, a newly synthesized family of lipophilic biscations

Biochemical Pharmacology

Volumn 53, Issue 10, 1997, Pages 1543-1552

  Nocentini, Silvano ^a,c   Moreno, Giuliana ^b   Petit, Patrice X ^c   Guggiari, Michèk ^a   Salet, Christian ^b   Demerseman, Pierre ^c   Dodin, Guy ^d  

^a INSTITUT CURIE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c CNRS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Apoptosis; Bis pyridinium oximes; Cell cycle; HeLa cells; Mitochondrial DNA content; Mitochondrial function

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIS(PYRIDINIUM OXIME) DERIVATIVE; MITOCHONDRIAL DNA;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DRUG SYNTHESIS; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; LIPOPHILICITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; BENZIMIDAZOLES; CARBOCYANINES; CELL CYCLE; CELL DIVISION; DNA, MITOCHONDRIAL; FLUORESCENT DYES; HELA CELLS; HUMANS; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; OXIMES; OXYGEN CONSUMPTION; PYRIDINIUM COMPOUNDS; RADIATION-SENSITIZING AGENTS;

EID: 0030842119     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00092-0     Document Type: Article

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