Effect of praziquantel and oxamniquine treatment on human isotype responses to Schistosoma mansoni: Elevated IgE to adult worm

Parasite Immunology

Volumn 19, Issue 7, 1997, Pages 333-335

  Webster, M ^a   Fallon, P G ^a   Fulford, A J C ^a   Butterworth, A E ^a   Ouma, J H ^b   Kimani, G ^c   Dunne, D W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MINISTRY OF HEALTH   (Kenya)

^c KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

Author keywords

IgE; Oxamniquine; Praziquantel; Schistosomiasis

Indexed keywords

IMMUNOGLOBULIN E; OXAMNIQUINE; PARASITE ANTIGEN; PRAZIQUANTEL;

ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; KENYA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; WORM EGG; WORM TEGUMENT;

SCHISTOSOMA MANSONI;

EID: 0030842102     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-211.x     Document Type: Article

References (7)

1. Butterworth A.E., Capron M., Cordingley J.S. et al. (1985) Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune responses. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 393-408
2. Davis A. (1993) In Human Schistosomiasis, eds. J. Jordan, G. Webbe & R.F. Sturrock, pp. 367-404. CAB International, Wallingford, UK
3. Dunne D.W., Butterworth A.E., Fulford A.J.C. et al. (1992) Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection. European Journal of Immunologv 22, 1483-1494
4. Fallon P.G., Fookes R.E. & Wharton G. (1996) Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult S. mansoni: Implications for drug-antibody synergy. Parasitology 112, 47-58
5. Hagan P., Blumenthal U.R., Dunn D. et al. (1991) Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 349, 243-245
6. Rihet P., Demeure C.E., Bourgois A. et al. (1991) Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels. European Journal of Immunology 21, 2679-2686
7. Webster M., Fallon P.G., Fulford A.J.C. et al. (1997) IgG4 and IgE responses to Schistosoma mansoni adult worm after treatment. Journal of Infectious Diseases 175, 493-494