Central administration of morphine inhibits brain and liver ornithine decarboxylase activity in neonatal rats: Involvement of transcription- and non-transcription-dependent mechanisms

European Journal of Pharmacology

Volumn 331, Issue 2-3, 1997, Pages 145-153

  Bartolome, Jorge V ^a   Alicke, Bruno ^a   Bartolome, Maria B ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endorphin; Development; Growth; Insulin; Intracerebroventricular; Omithine decarboxylase mRNA; Opiate

Indexed keywords

BETA ENDORPHIN; INSULIN ZINC SUSPENSION; MESSENGER RNA; MORPHINE; NALOXONE; ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FEMALE; GROWTH CURVE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LIVER; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANALGESICS, OPIOID; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAVENTRICULAR; INSULIN; LIVER; MORPHINE; ORNITHINE DECARBOXYLASE; POLY A; RATS; RATS, SPRAGUE-DAWLEY; RNA; TRANSCRIPTION, GENETIC;

EID: 0030841942     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01045-5     Document Type: Article

References (46)

1. Bartolome, J.V., Bartolome, M.B., Daltner, L.A., Evans, C.J., Barchas, J.D., Kuhn, C.M., Schanberg, S.M., 1986. Effects of β-endorphin on ornithine decarboxylase in tissues of developing rats: A potential role for this endogenous neuropeptide in the modulation of tissue growth. Life Sci. 38, 2355.
2. Bartolome, J.V., Bartolome, M.B., Harris, E.B., Schanberg, S.M., 1987. Nα-acetyl-β-endorphin stimulates ornithine decarboxylase activity in preweanling rat pups: Opioid and non-opioid-mediated mechanisms. J. Pharmacol. Exp. Ther. 240, 895.
3. Bartolome, J.V., Bartolome, M.B., Lorber, B.A., Schanberg, S.M., 1991. CNS β-endorphin regulation of insulin-induced ornithine decarboxylase expression in liver of neonatal rats. Mol. Cell. Neurosci. 2, 1.
4. Bartolome, J.V., Chang, K.-J., Bartolome, M.B., 1995a. The inhibition of ornithine decarboxylase activity in developing rat tissues by central nervous system β-endorphin is mediated by μ-opioid receptors, but not by δ- or -opioid receptors. Eur. J. Pharmacol. 284, 43.
5. Bartolome, J.V., Wang, S., Bartolome, M.B., 1995b. Transcription-dependent and -independent regulation of hepatic ornithine decarboxylase activity by CNS β-endorphin in rat pups. Mol. Brain Res. 33, 149.
6. Berger, F.G., Szymanski, P., Read, E., Watson, G., 1984. Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney. J. Biol. Chem. 259, 7941.
7. Bianchi, M., Marini, A., Sacerdote, P., Cocco, E., Brini, A., Panerai, A.E., 1988. Effect of chronic morphine on plasma and brain β-endorphin and methionine enkephalin in pregnant rats and in their fetuses or newborn. Neuroendocrinology 47, 89.
8. Butcher, M.L.R., Patel, U., Cohen, S., 1978. Hormonal factors concerned with liver regeneration. In: Porter, R., Whelan, J. (Eds.), Hepatotrophic Factors. CIBA Foundation Symposium 55. Elsevier, New York, p. 95.
9. Chasnoff, I.J., 1985. Effects of maternal narcotic vs. nonnarcotic addiction on neonatal neurobehavior and infant development. In: T.M. Pinker (Ed.), Consequences of Maternal Drug Abuse. National Institute on Drug Abuse, Washington, DC, p. 84.
10. Chomczynski, P., Sacchi, N., 1987. Single-step method for RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156.
11. Christensen, H.E., Fairchild, E.J., Caroll, B.S., Lewis, R.J., 1976. Registry of Toxic Effects of Chemical Substances. U.S. Department of Health Education and Welfare, Baltimore, MD, p. 729.
12. Csontos, K., Rust, M., Höllt, V., Mahr, W., Kromer, W., Teschemacher, H.J., 1979. Elevated plasma β-endorphin levels in pregnant women and their neonates. Life Sci. 25, 835.
13. Gianoulakis, G., 1986. Effect of maternally administered opiates on the development of the beta-endorphin system in the offspring. NIDA Res. Monogr. 75, 595.
14. Greer, N.L., Schanberg, S.M., Bartolome, J.V., 1991. Effect of central administration of β-endorphin on lung ornithine decarboxylase activity in developing rats. Pediatr. Res. 29, 182.
15. Haley, T.J., McCormick, W.G., 1957. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12, 12.
16. Hauser, K.F., 1992. Morphine regulates DNA synthesis in rat cerebellar neuroblasts in vitro. Dev. Brain Res. 70, 291.
17. Heby, O., 1981. Role of polyamines in the control of cell proliferation and differentiation. Differentiation 19, 1.
18. Hölttä, E., Pohjanpelto, P., 1986. Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. J. Biol. Chem. 261, 9502.
19. Hulchings, D.E., 1991. Opiates during pregnancy: Neurobehavioral effects in the offspring. Adv. Biosci. 80, 285.
20. Johanson, C.E., 1980. Permeability and vascularity of the developing brain: Cerebellum vs cerebral cortex. Brain Res. 190, 3.
21. Kahana, C., Nathans, D., 1985. Translational regulation of mammalian ornithine decarboxylase by polyamines. J. Biol. Chem. 260, 15390.
22. Kahn, C.R., Neville, D.M. Jr, Roth, J., 1973. Insulin-receptor interaction in the obesehyperglycemic mouse. J. Biol. Chem. 248, 244.
23. Katz, A., Kahana, C., 1987. Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth. Mol. Cell. Biol. 7, 2641.
24. Kornblum, H.I., Loughlin, S.E., Leslie, F.M., 1987. Effects of morphine on DNA synthesis in neonatal rat brain. Dev. Brain Res. 31, 45.
25. Metcalf, B.W., Bey, P., Danzin, C., Jung, M.J., Casara, P., Vevert, J.P., 1978. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (B.C. 4.1.1.17) by substrate and products analogues. J. Am. Chem. Soc. 100, 2551.
26. Moss, I.R., Conner, H., William, B.A., Yee, F.H., Iorio, P., Scarpelli, E.M., 1982. Human β-endorphin-like immunoreactivity in the perinatal/neonatal period. J. Pediatr. 101, 443.
27. Naeye, R.L., Blanc, W., Leblanc, W., Khatamee, M.A., 1973. Fetal complications of maternal heroin addiction: Abnormal growth, infections, and episodes of stress. J. Pediatr. 83, 1055.
28. Oldendorf, W.H., Hyman, S., Braun, L., Oldendorf, S.Z., 1972. Blood-brain barrier. Penetration of morphine, codeine, heroin and methadone after carotid injection. Science 176, 984.
29. Olkkola, K.T., Maunuksela, E.-L., Korpela, R., Rosenberg, P.H., 1988. Kinetics and dynamics of postoperative intravenous morphine in children. Clin. Pharmacol. Ther. 44, 128.
30. Panerai, A.E., Martini, A., DiGiulio, A.M., Fraioli, F., Vegni, C., Pardi, G., Marini, A., Mantegazza, P., 1983. Plasma β-endorphin, β-lipotropin, and met-enkephalin concentrations during pregnancy in normal and drug-addicted women and their newborn. J. Clin. Endocrinol. Metab. 57, 537.
31. Pegg, A.E., McCann, P.P., 1982. Polyamine metabolism and function. Am. J. Physiol. 243, C212.
32. Pegg, A.E., Williams-Ashman, H.G., 1968. Biosynthesis of putrescine in the prostate gland of the rat. Biochem. J. 100, 533.
33. Piik, K., Poso, H., Janne, J., 1978. Reversible inhibition of rat lvier regeneration by 1,3-diamino-2-propanol, an inhibitor of ornithine decarboxylase. FEBS Lett. 89, 307.
34. Pohjanpelto, P., Hölttä, E., Jänne, O.A., Knuutila, S., Alitalo, K., 1985. Amplification of ornithine decarboxylase gene in response to polyamine deprivation in Chinese hamster ovary cells. J. Biol. Chem. 260, 8532.
35. Russell, D.H., 1980. Ornithine decarboxylase as a biological and pharmacological tool. Pharmacology 20, 117.
36. Russell, D.H., 1985. Ornithine decarboxylase: A key regulatory enzyme in normal and neoplastic growth. Drug Metab. Rev. 16, 1.
37. Sherman, B.M., Stagner, J.I., Zamudio, R., 1977. Regulation of lactogenic hormone binding in rat liver by steroid hormones. Endocrinology 100, 101.
38. Slotkin, T.A., 1979. Ornithine decarboxylase as a tool in developmental neurobiology. Life Sci. 24, 1623.
39. Slotkin, T.A., Bartolome, J., 1983. Ornithine decarboxylase: Marker of neuroendocrine and neurotransmitter actions. Methods Enzymol. 103, 59.
40. Slotkin, T.A., Bartolome, J., 1986. Role of ornithine decarboxylase and the polyamines in nervous system development: A review. Brain Res. Bull. 17, 307.
41. Slotkin, T.A., Seidler, F.J., Trepanier, P.A., Whitmore, W.L., Lerea, L., Barnes, G.A., Weigel, S.J., Bartolome, J., 1982. Ornithine decarboxylase and polyamines in tissues of the neonatal rat: Effects of α-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase. J. Pharmacol. Exp. Ther. 222, 741.
42. Wen, L., Huang, J.-K., Blackshear, P.J., 1989. Rat ornithine decarboxylase gene. J. Biol. Chem. 264, 9016.
43. Wilson, G.S., 1992. Heroin use during pregnancy: Clinical studies of long-term effects. In: Sonderegger, T.B. (Ed.), Perinatal Substance Abuse. The Johns Hopkins University Press, Baltimore, MD, p. 224.
44. Windh, R.T., Little, P.J., Kuhn, C.M., 1995. The ontogeny of μ opiate tolerance and dependence in the rat: Antinociceptive and biochemical studies. J. Pharmacol. Exp. Ther. 273, 1361.
45. Zagon, I.S., McLaughlin, P.J., 1992. The perinatal opioid syndrome: Laboratory findings and clinical implications. In: Sonderegger, T.B. (Ed.), Perinatal Substance Abuse. The Johns Hopkins University Press, Baltimore, MD, p. 207.
46. Zelson, C., Rubio, E., Wasserman, E., 1971. Neonatal narcotic addiction: 10 year observation. Pediatrics 48, 178.