Enzymatic resolution of (±)-cis-3-(2,2-dichloro-3,3,3-trifluoropropyl)-2,2-dimethylcyclopropane carboxylate

Tetrahedron Asymmetry

Volumn 8, Issue 14, 1997, Pages 2291-2294

  Yadav, J S ^a   Bhaskar Rao, A ^a   Ravindra Reddy, Y ^a   Venkata Rami Reddy, K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; INSECTICIDE;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY;

EID: 0030841359     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00251-6     Document Type: Article

References (15)

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11. a) European Patent: Insecticidal Product and Preparation thereof. Pat. No. 83305005.7, dated 31-08-1983, Robson, Michael John and Crosby John; b) United Kingdom Patent: Isolation of Cisisomers from isomeric Mixtures of Cis/Trans Cyclopropane Carboxylates, patent No. 90171851, dated 06-08-1990, Raymond, M. Palmure and Thomas E Quvahkl.
12. Lipase obtained from Candida cylindreacea, Type VII; Pseudomonas fluorescens Type II and Procine pancreatic lipase (PPL) Type II obtained from Sigma Chemical Co., USA. Specific activity of the enzymes ranges from 75U-175U/mg protein (Biuret).
13. D=+10 (cone= 1.0 methanol).
14. Bhaskar Rao, A., Rahman, H., Kumari, B.K., and Yadav, J.S. Tetrahedron Lett., (1994) 35, 2611; Indian Patent No. 433/DEL/94 (1994).
15. Time course of reaction (compound Ib) at different time intervals showing relative concentration of acid and its ester quantified by GC (Hewlett Packard 5890 Mixed Column OV 17 and OV 1 (8 feet × 1/8 inch dia).