An efficient catalytic stereoselective route to a key intermediate for the synthesis of the long-lived PGI2 analog ZK 96480 (Cicaprost(TM))

Tetrahedron Letters

Volumn 38, Issue 43, 1997, Pages 7511-7514

  Corey, E J ^a   Helal, Christopher J ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CICAPROST; PROSTACYCLIN DERIVATIVE;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; IN VITRO STUDY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030841352     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01803-0     Document Type: Article

References (27)

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25. t: 29.8 min, major; 35.6 min, minor).
26. The relative stereochemistry of the reduction of ketone 14 to alcohol 2 was assigned by analogy with the reduction of ketone 6 to alcohol 8.
27. This research was supported by grants from the National Institutes of Health and the National Science Foundation.