Chemical modification of L-asparaginase with comb-shaped copolymer of poly(ethylene glycol) derivative and maleic anhydride

Leukemia

Volumn 11, Issue SUPPL. 3, 1997, Pages 408-409

  Saito, Tetsuya ^a   Ueno, Tomoo ^a   Sekine, Taichi ^a   Kodera, Yoh ^a   Hiroto, Misao ^a   Matsushima, Ayako ^a   Nishimura, Hiroyuki ^a   Inada, Yuji ^a  

^a TOIN UNIVERSITY OF YOKOHAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; BACTERIAL ENZYME; COPOLYMER; MACROGOL; MALEIC ANHYDRIDE;

ANIMAL EXPERIMENT; CHEMICAL MODIFICATION; CONFERENCE PAPER; ENZYME ACTIVITY; ESCHERICHIA COLI; IMMUNOREACTIVITY; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030841324     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Clarkson B et al. Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma and solid tumors. Cancer, 1970; 25: 279-305.
2. Ertell J et al. Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from a children's cancer study group. Cancer Res, 1979; 39: 3893-3896.
3. 2); Disappearance of binding ability towards antiserum and retention of enzymic activity. Chem Lett 1980; 773-776.
4. Kamisaki Y et al. Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol. J Pharmacol Exp Ther, 1981; 216: 410-414.
5. Kodera Y et al. Chemical modification of L-asparaginase with a comb-shaped copolymer of polyethylene glycol derivative and maleic anhydride. Biochem Biophys Res Commun, 1992; 184: 144-148.
6. Maita T et al. Amino acid sequence of L-asparaginase from Escherichia coli. J Biochem, 1974; 76: 1351-1354.
7. Kodera Y et al. Stabilization of L-asparaginase modified with comb-shaped poly(ethylene glycol) derivatives, in vivo and in vitro. Bioconjugate chem, 1994; 5: 283-286.
8. Sekine T et al. L-asparaginase modified by poly(ethylene glycol) derivative with a comb-shaped form: antitumor activity and induction of immune tolerance. Biomedical Res, 1995; 16: 121-123.