Comparative clinical evaluation of the effect on carbohydrate and lipid metabolism of two norethisterone-containing hormonal contraceptives: Mesigyna and TriNovum

Contraception

Volumn 55, Issue 5, 1997, Pages 295-300

  Benagiano, G ^a   Primiero, Francesco M ^a,c   Bastianelli, C ^a   Bianchi, P ^a   Medda, E ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c POLICLINICO UMBERTO I   (Italy)

Author keywords

Carbohydrate metabolism; Lipid metabolism; Mesigyna; TriNovum

Indexed keywords

CARBOHYDRATE; CHOLESTEROL; CONTRACEPTIVE AGENT; ESTRADIOL VALERATE PLUS NORETHISTERONE ENANTATE; ETHINYLESTRADIOL PLUS NORETHISTERONE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CARBOHYDRATE METABOLISM; CLINICAL TRIAL; CONTRACEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; LIPID METABOLISM; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; CONTRACEPTIVE AGENTS, FEMALE; CONTRACEPTIVES, ORAL, COMBINED; CONTRACEPTIVES, ORAL, HORMONAL; DRUG COMBINATIONS; ESTRADIOL; ETHINYL ESTRADIOL; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; LIPIDS; NORETHINDRONE; PREGNANCY; TRIGLYCERIDES;

EID: 0030841242     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(97)00033-4     Document Type: Article

References (36)

1. Pincus G, Garcia CR, Rock J, et al. Effectiveness of an oral contraceptive. Science 1959;130:81.
2. Siegel I. Conception control by long-acting progestogens: preliminary report. Obstet Gynecol 1963;21:666.
3. World Health Organization, Special Programme of Research, Development and Research Training in Human Reproduction. Tenth Annual Report, 1981.
4. Oriowo MA, Landgren B-M, Stenstrom B, Diczfalusy E. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception 1980;21:415.
5. World Health Organization, Task Force on Long-Acting Systemic Agents for Fertility Regulation, Special Programme of Research, Development and Research Training in Human Reproduction. A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection: I. Contraceptive efficacy and side effects. Contraception 1988;37:1.
6. Sang GW, Shao QX, Ge RS, et al. A multicentred phase III comparative clinical trial of Mesigyna, Cyclofem and Injectable No. 1 given by intramuscular injection to Chinese women. I. Contraceptive efficacy and side effects. Contraception 1995;51:167.
7. Sang GW, Shao QX, Ge RS, et al. A multicentred phase III comparative clinical trial of Mesigyna, Cyclofem and injectable no. 1 given by intramuscular injection to Chinese women. II. The comparison of bleeding patterns. Contraception 1995;51:185.
8. Gaspard UJ, Lefebvre PJ. Clinical aspects of the relationship between oral contraceptives, abnormalities of carbohydrate metabolism and the development of cardiovascular disease. Am J Obstet Gynecol 1990;163: 334.
9. Ducimetière P, Eschwage E, Papoz L, Richard JL, Claude JR, Roschin GE. Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population. Diabetologia 1990;19:205.
10. La Rosa JC. The varying effects of progestins on lipid levels and cardiovascular disease. Am J Obstet Gynecol 1988;158:1621.
11. Newman WP, Freedman DS, Voors AW, et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bagalusa Heart Study. N Engl J Med 1986;314:138.
12. Hirvonen E, Malkonen M, Manninen V. Effects of different progestogens on lipoproteins during post menopausal replacement therapy. N Engl J Med 1981; 304:560.
13. De Fronzo R, Tobin J, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214.
14. Henry RJ, Cannon DS, Winckelman JW. Clinical Chemistry. Principles and Techniques. Hagerstown: Harper & Row, 1974.
15. Cooper C. Manual of Laboratory Operations. Lipid Research Clinic Program. Vol. I. National Heart and Lung Institute, USA, 1974.
16. Stambury JB, Wyngaarden JB, Fredrickson DS. The Metabolic Basis of Inherited Disease. 2nd Ed. New York: McGraw-Hill Book Co., 1966.
17. Fahmy K, Abdel-Razik M, Shaaraway M, et al. Effect of long-acting progestagen-only injectable contraceptives on carbohydrate metabolism and its hormonal profile. Contraception 1991;44:419.
18. McEwan JA, Griffin M, Fotherby K, Trayner I. Long-term use of depot-norethisterone enanthate: effect on blood lipid fractions. Contraception 1992;46:49.
19. Dhall K, Kumar M, Rastogi G, Devi P. Short-term effects of norethisterone enanthate and medroxyprogesterone acetate on glucose, insulin, growth hormone and lipids. Fertil Steril 1977;28:156.
20. Amatayakul K, Suriyanon V. The effect of long-acting injectable contraceptives on carbohydrate metabolism. Int J Gynecol Obstet 1985;23:361.
21. Howard G, Elder MG. The effect of intramuscular norethisterone enanthate on intravenous glucose tolerance and blood coagulation factors VII and V. Br J Obstet Gynaecol 1977;84:618.
22. Howard G, Blair M, Fotherby K, Trayner I, Hamawi A, Elder MG. Some metabolic effects of long-term use of the injectable contraceptive norethisterone enanthate. Lancet 1982;1:423.
23. Fotherby K, Trayner I, Howard G, Hamawi A, Elder MG. Effect of injectable norethisterone oenanthate (Norigest) on blood lipid levels. Contraception 1982;25: 435.
24. Fotherby K. Metabolic effects of injectable contraceptives. Br J Clin Pract 1982;17(Suppl.):2G.
25. Spellacy WN. Carbohydrate metabolism in male infertility and female fertility-control patients. Fertil Steril 1976;27:1132.
26. Bowes WA, Katta LR, Droegemueller W, Bright TG. Triphasic randomized clinical trial: comparison of effects on carbohydrate metabolism. Am J Obstet Gynecol 1989;161:1402.
27. Loke DFM, Ng CSA, Holck S, Hall PE, Ratnam SS. Lipid and biochemical changes after low-dose oral contraception. Contraception 1992;46:227.
28. Burkman RT, Zacur HA, Kimball AW, Kwiterovich P, Bell WR. Oral contraceptives and lipids and lipoproteins. Part II: relationship to plasma steroid levels and outlier status. Contraception 1989;40:675.
29. Kakis G, Powell M, Marshall A, Steiner G. A randomized, comparative open study of the effects of two oral contraceptives, Triphasil and Ortho 7/7/7, on lipid metabolism. Contraception 1993;47:131.
30. Notelovitz M, Levenson I, McKenzie L, Khan FY. The effect of low-dose oral contraceptives on lipid and lipoproteins in two at-risk populations: young female smokers and older premenopausal women. Contraception 1991;44:505.
31. Haiba NA, El-Habashy MA, Said SA, Darwish EA, Abel-Sayed WS, Nayel SE. Clinical evaluation of two monthly injectable contraceptives and their effects on some metabolic parameters. Contraception 1989;39: 619.
32. Jiang HY, Yang H, Zhang MY, Lu FY, Gu LJ. Effects of long-term use of two monthly injectable contraceptives on carbohydrate metabolism and liver function. Chin J Fam Plann 1992;1:28.
33. Kesserü E, Albornoz H, Diaz M, Socolsky R. Serum lipid variations in women on copper intrauterine devices, triphasic oral contraceptives and monthly injectable contraceptives. Contraception 1991;44:13.
34. Yang H, Zhang MY, Lu FY, Jiang HY. The effect of a monthly injectable contraceptive on serum lipids in Chinese women. Reprod Contraception (Beijing) 1994; 14:427.
35. WHO Special Programme of Research, Development and Research Training in Human Reproduction. Comparative study of two once-a-month injectable steroidal contraceptives (Mesigyna and Cyclofem) on lipid, lipoprotein, and apolipoprotein metabolism. Contraception. In press.
36. Manson JE, Willett WC, Stampfer MJ, et al. Body weight and mortality among women. NE J Med 1995; 333:677.