Polysaccharopeptide from the mushroom Coriolus versicolor possesses analgesic activity but does not produce adverse effects on female reproductive or embryonic development in mice

General Pharmacology

Volumn 29, Issue 2, 1997, Pages 269-273

  Ng, T B ^a   Chan, W Y ^a  

^a Prince of Wales Hospital   (Hong Kong)

Author keywords

Analgesic; Embryonic development; Polysaccharopeptide

Indexed keywords

ANALGESIC AGENT; ANTINEOPLASTIC AGENT; CORIOLUS VERSICOLOR EXTRACT; IMMUNOMODULATING AGENT; MORPHINE; PLANT EXTRACT; POLYSACCHARIDE; RIBOSOME INACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; AXIS; BODY HEIGHT; BRANCHIAL ARCH; CEPHALOMETRY; CONTROLLED STUDY; EAR; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; FEMALE; FEMALE GENITAL SYSTEM; FORELIMB; HEART BEAT; HOT PLATE TEST; INTRAPERITONEAL DRUG ADMINISTRATION; LIMB BUD; MOUSE; MUSHROOM; NEURAL TUBE; NONHUMAN; OPTIC DISK CUP; OVARY FUNCTION; OVULATION; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY; SOMITE; STEROIDOGENESIS; TOXICITY TESTING; YOLK SAC;

ANALGESICS; ANIMALS; BASIDIOMYCOTA; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; MICE; MICE, INBRED ICR; PREGNANCY; PROTEOGLYCANS; REPRODUCTION;

EID: 0030841184     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00412-0     Document Type: Article

References (28)

1. Abe Y. (1990) The induction of cytokines by PSK in the peripheral mononuclear cell culture. J. Jpn. Soc. Cancer Therapy 25, 128.
2. Chan W. Y., Ng T .B., Wu P. J. and Yeung H. W. (1993) Developmental toxicity and teratogenicity of trichosanthin, a ribosome-inactivating prorein, in mice. Teratog. Carcinog. Mutagen. 13, 47-57.
3. Chan W. Y., Ng T. B. and Yeung H. W. (1994) Differential abilities of the ribosome inactivating proteins luffaculin, luffins and momorcochin to induce abnormalities in developing embryos in vitro. Gen. Pharmac. 25, 363-367.
4. Chan W. Y., Tam P. P. L., Choi H. L., Ng T. B. and Yeung H. W. (1986) Effects of momorcharins on the mouse embryo at the early organogenesis stage. Contraception 34, 537-544.
5. Chiu L. C. M., Ooi V. E. C. and Yeung J. H. K. (1993) Studies of hepatoprotective mechanisms of polysaccharopeptide on paracetamol-induced hepatotoxicity in rats. In Programme and Abstracts, First International Conference on Mushroom Biology and Mushroom Products (Edited by Chang S. T.), p. 96. Chinese University Press, Hong Kong.
6. Hirase S., Nakai S., Akatsu T., Kobayashi A., Oohara M., Matsunaga K., Fujii M. and Ohmura Y. (1970) Studies on antitumor activity of polysaccharides. Proc. Jpn. Canc. Assoc. 29th Annu. Meeting, p. 288.
7. Hiroshi S. and Minorn T. (1993) Diverse biological activities of PSK (Krestin), a protein-bound polysaccharide from Coriolus versicolor (Fr) Quel. In Mushroom Biology and Products (Edited by Chang S. T., Buswell J. A. and Chiu S. W.), pp. 237-245.
8. Kono H. (1990) The effects of PSK on recovering the impairment of host immunity induced by long-term chemotherapy. J. Jpn. Soc. Cancer Therapy 25, 385.
9. Koyama K., Kinoshita K., Imaizumi T., Akiba Y., Negishi E., Takahashi K., Suzuki A., Watanabe K., Yano S., Horie S. and Naoi Y. (1993) Analgesic activity of triterpenoids and steroid isolated from mushrooms. In Programme and Abstracts, First International Conference on Mushroom Biology and Mushroom Products (Edited by Chang S. T.), p.138. Chinese University Press, Hong Kong.
10. Liao M. L. and Zhao J. M. (1993) Stage II clinical tests of PSP in the treat-ment of lung cancer. In Proceedings of International Symposium on PSP (Edited by Yang Q. Y. and Kwok C. Y.), pp. 243-256. Fudan University Press, Shanghai, China.
11. Liu T. H. (1993) Role of PSP in the radiation treatment of esophagus cancer. In Proceedings of International Symposium on PSP (Edited by Yang Q. Y. and Kwok C. Y.), pp. 224-231. Fudan University Press, Shanghai, China.
12. Liu W. K., Ng T. B., Sze S. F. and Tsui K. W. (1993) Activation of peritoneal macrophages by polysaccharopeptide from the mushroom Coriolus versicolor. Immunopharmacology 26, 139-146.
13. Ng T. B., Chan W. Y., Sze L. Y. and Yeung H. W. (1991) Trichosanthin induces atresia of ovarian follicles and inhibits steroidogenesis in gonado-tropin-primed immatute mice. Gen. Pharmac. 22, 847-849.
14. Ng T. B., Chan W. Y. and Yeung H. W. (1994) Changes in ovulatory and steroidogenic responses in mice after administration of the ribosome in-activating proteins momorcochin, luffaculin and luffins. Gen. Pharmac. 25, 19-21.
15. Ng T. B., Cheng C. H. K. and Hui S. T. Y. (1993) Peripheral administration of taurine antagonizes morphine-induced analgesia in mice. Gen. Pharmac. 24, 311-314.
16. Ng T. B., Tam P. P. L., Hon W. K., Choi H. L. and Yeung H. W. (1988) Effects of momorcharins on ovarian response to gonadotropin-induced superovulation in mice. Int. J. Fertil. 33, 123-128.
17. Pederson T. and Peter H. (1968) Proposal for a classification of oocytes and follicles in the mouse ovary. J. Reprod. Fertil. 17, 555-557.
18. Quinn P., Barros C. and Whittingham D. G. (1982) Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa. J. Reprod. Fertil. 66, 161-168.
19. Sadler T. W. (1979) Culture of early somite mouse embryos during organo-genesis. J. Embryol. Exp. Morphol. 49, 17-25.
20. Shi J. H., Chen T. and Lian Z. R. (1993) Clinical research of the effect of PSP on the immunological function of stomach cancer patients during operation and chemotherapy. Proceedings of International Symposium on PSP (Edited by Change S. T.), pp. 232-240. Fudan University Press, Shanghai, China.
21. Tsao S. W., Ng T. B. and Yeung H. W. (1990) Toxicities of trichosanthin and α-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines. Toxicon 28, 1183-1192.
22. Whittingham D. G. and Wales R. G. (1969) Storage of 2-cell mouse embryos in vitro. Aust. J. Biol. Sci. 22, 1065-1068.
23. Xu L. Z., Han J. and Chen G. (1993a) Anticancer effect of purified PSP products and KS-2 on human tumor cell lines in vitro. Proceedings of International Symposium on PSP (Edited by Chang S. T.), pp. 73-79. Fudan University Press, Shanghai, China.
24. Xu M. F., Guy Z. L., Qian Z. N., Chou W. H. And Kwok C. Y. (1993b) The effect of PSP on the immunological function of rats. Proceedings of International Symposium on PSP (Edited by Chang S. T.), pp. 132-136. Fudan University Press, Shanghai, China.
25. Yang M. M. P., Chen Z. N., Kwok S. L. And Ge H. (1993a) The antitumor effect on purified PSP (PCV) in vitro and in vivo. Proceedings of International Symposium on PSP (Edited by Chang S. T.), pp. 80-96. Fudan University Press, Shanghai, China.
26. Yang Q. Y. (1993) A brief introduction to the research of PSP. Proceedings of International Symposium on PSP (Edited by Chang S. T.), pp. 14-21. Fudan University Press, Shanghai, China.
27. Yang Q. Y., Jong S. C., Zhou J. X., Li X. Y., Chen R. T., Xu L. Z. and Xu B. (1993b) Antitumor and immunomodulating activities of polysaccharide peptide (PSP) of Coriolus versicolor. Proceedings of International Symposium on PSP (Edited by Chang S. T.), pp. 109-119. Fudan University Press, Shanghai, China.
28. Yeung H. W., Li W. W., Chan W. Y., Law L. K. and Ng T. B. (1986) Alpha-and beta-momorcharins: abortifacient proteins from the seeds of the bitter gourd Momordica charantia (family Cucurbitaceae). Int. J. Pept. Protein Res. 28, 518-524.