Syn-Selective Michael Addition of Amines to Bis-Enones: Synthesis of 1,3,4,7-Tetrasubstituted (4R,5S,6S,7R)-Hexahydro-5,6-dihydroxy-2H-1,3-diazepin-2-ones

Journal of Organic Chemistry

Volumn 62, Issue 16, 1997, Pages 5380-5384

  Schreiner, Erwin P ^a   Pruckner, Arno ^a  

^a Brunnerstra e 59   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR; UREA DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0030841156     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo970384k     Document Type: Article

References (11)

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10. Reduction of viscosity of the reaction mixture to allow magnetically stirring at -50°C was achieved by addition of low amounts of dichloromethane.
11. 6a,b were the starting materials for a multitude of HIV-1 protease inhibitors by transformation of the ester group.