Therapeutic effect of co-enzyme Q10 on idiopathic dilated cardiomyopathy: Assessment by iodine-123 labelled 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid myocardial single-photon emission tomography

European Journal of Nuclear Medicine

Volumn 24, Issue 6, 1997, Pages 629-634

  Kim, Yong Ih ^a   Sawada, Yoshihiro ^a   Fujiwara, Go ^a   Chiba, Hiroshi ^b   Nishimura, Tsunehiko ^c  

^a Nishiyodo Hospital   (Japan)

^b Mimihara General Hospital   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Co enzyme Q10; Echocardiography; Idiopathic dilated cardiomyopathy; Iodine 123 labelled 15 (p iodophenyl) 3 (R,S) methylpentadecanoid acid; Single photon emission tomography

Indexed keywords

15 (4 IODOPHENYL)PENTADECANOIC ACID I 123; CARDIOTONIC AGENT; TRACER; UBIDECARENONE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DRUG EFFICACY; ECHOCARDIOGRAPHY; FEMALE; HEART MITOCHONDRION; HEART MUSCLE METABOLISM; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEDIASTINUM; SCORING SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

CARDIOMYOPATHY, DILATED; ECHOCARDIOGRAPHY; FATTY ACIDS; FEMALE; HEART; HUMANS; IODINE RADIOISOTOPES; IODOBENZENES; MALE; MIDDLE AGED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; UBIQUINONE;

EID: 0030841031     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050097     Document Type: Article

References (25)

1. Yamumichi Y, Kusuoka H, Morishita K, Shirakami Y, Kurami M, Okano K, Itoh O, Nishimura T. Metabolism of iodine-123-BMIPP in perfused rat heart. J Nucl Med 1995; 36: 1043-1050.
2. Knapp FF, Kropp J. Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives. Eur J Nucl Med 1995; 22: 361-381.
3. Fujibayashi Y, Yonekura T, Takemura Y, Wada K, Matsumoto K, Tamaki N, Konishi J, Yokoyama A. Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) in relation to ATP concentration. J Nucl Med 1990; 31: 1818-1822.
4. 125I-BMIPP in rats treated with adriamycin. Jpn J Nucl Med 1989; 26: 69-76.
5. 123I)-iodophenyl-pentadecanoic acid, a myocardial imaging agent for evaluating myocardial fatty acid metabolism. Jpn J Nucl Med 1992; 29: 305-317.
6. 123I)-iodophenyl-pentadecanoic acid, a myocardial imaging agent for evaluating myocardial fatty acid metabolism-A multi-center trial-. Jpn J Nucl Med 1992; 29: 413-433.
7. Hatefi Y, Haavik AG, Griffiths DE. Reconstitution of the electron transport. Biochem Biophys Res Commun 1961; 4: 447-453.
8. Azuma j, Suwamuru A, Awata N. Usefulness of Taurin in chronic congestive heart failure and its prospective application. Jpn Circ J 1992; 95-99.
9. Folkers K, Littarru GP, Runge TM, Havanonda S, Colley D. Evidence for a deficiency of coenzyme Q10 in human heart disease. Int J Vitam Nutr Res 1970; 40: 380-390.
10. Dohmae M, Sawada H, Tashima M, Uchino H, Matsuyama E, Konishi T. Chronic toxicites adriamycin (ADR) and their possible prevention by coenzyme Q10. J Jpn Soc Cancer Ther 1979; 14: 1009-1028.
11. Nagai S, Miyazaki Y, Ogawa K, Satake T, Sugiyama S, Ozawa T. The effect of coenzyme Q10 on reperfusion injury in canine myocardium. J Mol Cell Cardiol 1985; 17: 873-894.
12. Ogasawara S, Nishikawa Y, Yorifuji S, Soga T, Nakamura Y, Takahashi M, Tarui K. Treatment of Kearn-Sayre syndrome with coenzyme Q10. Neurology 1986; 36: 45-53.
13. Langsjoen P, Vadhanavikit S, Folkers K. Response of patients in classes II and IV of cardiomyopathy to therapy in a blind and crossovers trial with coenzyme Q10. Proc Natl Acad Sci USA 1985; 82: 4240-4244.
14. Ichihara T, Ogawa K, Motomura N, Kubo A, Hashimoto S. Computer scatter compensation using the triple energy window method for single and dual isotope SEPCT. J Nucl Med 1993; 34: 2216-2221.
15. Hashimoto A, Nakata T, Tsuchihashi K, Tanaka S, Fujimori K, Iimura O. Postischemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. Am J Cardiol 1996; 77: 25-30.
16. Tamaki N, Kawamoto M, Yonekura Y, Fujibayashi Y, Takahashi N, Konishi J, Nohara K, Kambara H, Kawai C, Ikekubo K, Kato H. Regional metabolic abnormality in relative to perfusio and wall motion in patients with myocardial infarction: assessment with emission tomography using an iodinated branched fatty acid analog. J Nucl Med 1992; 33: 659-667.
17. 123I-BMlPP myocardial imaging for myocardial infarction and hypertrophic cardiomyopathy. Ann Nucl Med 1993; 7: SII-35-SI-39
18. Kurata C, Kobayashi A, Yamazaki N. Dual tracer autoradiographic study with thullium-201 and radioiodinated fatty acid in cardiomyopathic hamsters. J Nucl Med 1989; 30: 80-87.
19. Barrie SE, Saad EA, Lacaz P, Da Sira, Harris P. Myocardial enzyine activites in congestive cardiomyopathy. Res Commun Chem Pathol Pharmacol 1979; 23: 375-381.
20. Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA 1985; 82: 901-904.
21. Kadowaki T, Kadowaki H, Mori T, Tobe K, Sakuta R, Sasaki Y, Tanahe Y, Sakura H, Awata T, Goto Y, Akanuma Y, Yazaki Y. A subtype of diabetes mellitus associated with a mutation in the mitochondrial gene. N Engl J Med 1994; 330: 962-968.
22. Suzuki Y, Moriyama Y, Atsumi Y, Katagiri H, Kadowaki T, Oka Y, Hosokawa K, Kimura M, Matsuoka K. A case of mitochondrial diabetes mellitus with various autonomic symptoms and subclinical cardiac dysfunction. J Jpn Diab Soc 1995; 38: 39-44.
23. Lenaz G, Daves GD, Folkers K. Organic structural specificity and sites of coenzyme Q10 in succinoxidase and DPNH-oxidase systems. Arch Biochem Biophys 1968; 123: 539-550.
24. Choe JY, Combs AB, Saji S, Folkers K. Study of the combined and separate administration of doxorubicin and coenzyme Q10 on mouse cardiac enzymes. Res Commun Chem Pathol Pharmacol 1979; 24: 595-598.
25. Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990; 65: 521-523.