Is the effect of acute hyperglycaemia on interdigestive antroduodenal motility and small-bowel transit mediated by insulin?

European Journal of Clinical Investigation

Volumn 27, Issue 8, 1997, Pages 703-710

  Gielkens, H A J ^a   Verkijk, M ^a   Frolich M ^a   Lamers, C B H W ^a   Masclee, A A M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Abbreviations; Gastrointestinal motility; Hyperglycaemia; Hyperinsulinaemia; Small bowel transit time

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DUODENUM MOTILITY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INTESTINE TRANSIT TIME; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH ANTRUM; STOMACH MOTILITY;

EID: 0030840496     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1997.1680723.x     Document Type: Article

References (30)

1. MacGregor IL, Deveney C, Way LW, Meyer JH. The effect of acute hyperglycemia on meal-stimulated gastric, biliary, and pancreatic secretion, and serum gastrin. Gastroenterology 1976;70:197-202.
2. MacGregor IL, Gueller R, Watts HD, Meyer JH. The effect of acute hyperglycemia on gastric emptying in man. Gastroenterology 1976;70:190-6.
3. de Boer SY, Masclee AAM, Lam WF, Schipper J. Jansen IBMJ, Lamers CBHW. Hyperglycemia modulates gallbladder motility and small intestinal transit time in man. Dig Dis Sci 1993;38:2228-35.
4. Øster-Jørgensen E, Pedersen SA, Larsen ML. The influence of induced hyperglycaemia on gastric emptying rate in healthy humans. Scand J Clin Lab Invest 1990;50:831-6.
5. de Boer SY, Masclee AAM, Lam WF et al. Effect of hyperglycaemia on gallbladder motility in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1994;37:75-81.
6. Fraser RJ, Horowitz M, Maddox AF, Harding PE, Chatterton BE, Dent J. Hyperglycaemia slows gastric emptying in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1990;33:675-80.
7. Barnett JL, Owyang C. Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology 1988;94:739-44.
8. Fraser R, Horowitz M, Dent J. Hyperglycaemia stimulates pyloric motility in normal subjects. Gut 1991;32:475-8.
9. Björnsson ES, Urbanavicius V, Eliasson B, Attvall S, Smith U, Abrahamsson H. Effects of hyperglycemia on interdigestive gastrointestinal motility in humans. Scand J Gastroenterol 1994;29:1096-104.
10. Björnsson ES, Urbanavicius V, Eliasson B, Attvall S, Smith U, Abrahamsson H. Effects of insulin and beta-adrenergic blockade on the migrating motor complex in humans. Scand J Gastroenterol 1995;30:219-24.
11. Eliasson B, Björnsson E, Urbanavicius V et al. Hyperinsulinaemia impairs gastrointestinal motilily and slows carbohydrate absorption. Diabetologia 1995;38:79-85.
12. Gielkens HAJ, Lam WF, Coenraad M, Biemond I, Lamers CBHW, Masclee AAM. Effect of insulin on pancreatico-biliary secretion during hyper- and normoglycemia (abstract). Gastroenterology 1996;110:A391.
13. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-23.
14. Ward WK, Halter JB, Beard JC, Porte D, Jr. Adaptation of B and A cell function during prolonged glucose infusion in human subjects. Am J Physiol 1984;246:E405-11.
15. Nijs HGT, Radder JK, Frölich M, Krans HMJ. In vivo relationship between insulin clearance and action in healthy subjects and IDDM patients. Diabetes 1990;39:333-9.
16. 2) measurements. J Lab Clin Med 1975;85:546-55.
17. Lamers CBHW, Diemel CM, Van Leer E, VanLeusen R, Peetoom JJ. Mechanism of elevated serum pancreatic polypeptide concentrations in chronic renal failure. J Clin Endocrinol Metab 1982;55:922-6.
18. Øster-Jørgensen E, Qvist N, Pedersen SA, Rasmussen L, Hovendal CP. The influence of induced hyperglycaemia on the characteristics of intestinal motility and bile kinetics in healthy men. Scand J Gastroenterol 1992;27:285-8.
19. Russo A, Fraser R, Horowitz M. The effect of acute hyperglycaemia on small intestinal motility in normal subjects. Diabetologia 1996;39:984-9.
20. Byrne M, Pluntke K, Wank U, Ehlenz K, Göke B, Schirra J, Katschinski M. Inhibitory effects of hyperglycemia and hyperinsulinemia on postprandial human jejunal motility (abstract). Gastroenterology 1996;110:A1061.
21. Kerlin P, Zinsmeister AR, Phillips S. Relationship of motility to flow of contents in the human small intestine. Gastroenterology 1982;82:701-6.
22. Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology 1986;91:386-95.
23. Schemann M, Ehrlein HJ. Mechanical characteristics of phase II and phase III of the interdigestive migrating motor complex in dogs. Gastroenterology 1986;91:117-23.
24. Bormans V, Peeters TL, Janssens J, Pearce D, Vandeweerd M, Vantrappen G. In man, only activity fronts that originate in the stomach correlate with motilin peaks. Scand J Gastroenterol 1987;22:781-4.
25. Qvist N, Øster-Jørgensen E, Pedersen SA, Rasmussen L, Hovendal C, Holst JJ. Increases in plasma motilin follow each episode of gallbladder emptying during the interdigestive period, and changes in serum bile acid concentration correlate to plasma motilin. Scand J Gastroenterol 1995;30:122-7.
26. Svenberg T, Christolides ND, Fitzpatrick ML, Areola-Ortiz F, Bloom SR, Welbourn RB. Interdigestive biliary output in man: relationship to fluctuations in plasma motilin and effect of atropine. Gut 1982;23:1024-8.
27. Lee KY, Park HJ, Chang TM, Chey WY, Cholinergic role on release and action of motilin. Peptides 1983;4:375-80.
28. Schwartz TW. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology 1983;85:1411-25.
29. Qvist N, Øster-Jørgensen E, Rasmussen L et al. Cholecystokinin. secretin, pancreatic polypeptide in relation to gallbladder dynamics and gastrointestinal interdigestive motility. Digestion 1990;45:130-7.
30. Hirano T, Niijima A. Effects of 2-deoxy-D-glucose, glucose and insulin on efferent activity in gastric vagus nerve. Experientia 1980;36:1197-8.