Hirudin in acute coronary syndromes: When cents override good sense

Journal of Thrombosis and Thrombolysis

Volumn 4, Issue 3-4, 1997, Pages 325-327

  Brieger, David ^a   Topol, Eric ^a,b  

^a JACOBS ENGINEERING   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acute coronary syndromes; Heparin; Hirudin

Indexed keywords

HEPARIN; HIRUDIN; STREPTOKINASE; THROMBIN;

ACUTE HEART INFARCTION; ANTICOAGULATION; BLEEDING; CLINICAL TRIAL; DRUG COST; DRUG EFFICACY; DRUG HYPERSENSITIVITY; HEART MUSCLE ISCHEMIA; HEART REINFARCTION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PATIENT CARE; PRIORITY JOURNAL; RISK; SHORT SURVEY; TREATMENT OUTCOME; UNSTABLE ANGINA PECTORIS;

EID: 0030840428     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008832913207     Document Type: Short Survey

References (12)

1. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996;335:775-782.
2. Antmam EM, for the TIMI 9B Investigators. Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation 1996;94:911-921.
3. Hirsh J. Heparin. N Engl J Med 1991;324:1565-1574.
4. Topol EJ, Fuster V, Harrington RA, et al. Recombinant hirudin for unstable angina pectoris: A multicenter, randomized angiographic trial. Circulation 1994;89:1557-1556.
5. Cannon CP, McCabe CH, Henry TD, et al. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) 5 trial. J Am Coll Cardiol 1994;23:993-1003.
6. Ferguson JJ. Meeting highlights: American College of Cardiology 45th Annual Scientific Session, Orlando, Florida, March 24-27, 1996. Circulation 1996;94:1-5.
7. Antman EM, for the TIMI 9A Investigators. Hirudin in acute myocardial infarction: Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trial. Circulation 1994;90:1624-1630.
8. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994;90:1631-1637.
9. Metz B, Granger C, White H, Simes J, Topol E. Streptokinase and hirudin reduce death and reinfarction in acute myocardial infarction compared with streptokinase and heparin: Results from GUSTO-IIb. Circulation 1996;94:I-430.
10. Owen J, Friedman KD, Grossman BA, et al. Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity. Blood 1988;72:616-620.
11. Simes J, Granger C, Antman E, et al. Impact of hirudin versus heparin on mortality and (re)infarction in patients with acute coronary syndromes: a prospective meta-analysis of the GUSTO-IIb and TIMI 9b trials. Circulation 1996;94:I-430.
12. Loscalzp J. Thrombin inhibition in flbrianolysis. A Hobson's hcoice of alternatives. Circulation 1996;94:863-865.