In vitro antifungal activity of novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and comparison with fluconazole

Diagnostic Microbiology and Infectious Disease

Volumn 29, Issue 2, 1997, Pages 103-106

  Stevens, David A ^a,b,c   Aristizabal, Beatriz H ^b  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b CALIFORNIA INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,4 DIFLUOROPHENYL) 3 METHYL 2 (1H 1,2,4 TRIAZOL 1 YL) 4 [4 (TRIFLUOROMETHYL)BENZOYL]MORPHOLINE; 2 (2,4 DIFLUOROPHENYL) 6 HYDROXY 3 METHYL 2 (1H 1,2,4 TRIAZOL 1 YL) 4 [4 (TRIFLUOROMETHYL)BENZOYL]MORPHOLINE; FLUCONAZOLE; MORPHOLINE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS; CANDIDA; CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG STRUCTURE; FUNGICIDAL ACTIVITY; HISTOPLASMA CAPSULATUM; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; CULTURE MEDIA; FLUCONAZOLE; FUNGI; HUMANS; MICROBIAL SENSITIVITY TESTS; MORPHOLINES; MYCOSES; TRIAZOLES;

EID: 0030840210     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0732-8893(97)00104-1     Document Type: Article

References (6)

1. Bartroli J, Turmo E, Alguero M, Boncompte E, Vericat ML, Garcia-Rafenell J, Forn J (1995) Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring. J Med Chem 38:3918-3932.
2. Clemons KV, Stevens DA (1997) Efficacies of two novel azole derivatives each containing a morpholine ring, UR-9746 and UR-9751, against systemic murine coccidioidomycosis. Antimicrob Agents Chemother 41:200-203.
3. Fromtling RA, Galgiani JN, Pfaller MA, Espinel-Ingroff A, Bartlett KF, Body BS, Frey C, Hall G, Roberts GD, Nolte FB, Odds FC, Rinaldi M, Sugar AM, Villareal K (1993) Multicenter evaluation of a broth macrodilution antifungal susceptibility test for yeasts. Antimicrob Agents Chemother 37:39-45.
4. Hanson LH, Stevens DA (1992) Comparison of antifungal activity of amphotericin B deoxycholate suspension with that of amphotericin B cholesteryl sulfate colloidal dispersion. Antimicrob Agents Chemother 36:486-488.
5. Polak A (1992) Amorolfine, RO 14-4767/002, Loceryl. In: Recent Progress in Antifungal Chemotherapy. Eds, Yamaguchi H, Kobayashi GS, Takahashi H. New York: Marcel Dekker, pp. 125-134.
6. Stevens DA (1994) Current status and future directions of antifungal therapy. Infect Dis Clin Prac 3 (suppl 2):S97-S102.