Possible involvement of ATP-dependent K-channel related mechanisms in the antihypertensive and cough suppressant effects of the novel ACE inhibitor (2S, 3aS, 7aS)-1-(N2-nicotinoyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2- carboxylic acid;Mogliche Beteiligung von Mechanismen der ATP-abhangigen Kalium-Kanale and der antihypertensiven und antitussiven Wirkung des neuartigen ACE- Hemmers (2S, 3aS, 7aS)-1-(N2-Nicotinoyl-L-lysyl-γ-D-glutamyl)octahydro-1H- indol-2-carboxylsaure

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 6, 1997, Pages 726-730

  Nagata, Shinya ^a   Takeyama, Kunihiko ^a   Hosoki, Kanoo ^a   Karasawa, Tadahiko ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

(2S,3aS,7aS) 1 (N2 Nicotinoyl L lysyl D glutamyl)octahydro 1H indole 2 carboxylic acid; Angiotensin converting enzyme inhibitor; CAS 116662 73 8; DU 1777, antihypertensive and cough suppressant mechanisms

Indexed keywords

1 (N2 NICOTINOYLLYSYL GAMMA DEXTRO GLUTAMYL)OCTAHYDRO 1H INDOLE 2 CARBOXYLIC ACID; ADENOSINE TRIPHOSPHATE; ALACEPRIL; ANTIHYPERTENSIVE AGENT; ANTITUSSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; CAPTOPRIL; CITRIC ACID; CROMAKALIM; DEOXYCORTICOSTERONE ACETATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; GLIBENCLAMIDE; IMIDAPRIL; LISINOPRIL; NIFEDIPINE; POTASSIUM CHANNEL; QUINAPRIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; DRUG MECHANISM; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RENOVASCULAR HYPERTENSION; VASCULAR RING;

ADENOSINE TRIPHOSPHATE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTITUSSIVE AGENTS; AORTA, THORACIC; BENZOPYRANS; BLOOD PRESSURE; CROMAKALIM; DIPEPTIDES; GLYBURIDE; GUINEA PIGS; INDOLES; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNELS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR;

EID: 0030839286     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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