Clodronate prevents bone loss in aged ovariectomized rats

Calcified Tissue International

Volumn 61, Issue 2, 1997, Pages 151-157

  Kippo, K ^a   Hannuniemi, R ^a   Lauren L ^a   Peng, Z ^b   Isaksson, P ^a   Virtamo, T ^a   Osterman T ^a   Pasanen, I ^a   Sellman, R ^a   Vaananen H K ^b  

^a Oy Leiras Finland Ab   (Finland)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

Aged rat; Biomechanics; Clodronate; Histomorphometry; Osteopenia

Indexed keywords

CLODRONIC ACID;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE ATROPHY; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; LUMBAR VERTEBRA; NONHUMAN; OSTEOLYSIS; OSTEOPENIA; OVARIECTOMY; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

AGING; AMINO ACIDS; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DISEASES, METABOLIC; CLODRONIC ACID; EATING; ESTRADIOL; FEMALE; OSTEOCALCIN; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030839190     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002239900314     Document Type: Article

References (28)

1. Wronski TJ, Yen CF (1991) The ovariectomized rat model as an animal model for postmenopausal bone loss. Cells Mat (suppl)1:69-74
2. Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-192
3. Kalu DN, Liu CC, Hardin RR, Hollis BW (1989) The aged rat model of ovarian hormone deficiency bone loss. Endocrinology 124:7-16
4. Gaumet N, Seibel MJ, Braillon P, Giry J, Lebecque P, Davicco MJ, Coxam V, Rouffet J, Delmas PD, Barlet JP (1996) Influence of ovariectomy on bone metabolism in very old rats. Calcif Tissue Int 58:256-262
5. Sims NA, Morris HA, Moore RJ, Durbridge TC (1996) Increased bone resorption precedes increased bone formation in the ovariectomized rat. Calcif Tissue Int 59:121-127
6. Baumann BD, Wronski TJ (1995) Response of cortical bone to antiresorptive agents and parathyroid hormone in aged ovariectomized rats. Bone 16:247-253
7. 2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats. Bone 11:253-266
8. Li XJ, Jee WSS, Ke HZ, Mori S, Akamine T (1991) Age-related changes of cancellous and cortical bone histomorphometry in female Spraque-Dawley rats. Cells Mat (suppl)1: 25-35
9. Fleisch H (1991) Bisphosphonates. Pharmacology and use in the treatment of tumour-induced hypercalcaemic and metastatic bone disease. Drugs 42:919-944
10. Rodan GA, Fleisch HA (1996) Bisphosphonates: mechanisms of action. J Clin Invest 97:2692-2696
11. Selander K, Lehenkari P, Väänänen HK (1994) The effects of bisphosphonates on the resorption cycle of isolated osteoclasts. Calcif Tissue Int 55:368-375
12. Selander KS, Mönkkönen J, Karhukorpi EK, Härkönen PL, Hannuniemi R, Väänänen HK (1996) Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. Mol Pharmacol 450:1127-1138
13. Mühlbauer RC, Russell RGG, Williams DA, Fleisch H (1971) The effects of diphosphonates, polyphosphates, and calcitonin on "immobilization osteoporosis" in rats. Eur J Clin Invest 1:336-344
14. Lepola V, Jalovaara P, Väänänen K (1994) The influence of clodronate on the torsional strength of the growing rat tibia in immobilization osteoporosis. Bone 15:367-371
15. Kippo K, Hannuniemi R, Virtamo T, Laurén L, Ikävalko H, Kovanen V, Österman T, Sellman R (1995) The effects of clodronate on increased bone turnover and bone loss due to ovariectomy in rats. Bone 17:533-542
16. Lepola VT, Kippo K, Hannuniemi R, Laurén L, Virtamo T, Österman T, Jalovaara P, Sellman R, Väänänen HK (1996) Bisphosphonates clodronate and etidronate in the prevention of ovariectomy-induced osteopenia in growing rats. J Bone Miner Res 11:1508-1517
17. Schenk RK, Olah AJ, Herrmann W (1984) Preparation of calcified tissues for light microscopy. In: Dickson GR (ed) Methods of calcified tissue preparation. Elsevier, Amsterdam pp 1-56
18. Peng Z, Tuukkanen J, Zhang H, Jämsä T, Väänänen HK (1994) The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15:523-532
19. Lepola VT, Hannuniemi R, Kippo K, Laurén L, Jalovaara P, Väänänen HK (1996) Long-term effects of clodronate on growing rat bone. Bone 18:191-196
20. Parfitt AM, Mathews CHE, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. J Clin Invest 72:1396-1409
21. Foldes J, Shih M-S, Parfitt AM (1990) Frequency distribution of tetracycline-based measurements: implications for the interpretation of bone formation indices in the absence of double-labeled surfaces. J Bone Miner Res 5:1063-1067
22. Danielsen CC, Mosekilde Lis, Svenstrup B (1993) Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int 52:26-33
23. Crenshaw TD, Peo ER Jr, Lewis AJ, Moser BD (1981) Bone strength as a trait for assessing mineralization in swine. A critical review of techniques involved. J Anim Sci 53:827-835
24. Ferretti JL, Capozza RF, Mondelo N, Zanchetta JR (1993) Interrelationships between densitometric, geometric, and mechanical properties of rat femora: inferences concerning mechanical regulation of bone modeling. J Bone Miner Res 8: 1389-1396
25. SAS statistical software, version 6 manuals (1990) SAS Institute Inc, Cary, NC
26. Mosekilde LIS, Danielsen CC, Knudsen UB (1993) The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone 14:1-6
27. Evans RA, Howlett CR, Dunstan CR, Hills E (1982) The effect of long-term low-dose diphosphonate treatment on rat bone. Clin Orthop Rel Res 165:290-299
28. Chow JWM, Badve S, Chambers TJ (1993) A comparison of microanatomic basis for coupling between bone formation and bone resorption in man and the rat. Bone 14:355-360