Attempt at determining the relationship between pharmacokinetic fluctuation and the extrapyramidal effect in selected neuroleptics

Homeostasis in Health and Disease

Volumn 38, Issue 2, 1997, Pages 58-60

  Grossmann, V ^a,c   Kvetina J ^a   Pastera, J ^a   Perlik, J ^b   Svoboda, D ^a   Svoboda, Z ^a  

^a INSTITUTE OF MATHEMATICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Inst of Experim Biopharmaceut AS   (Czech Republic)

Author keywords

Extrapyramidal side effect; Fluctuation index; Neuroleptics

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; PIMOZIDE; SULPIRIDE; TRIFLUOPERAZINE;

ARTICLE; CORRELATION FUNCTION; DRUG BLOOD LEVEL; DRUG EFFECT; EXTRAPYRAMIDAL SYMPTOM;

EID: 0030839101     PISSN: 09607560     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ackenheil M: Clozapin. Psychopharmacology 99, 32-37 (1989)
2. Balant Georgia AE, Balant L: Antipsychotic drugs: Clinical pharmacokinetics of potential candidates for plasma concentration monitoring. Clinical pharmacokinetics 13, 2, 65-90 (1987)
3. Caccia S, Garattini S: Formation of active metabolites of psychotropic drugs. Un update rewiew of their significance Clin Pharmacokinetics 18, 6, 434-459 (1990)
4. Froeming JS, Lam YWF, Jann MW, Davis CM: Pharmacokinetics of haloperidol. Clin Pharmacokinetics 17, 6, 396-423 (1989)
5. Dahl SG, Strandjors RE: Pharmacokinetics of chlorpromazine after single and chronic dosage. Clin. Pharmacology and Therapeutics 21, 437-438 (1977)
6. Baldesarini RJ, Frankenburg FR: Clozapine: A novel antipsychotic agent. N Engl J Med 324, 746-754 (1991)
7. Furlanut M, Benetello P, Baraldo M, Zara G, Montonari G, Donzelli F: Clorpromazine disposition in relation to age in children. Clin Pharmacokinetics 18, 4, 329-331 (1990)
8. Janků I et col: Farmakokinetické základy dávkováni léků. Avicenum Praha 57-67 (1986) Martindale - The Extrapharmacopoeia III. ed. JSF Reynolds Pharmaceutical press London 574 (1993)
9. Me Creadie RG, Heykants HP, Chalmers A, Anderson AM: Plasma pimozide profiles in chronic schizophrenics. Br J of Clin Pharmacology 7, 533-534 (1979)
10. Midha KK, Me Kay G: Kinetics of oral trifluperazine disposition in man. Br J Clin Pharmacol 3, 15, 380-382 (1983)
11. Svoboda Z, Pastera J, Květina J: Comparative pharmacokinetic study of sulpiride in experimental minipigs and human volunteers. MEFA abstracts Brno 233 (1995)
12. Weber E: Grundriss der biologischen Statistik IV. auflage VEB Gustav Fisher Jena 269-281 (1961)