Extradural bupivacaine-loaded microspheres and spinal cord blood flow in the chronically instrumented rabbit

Clinical Physiology

Volumn 17, Issue 4, 1997, Pages 361-370

  Malinovsky, J M ^a   Bernard, J M ^a   Le Corre, P ^b   Faivre, A ^a   Chatal, J F ^c   Pinaud, M ^a  

^a HÔTEL DIEU   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c CENTRE RENÉ GAUDUCHEAU   (France)

Author keywords

Blood flow; Bupivacaine; Controlled release; Extradural anaesthetic techniques; Local anaesthetics; Poly (D,L lactic acid) microspheres; Polymer; Spinal anaesthetic techniques; Spinal cord

Indexed keywords

BUPIVACAINE; MICROSPHERE; POLYLACTIC ACID;

ANALGESIA; ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; EPIDURAL DRUG ADMINISTRATION; HEART OUTPUT; INTRASPINAL DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; NERVE BLOCK; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD; SPINAL CORD BLOOD FLOW; SUSTAINED RELEASE FORMULATION;

EID: 0030837824     PISSN: 01445979     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2281.1997.04040.x     Document Type: Article

References (23)

1. BRUMAGE P. R., JOYAL A. C. & BINNEY J. C. (1963) Local anaesthetic drugs: penetration from the spinal extradural space into the neuraxis. Science, 140, 392-394.
2. BUCKBERG G. D., LUCK J. C., PAYNE B., HOFFMAN J. I. E., ARCHIE J. P. & FIXLER D. E. (1971) Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol, 31, 598-604.
3. BYERS M. G., FINK B. R., KENNEDY R. D., MIDDAUGH M. E. & HENDRICKSON A. E (1973) Effects of lidocaine on axonal morphology: microtubules, and rapid transport in rabbit vagus nerve in vitro. J Neurobiol, 4, 125-143.
4. CHAVKO M., KALINCAKOVA K., KLUCHOVA D. & NEMOTO E. (1991) Blood flow and electrolytes in spinal cord ischemia Exp Neurol, 112, 299-303.
5. CROSBY G. (1985) Local spinal cord blood flow and glucose utilization during spinal anesthesia with bupivacaine in conscious rats. Anesthesiology, 63, 55-60.
6. DEMEURE DLATTE D., BERNARD J.M., BLANLŒIL Y. , PELTIER P., FRANÇOIS T. & CHATAL J. F. (1995) Induction of anaesthesia by propofol and hepatic blood flow in the rabbit. Clin Physiol, 15, 515-522.
7. HICKEY R., ALBIN M. S., BUNEGIN L. & GELINEAU J. (1986) Autoregulation of spinal cord blood flow: is the cord a microcosm of the brain? Stroke, 17, 1183-1189.
8. HOGAN Q. H., STEKIEL T. A., STADNICKA A., BOSJNAK Z. J. & KAMPINE J. P. (1995) Region of epidural blockade determines sympathetic and mesenteric capacitance effects in rabbits. Anesthesiology, 83, 604-610.
9. JOHNSON S. H. KRAIMER J. M. & GRAEBER G. M. (1993) Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in rabbits. Stroke, 24, 1547-1553.
10. KOZODY R., ONG, B., PALAHNIUK R. J., WADE J. G., CUMMING M. O. & PUCCI W. R. (1985a) Subarachnoid bupivacaine decreases spinal cord blood flow in dogs. Can Anaesth J Soc, 32, 216-222.
11. KOZODY R., SCHWARTZ J., PALAHNIUK R. J., BIEHL D. R. & WADE J.G. (1985b) Spinal cord blood flow following subarachnoid lidocaine. Can Anaesth J Soc. 32, 472-478.
12. LE CORRE P., LE GUEVELLO P., GAJAN V., CHEVANNE F. & LE VERGH R. (1994) Preparation and characterization of bupivacaine-loaded polyactide and polyactide-co-glycolide microspheres. Int J Pharm. 107, 41-49.
13. LE GUEVELLO P., LE CORRE P., CHEVANNE F. & LE VERGE R. (1993) High-performance liquid chromatogaphic determination of bupivacaine in plasma samples for biopharmaceutical studies and application to seven other local anesthetics. J Chromatogr. 622, 284-290.
14. LI D. F., BAHAR M., COLE G. & ROSEN M. (1985) Neurological toxicity of the subarachnoid infusion of bupivacaine. lignocaine or 2-chloroprocaine in the rat. Br J Anaesth, 57, 424-129.
15. LINDSBERG G P. J., OONEILI, J. T., PAAKKARI I. A., HALLENBECK J. M. & FEUERSTFIN G. (1989) Validation of laser-Doppler flowmetry in measurement of spinal cord blood flow. Am J Physiol, 257, 674-680.
16. MALINOVSKY J. M., BERNARD J. M., BAUDRIMONT M., DUMAND J. B. & LEPAGE J. Y. (1997) A chronic model for experimental investigation of epidural anaesthesia in the rabbit. Reg Anesth 22, 80-85.
17. MARCUS M. L., HEISTAD D. D., EHRHARDT J. C. & ABBOUD F. (1976) Total and regional cerebral blood flow measurement with 7-10, 15-, 25-, and 50-μm microspheres. J Appl Physiol. 40, 501-507.
18. MARCUS M. L., HEISTAD D. D., EHRHARDT J. C. & ABBOUD F. (1977) Regulation of total and regional spinal cord blood flow. Circ Res. 41, 128-134.
19. MITCHELI, P., GOAD R., ERWIN C. W., CAMPORESI E. M., MOON R. E., WATKINS W. D. & BENNETT P. B. (1989) Effect of epidural lidocaine on spinal cord blood flow. Anesth Analg. 68, 312-317.
20. NEUTZE J. M., WYLER F. & RUDOLPH A. M. (1968) Use of radioactive microspheres to assess distribution of carbide output in rabbits. Am J Physiol. 215, 486-495.
21. NYSTRÖM B., STJERNSCHANTZ J. & SMEOEGARD G. (1984) Regional spinal cord blood flow in the rabbil, cat and monkey. Acta Neurol Scand. 70, 307-313.
22. OSENBACH R. K., HITCHON P. W., MOUW L. & YAMADA T. (1993) Effects of spinal cord ischemia on evoked potential recovery and postischemic regional spinal cord blood flow. J Spinal Disord, 6, 146-154.
23. TUCKER G. T. & MATHER L. E. (1987) Properties, absorption, and disposition of local anesthetic agents. In: Neural Blockade in Clinical Anesthesia and Management of Pain, 2nd edn (eds Cousins M. J. & Bridenbaugh P. O.), pp. 57-110. J.B. Lippincott, Philadelphia.