Measurement of NO synthesis in humans by L-[15N2]arginine: Application to the response to vaccination

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Macallan, Derek C ^a   Smith, Lorna M ^b   Ferber, Jean ^c   Milne, Eric ^d   Griffin, George E ^a   Benjamin, Nigel ^b   McNurlan, Margaret A ^c  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c ROWETT RESEARCH INSTITUTE   (United Kingdom)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

Acute phase response; Inflammation; Nitrate

Indexed keywords

ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ACUTE PHASE RESPONSE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; MALE; MASS SPECTROMETRY; NITROGEN METABOLISM; PRIORITY JOURNAL; VACCINATION;

EID: 0030837006     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.6.r1888     Document Type: Article

References (20)

1. 15N analysis. Soil Sci. Soc. Am. Proc. 53: 1707-1711, 1989.
2. Castillo, L., A. M. Ajami, S. Branch, T. E. Chapman, Y. M. Yu, J. F. Burke, and V. R. Young. Plasma arginine kinetics in adult man: response to an arginine-free diet. Metabolism 43: 114-122, 1994.
3. Castillo, L., T. E. Chapman, M. Sanchez, Y. M. Yu, J. F. Burke, A. M. Ajami, J. Vogt, and V. R. Young. Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Proc. Natl. Acad. Sci. USA 90: 7749-7753, 1993.
4. Castillo, L., T. C. DeRojas, T. E. Chapman, J. Vogt, J. F. Burke, S. R. Tannenbaum, and V. R. Young. Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man. Proc. Natl. Acad. Sci. USA 90: 193-197, 1993.
5. Castillo, L., M. Sanchez, J. Vogt, T. E. Chapman, T. C. DeRojas-Walker, S. R. Tannenbaum, A. M. Ajami, and V. R. Young. Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E360-E367, 1995.
6. Cooper, A. L., M. A. Horan, R. A. Little, and N. J. Rothwell. Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade. J. Appl. Physiol. 72: 2322-2328, 1992.
7. Dykhuizen, R. S., M. Copland, C. C. Smith, G. Douglas, and N. Benjamin. Plasma nitrate concentration and urinary nitrate excretion in patients with gastroenteritis. J. Infect. Dis. 31: 73-75, 1995.
8. Elia, M. Body composition analysis: an evaluation of 2 component models, multicomponent models and bedside techniques. Clin. Nutr. 11: 114-127, 1992.
9. Farrell, A. J., D. R. Blake, R. M. Palmer, and S. Moncada. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann. Rheum. Dis. 51: 1219-1222, 1992.
10. Garlick, P. J., M. A. McNurlan, E. B. Fern, A. M. Tomkins, and J. C. Waterlow. Stimulation of protein synthesis and breakdown by vaccination. Br. Med. J. 281: 263-265, 1980.
11. Gomez-Jimenez, J., A. Salgado, M. Mourelle, M. C. Martin, R. M. Segura, R. Peracaula, and S. Moncada. L-Arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit. Care Med. 23: 253-258, 1995.
12. 15N]nitrate in biological fluids. Anal. Biochem. 126: 131-138, 1982.
13. Jungersten, L., A. Edlund, L. O. Hafstrom, L. Karlsson, A. S. Petersson, and A. Wennmalm. Plasma nitrate as an index of immune system activation in animals and man. J. Clin. Lab. Immunol. 40: 1-4, 1993.
14. Moncada, S. The 1991 Ulf von Euler lecture. The L-arginine: nitric oxide pathway. Acta Physiol. Scand. 145: 201-227, 1992.
15. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012, 1993.
16. Moshage, H., B. Kok, J. R. Huizenga, and P. L. Jansen. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin. Chem. 41: 892-896, 1995.
17. Ochoa, J. B., A. O. Udekwu, T. R. Billiar, R. D. Curran, F. B. Cerra, R. L. Simmons, and A. B. Peitzman. Nitrogen oxide levels in patients after trauma and during sepsis. Ann. Surg. 214: 621-626, 1991.
18. Rhodes, P. M., A. M. Leone, P. L. Francis, A. D. Struthers, and S. Moncada. The L-arginine:nitric oxide pathway is the major source of plasma nitrite in fasted humans. Biochem. Biophys. Res. Commun. 209: 590-596, 1995.
19. Schofield, W. N. Predicting basal metabolic rate, new standards and review of previous work. Hum. Nutr. Clin. Nutr. 39C, Suppl. 1: 5-41, 1985.
20. Stichtenoth, D. O., J. Fauler, H. Zeidler, and J. C. Frolich. Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone. Ann. Rheum. Dis. 54: 820-824, 1995.