Flumazenil blockade of anxiety following ethanol withdrawal in rats

Psychopharmacology

Volumn 131, Issue 4, 1997, Pages 354-360

  Moy, S S ^a   Knapp, D J ^a   Criswell, H E ^a   Breese, G R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Benzodiazepines; Corticotropin releasing factor; Elevated plus maze; Stress

Indexed keywords

ALCOHOL; ANXIOLYTIC AGENT; BENZODIAZEPINE; CHLORDIAZEPOXIDE; CORTICOTROPIN RELEASING FACTOR; FLUMAZENIL; NEUROPEPTIDE; SODIUM CHLORIDE; ZOLPIDEM;

ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BENZODIAZEPINES; CORTICOTROPIN-RELEASING HORMONE; ETHANOL; FLUMAZENIL; GABA MODULATORS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRESS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030836057     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050303     Document Type: Article

References (40)

1. Adinoff B, Majchrowicz E, Martin PR, Linnoila M (1986) The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome. Biol Psychiatry 21:643-649
2. Alho H, Miyata M, Korpi E, Kiianmaa K, Guidotti A (1987) Studies of a brain polypeptide functioning as a putative endogenous ligand to benzodiazepine recognition sites in rats selectively bred for alcohol related behavior. Alcohol Alcohol Suppl I:637-641
3. Auta J, Romeo E, Kozikowski A, Ma D, Costa E, Guidotti A (1993) Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict. antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. J Pharmacol Exp Ther 265 [2]:649-656
4. Baldwin HA, File SE (1988) Reversal of increased anxiety during benzodiazepine withdrawal: evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor. Brain Res Bull 20: 603-606
5. Baldwin HA, Rassnick S, Rivier J, Koob GF, Britton KT (1991) CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat. Psychopharmacology 103:227-232
6. Bonetti EP, Pieri L, Cumin R, Schaffner R, Martin JR (1981) Preclinical research findings with flumazenil (Ro 15-1788, Anexate™): behavioural studies. Eur J Anaesthesiol Suppl 2: 54-62
7. Bonetti EP, Pieri L, Cumin R, Schaffner R, Pieri M, Gamzu ER, Muller RKM, Haefely W (1982) Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects. Psychopharmacology 78:8 18
8. Areceptors. Neuropharmacology 30 [12B]:1387-1389
9. Britton KT, Lee G, Koob GF (1988) Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test. Psychopharmacology 94:306-311
10. Chan AWK, Leong FW, Schanley DL, Langan MC, Penetrante F (1991) Flumazenil (Ro15-1788) does not affect ethanol tolerance and dependence. Pharmacol Biochem Behav 39: 659-663
11. Corda MG, Ferrari M, Guidotti A, Konkel D, Costa E (1984) Isolation, purification and partial sequence of a neuropeptide (diazepam-binding inhibitor) precursor of an anxiogenic putative ligand for benzodiazepine recognition site. Neurosci Lett 47:319-324
12. Criswell HE, Breese GR (1993) Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment. Br J Pharmacol 110:753 761
13. Dunn AJ, Berridge CW (1990) Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev 15:71-100
14. Dunn AJ, File SE (1987) Corticotropin-releasing factor has an anxiogenic action in the social interaction test. Hormones Behav 21:193-202
15. Escorihuela RM, Fernandez-Teruel A, Nunez FJ, Zapata A, Tobena A (1992) Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior. Psychopharmacology 106:282-284
16. Ferrarese C, Mennini T, Pecora N, Gobbi M, Appollonio I, Bernasconi P, Frigo M, Regondi C, Pierpaoli C, Frattola L, Garattini S (1991a) Acute noise stress in rats increases the levels of diazepam binding inhibitor (DBI) in hippocampus and adrenal gland. Psychopharmacology 103:339-342
17. Ferrarese C, Mennini T, Pecora N, Pierpaoli C, Frigo M, Marzorati C, Gobbi M, Bizzi A, Codegoni A, Garattini S, Frattola L (1991b) Diazepam binding inhibitor (DBI) increases after acute stress in rat. Neuropharmacology 30 [12B]:1445-1452
18. File SE, Hitchcott PK (1990) A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena. Psychopharmacology 101:525-532
19. File SE, Pellow S (1986) Intrinsic actions of benzodiazepine receptor antagonist Ro 15-1788. Psychopharmacology 88: 1-11
20. File SE, Baldwin HA, Aranko K (1987) Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance. Brain Res Bull 19:607 610
21. File SE, Baldwin HA, Hitchcott PK (1989) Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the rat. Psychopharmacology 98:262 264
22. File SE, Zharkovsky A, Hitchcott PK (1992) Effects of nitrendipine. chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 16:87 93
23. Frye GD, Chapin RE, Vogel RA, Mailman RB, Kilts CD, Mueller RA, Breese GR (1981) Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: a comparison with ethanol. J Pharmacol Exp Ther 216:306-314
24. Guidotti A, Forchetti CM, Corda MG, Konkel D, Bennett CD, Costa E (1983) Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proc Natl Acad Sci USA 80:3531-3535
25. Kapczinski F, Curran HV, Gray J, Lader M (1994) Flumazenil has an anxiolytic effect in simulated stress. Psychopharmacology 114:187 189
26. Katsura M, Ohkuma S, Tsujimura A, Kuriyama K (1995) Increase of diazepam binding inhibitor mRNA levels in the brains of chronically ethanol-treated and -withdrawn mice. J Pharmacol Exp Ther 273:1529-1533
27. Lee C, Rodgers RJ (1991) Effects of benzodiazepine receptor antagonist, flumazenil, on antinociceptive and behavioural responses to the elevated plus-maze in mice. Neuropharmacology 30 [12A]:1263-1267
28. Lister RG (1987) The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 92: 180-185
29. Little HJ (1991) The benzodiazepines: anxiolytic and withdrawal effects. Neuropeptides 19 [Suppl]:11 14
30. Maier SF, Grahn RE, Maswood S, Watkins LR (1995) The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock. Psychopharmacology 121:250 258
31. Miyata M, Mocchetti I, Ferrarese C, Guidotti A, Costa E (1987) Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/β-carboline recognition site. Proc Natl Acad Sci USA 84:1444-1448
32. Moy SS, Knapp DJ, Criswell HE, McCown TJ, Breese GR (1993) Effects of corticotropin-releasing factor and flumazenil on two measures of anxiety. Soc Neurosci Abstr 19 [1]:1
33. Nutt DJ, Cowen PJ, Little HJ (1982) Unusual interactions of benzodiazepine receptor antagonists. Nature 295:436-438
34. Pellow S, File SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24:525-529
35. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Meth 14: 149 167
36. Pole P, Laurent J-P, Scherschlicht R, Haefely W (1981) Electrophysiological studies on the specific benzodiazepine antagonist Ro 15 1788. Naunyn-Schmiedeberg's Arch Pharmacol 316:317-325
37. Rassnick S, Heinrichs SC, Britton KT, Koob GF (1993) Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res 605:25-32
38. Roy A (1991) Cerebrospinal fluid diazepam binding inhibitor in depressed patients and normal controls. Neuropharmacology 30 [12B]:1441-1444
39. Sarnyai Z, Biro E, Gardi J, Vecsernyes M, Julesz J, Telegdy G (1995) Brain corticotropin-releasing factor mediates "anxiety-like" behavior induced by cocaine withdrawal in rats. Brain Res 675:89-97
40. Treit D, Menard J, Royan C (1993) Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 44:463 469