A mutation in the MSH5 gene results in alkylation tolerance

Cancer Research

Volumn 57, Issue 13, 1997, Pages 2715-2720

  Bawa, Sonya ^a   Xiao, Wei ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; METHYLNITRONITROSOGUANIDINE; METHYLTRANSFERASE;

ALKYLATION; ARTICLE; BASE MISPAIRING; CHEMICAL CARCINOGENESIS; CHROMOSOME DELETION; CONTROLLED STUDY; DNA METHYLATION; GENE MUTATION; GLUTATHIONE METABOLISM; MUTATION RATE; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ALKYLATION; DNA REPAIR; DNA-BINDING PROTEINS; DRUG TOLERANCE; FUNGAL PROTEINS; METHYLNITRONITROSOGUANIDINE; METHYLTRANSFERASES; MUTATION; SACCHAROMYCES CEREVISIAE PROTEINS; YEASTS;

EID: 0030835346     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. 6-methylguanine built into a unique site in a viral genome. Proc. Natl. Acad. Sci. USA, 81: 6271-6275, 1984
2. 4-melhylthymine in vivo determined by an enzymatic approach Hi site-specific mutagenesis. Proc. Natl. Acad. Sci. USA, 83: 8501-8505, 1986.
3. 6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: a review. J. Cell Sci., 6 (Suppl.): 333-335, 1987.
4. 6-methylguanine DNA repair methyltransferase. J. Bacteriol., 173: 2068-2076, 1991.
5. 4-melhylthymine DNA repair methyltransferase gene. EMBO J., 10: 2179-2186, 1991.
6. Kat, A., Thilly, W. G., Fang, W., Longley, M. J., Li. G., and Modrich, P. An alkylation tolerant, mutator human cell line is deficient in strand specific mismatch repair. Proc. Natl. Acad. Sci. USA, 90: 6424-6428, 1993.
7. Branch, P., Aquilina, G., Bignami, M., and Karran, P. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature (Lond.), 362: 652-654, 1993.
8. Goldmacher, V. S., Cuzick, R. A., Jr., and Thilly, W. G. Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidinc. J. Biol. Chem., 261: 12462-12471, 1986.
9. Fisher, R., Lescoe, M. R., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, G., Kane, M., and Kolodner, R. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75: 1027-1038, 1993.
10. Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parson, R., Peltomaki, P., Sistonen, P., Aaloten, L. A., Nystromlahiti, M., Guan, X-Y., Zhang, J., Meltzer, P. S., Yu, J-W., Kao, F-T., Chen, D. J., Cerosaletti, K. M., Fournier, R. E. K., Todd, S., Lewis, T., Leach, R. J., Naylor, S. L., Weissenbach, J., Mecklin, J-P., Jarvinen, H., Peterson, G. M., Hamilton, S. R., Green, J., Jass, J., Watson, P., Lynch, H. T., Trent, J. M., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutations of a mutS homolog in hereditary nonpolyposis colon cancer. Cell, 75: 1215-1225, 1993.
11. Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Leseoe, M. K., Kane, M., Earabino, C. Lipford, J., Lindblom, A., Tannergard, P., Bollag, R. J., Godwin, A. R., Ward, D. C., Nordenskjold, M., Fishel, R., Kolodner, R., and Liskay, R. M. Mutation in the DNA mismatch repair gene homologue gMLH1 is associated with hereditary non-polyposis colon cancer. Nature (Lond), 368: 258-261, 1994.
12. Papadopoulos, N., Nieolaides, N. C., Wei, Y-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Hamilton, S. R., Peterson, G. M., Watson, P., Lynch, H. T., Peltomaki, P., Mecklin, J-P., de la Chapelle, A., Kinzler, K. W., and Vogelstein, B. Mutation of a mutL homolog in hereditary colon cancer. Science (Washington DC), 263: 1625-1629, 1994.
13. Nicolaides, N. C., Papadopoulos, N., Liu, B., Wei, Y., Carter, K. C., Ruhen, S. M., Rosen, C. A., Haselline, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J. C., Dunlop, M. G., Hamilton, S. R., Peterson, G. R., de la Chapelle, A., Vogelstein, B., and Kinzler, K. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond.), 371: 75-80, 1994.
14. Kolodner, R. Mismatch repair: mechanisms and relationship to cancer susceptibility. Trends Biochem. Sci., 20: 397-401, 1995.
15. Kolodner, R. Biochemistry and genetics of eukaryole mismatch repair. Genes Dev., 10: 1433-1442, 1996.
16. Reenan, R. A. G., and Kolodner, R. D. Characterization of insertion mutations in Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions. Genetics, 132: 975-985, 1992.
17. Prolla, T. A., Christie, D-M., and Liskay, R. M. Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. Mol. Cell. Biol., 14: 407-415, 1994.
18. Strand, M. Prolla, T. A., Liskay, R. M., and Petes, T. D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (Lond.), 365: 274-276, 1993.
19. Marsischky, G. T., Filosi, N., Kane, M. F., and Kolodner, R. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev., 10: 407-420, 1996.
20. Johnson, R. E., Kovvali, G. K., Prakash, L., and Prakash, S. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J. Biol. Chem., 271: 7285-7288, 1996.
21. Ross-Macdonald, P., and Roeder, S. Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. Cell, 79: 1069-1080, 1994.
22. Hollingsworth, N. M., Ponte, L., and Halsey, C. MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev., 9: 1728-1739, 1995.
23. 6-methylguanine DNA methyltransferase-deficient yeast cells. Carcinogenesis (Lond.), 16: 1933-1939, 1995.
24. 6-methyguanine. J. Bacteriol., 177: 1511-1519, 1995.
25. Reenan, R. A. G., and Kolodner, R. D. Isolation and characterization of two Succharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins. Genetics, 132: 963-973, 1992.
26. Kramer, W., Kramer, B., Williamson, M. S., and Fogel, S. Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB. J. Bacteriol., 171: 5339-5346, 1989.
27. New, L., Liu, K., and Crouse, G. F. The yeast gene MSH3 defines a new class of eukaryotic MutS homologues. Mol. Gen. Genet., 239: 97-108, 1993.
28. Gietz, R. D., and Sugino, A. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene (Amst.), 74: 527-534, 1988.
29. Alani, E., Cao, L., and Kleckner, N. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics, 116: 541-545, 1987.
30. Boeke, J. D., LaCroute, F., and Fink, G. R. A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet., 197: 345-346, 1984.
31. Sherman, F., Fink, G. R., and Hicks, E. B. Methods in Yeast Genetics: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1983.
32. 6-methylguanine DNA repair methyltransferase in the yeast Saccharaomyces cerevisiae. J. Biol. Chem., 265: 20-25, 1990.
33. Hissin, P. J., and Hinf, R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem., 74: 214-226, 1976.
34. Drummond, J. T., Li, G-M., Longley, M. J., and Modrich, P. Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (Washington DC), 268: 1909-1912, 1995.
35. Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J. J., and Jiricny, J. GTBP, a 160 kD protein essential for mismatch binding activity in human cells. Science (Washington DC), 268: 1912-1914, 1995.
36. 4-methylthymine, or the cisplatin-d(GpG) adducts. Proc. Natl. Acad. Sci. USA, 93: 6443-6447, 1996.
37. Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R. E., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Wilson, J. K. V., Kinzler, K. W., Jiricny, J., and Vogelstein, B. Mutations of GTBP in genetically unstable cells. Science (Washington DC), 268: 1915-1917, 1995.
38. Lawley, P. D., and Thatcher, C. J. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. Biochem. J., 116: 693-707, 1970.
39. Day, R. S., III, Ziolkowski, C. H. J., Scudiero, D. A., Meyer, S. A., Lubiniecki, A. S., Girardi, A. J., Galloway, S. M, and Bynum, G. D. Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains. Nature (Lond.), 288: 724-727, 1980.
40. Xiao, W., and Samson, L. In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl. Acad. Sci. USA, 90: 2117-2121, 1993.
41. 6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cell lines from spontaneous G:C to A:T transitions. Cancer Res., 52: 6471-6475, 1992.
42. 6-methylguanine-DNA-methyltransferase in malignant human glioma cell lines. Carcinogenesis (Lond.), 12: 1739-1744, 1991.
43. - human cells. Cancer Res., 52: 5257-5263, 1992.
44. Koi, M., Umar, A., Chauhan, D. P., Cherian, S. P., Carethers, J. M., Kunkel, T. A., and Boland, C. R. Human chromosome 3 corrects mismatch repair deficiency and microsatellile instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res., 54: 4308-4312, 1994.
45. de Wind, N., Dekker, M., Berns, A., Radman, M., and te Riele, H. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell, 82: 321-330, 1995.
46. Aquilina, G., Hess, P., Fiumicino, S., Ceccotti, S., and Bignami, M. A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage. Cancer Res., 55: 2569-2575, 1995.
47. Liu, L., Markowitz, S., and Gerson, S. L. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl-nitrosourea). Cancer Res., 56: 5375-5379, 1996.
48. Aebi, S., Kurdi-Haidar, B., Gordon, R., Cenni, B., Zheng, H., Fink, D., Christen, R. D., Boland, C. R., Koi, M., Fishel, R., and Howell, S. B. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res., 56: 3087-3090, 1996.
49. Fink, D., Nebel, S., Aebi, S., Zheng, H., Cenni, B., Nehme, A., Christen, R. D., and Howell, S. B. The role of DNA mismatch repair in platinum drug resistance. Cancer Res., 56: 4881-4886, 1996.
50. Baker, S. M., Bronner, C. E., Zhang, L., Plug, A. W., Robatzek, M., Warren, G., Elliott, E. A., Yu, J., Ashley, T., Arnheim, N., Flavell, R. A., and Liskay, R. M. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 82: 309-319, 1995.
51. Baker, S. M., Plug, A. M., Prolla, T. A., Bronner, C. E., Harris, A. C., Yao, X., Christie, D. M., Monell, C., Arnheim, N., Bradley, A., Ashley, T., and Liskay, M. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat. Genet., 13: 336-342, 1996.
52. Edelman, W., Cohen, P. E., Kane, M., Lau, K., Morrow, B., Bennett, S., Umar, A., Kunkel, T., Cattoretti, G., Chaganti, R., Pollard, J. W., Kolodner, R., and Kucherlapati, R. Meiotic pachytene arrest in MLH1 deficient mice. Cell, 85: 1125-1134, 1996.
53. Liu, B., Parsons, R., Papadopoulos, N., Nicolaides, N. C., Lynch, H. T., Watson, P., Jass, J. R., Dunlop, M., Wyllie, A. Peltomaki, P., de la Chapelle, A., Hamilton, S. R., Vogelstein, R., and Kinzler, K. W. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat. Med., 2: 169-174.
54. Xiao, W., and Samson, L. The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions. Nucleic Acids Res., 20: 3599-3606, 1992.
55. Williamson, M. S., Game, J. C., and Fogel, S. Meiotic gene conversion mutants in Saccharomyces cerevisiae: Isolation and characterization of pms1-1 and pms1-2. Genetics, 110: 609-646, 1985.