Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae

Antimicrobial Agents and Chemotherapy

Volumn 41, Issue 12, 1997, Pages 2719-2723

  Clancy, Joanna ^a,b   Dib Hajj, Fadia ^a   Petitpas, Joan W ^a   Yuan, Wei ^a  

^a PFIZER INC   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; JOSAMYCIN; KANAMYCIN; LINCOMYCIN; MACROLIDE; NORFLOXACIN; OLEANDOMYCIN; ROXITHROMYCIN; SPIRAMYCIN; TYLOSIN;

ANTIBIOTIC RESISTANCE; ARTICLE; GENE DELETION; GENE ISOLATION; INCUBATION TIME; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STREPTOCOCCUS AGALACTIAE;

EID: 0030834464     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.12.2719     Document Type: Article

References (24)

1. Adams, A., and M. Oishi. 1972. General properties of arsenate-sensitive mutants of Bacillus subtilis. Mol. Gen. Genet. 118:295-299.
2. Arthur, M., A. Andremont, and P. Courvalin. 1987. Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin. Antimicrob. Agents Chemother. 31:404-409.
3. Arthur, M., C. Molinas, C. Mabilat, and P. Courvalin. 1990. Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob. Agents Chemother. 34:2024-2026.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl. 1989. Current protocols in molecular biology. John Wiley and Sons, New York, N.Y.
5. Barbero, J. L., J. M. Buesa, G. G. de Buitrago, E. Mendez, A. Perez-Aranda, and J. L. Garcia. 1986. Complete nucleotide sequence of the penicillin acylase gene from Kluyvera citrophila. Gene 49:69-80.
6. Broekaert, W., H.-I. Lee, A. Kush, N.-H. Chua, and N. V. Raikhel. 1990. Wound-induced accumulation of mRNA containing hevein sequence in laticifers of rubber tree (Hevea brasiliensis). Proc. Natl. Acad. Sci. USA 87:7633-7637.
7. Chernik, T., S. Bresler, V. Machkovskii, and D. Perumov. 1978. Riboflavin-biosynthesis operon in Bacillus subtilis. XVI. Localization of group ribC markers on the chromosome. Genetika 15:1569-1577.
8. Clancy, J., J. Sutcliffe, and A. Tait-Kamradt (Pfizer Central Research). 1997. Personal communication.
9. Clancy, J., J. Petitpas, F. Dib-Hajj, W. Yuan, M. Cronan, A. V. Kamath, J. Bergeron, and J. A. Retsema. 1996. Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes. Mol. Microbiol. 22:867-879.
10. Engelman, D. M., T. A. Steitz, and A. Goldman. 1986. Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu. Rev. Biophys. Chem. 15:321-353.
11. Hagman, K. E., W. P. Pan, B. G. Spratt, J. T. Balthazar, R. C. Judd, and W. M. Shafer. 1995. Resistance of Neisseria gonorrhoeae to antimicrobial agents is modulated by the mtrRCDE efflux system. Microbiology (Reading) 141:611-622.
12. Hanahan, D. 1983. Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol. 166:557-580.
13. Leclercq, R., and P. Courvalin. 1991. Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria. Antimicrob. Agents Chemother. 35:1273-1276.
14. Lewis, K. 1994. Multidrug resistance pumps in bacteria: variations on a theme. Trends Biochem. Sci. 19:119-123.
15. National Committee for Clinical Laboratory Standards. 1995. Suggested groupings of U.S. FDA-approved antimicrobial agents that should be considered for routine testing and reporting on fastidious organisms by clinical microbiology laboratories, p. 1. In J. H. Jorgensen, W. A. Craig, G. V. Doern, M. J. Ferraro, S. M. Finegold, J. Fung-Tomc, S. L. Hansen, J. Hindler, D. A. Preston, L. B. Reller, J. M. Swenson, F. C. Tenover, M. A. Wikler, and W. R. Wilson (ed.), Performance standards for antimicrobial susceptibility testing, vol. 15, no. 14. National Committee for Clinical Laboratory Standards, Wayne, Pa.
16. Nikaido, H. 1994. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264:382-388.
17. Omura, S., and H. Tanaka. 1984. Production and antimicrobial activity of macrolides, p. 3-29. In S. Omura (ed.), Macrolide antibiotics. Academic Press, London, United Kingdom.
18. Pan, W., and B. G. Spratt. 1994. Regulation of the permeability of the gonococcal envelope by the mtr system. Mol. Microbiol. 11:769-775.
19. Ross, J. I., E. A. Eady, J. H. Cove, W. J. Cunliffe, S. Baumberg, and J. C. Wootton. 1990. Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family. Mol. Microbiol. 4:1207-1214.
20. Rubens, C. (University of Washington School of Medicine). 1996. Personal communication.
21. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
22. Vaara, M., and T. Vaara. 1983. Sensitization of gram-negative bacteria to antibiotics and complement by a non-toxic oligopeptide. Nature 303:526-528.
23. Weisblum, B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39:577-585.
24. Yamagata, H., N. Taguchi, K. Daishima, and S. Misushima. 1983. Genetic characterization of a gene for prolipoprotein signal peptidase in Escherichia coli. Mol. Gen. Genet. 192:10-14.