Neurotensin and the serotonergic system

Progress in Neurobiology

Volumn 52, Issue 6, 1997, Pages 455-468

  Jolas, Thierry ^a   Aghajanian, George K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTENSIN; PHENYLEPHRINE;

ANALGESIA; AROUSAL; AUTONOMIC NERVOUS SYSTEM FUNCTION; BEHAVIOR; BINDING SITE; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; HUMAN; NOCICEPTION; PRIORITY JOURNAL; REVIEW; SEROTONINERGIC SYSTEM; SLEEP WAKING CYCLE;

ANIMALS; ELECTROPHYSIOLOGY; HUMANS; NEURONS; NEUROTENSIN; RAPHE NUCLEI; SEROTONIN;

EID: 0030833374     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(97)00025-7     Document Type: Review

References (118)

1. Adrien, J. (1995) The serotonergic system and sleep-wakefulness regulation. In The Pharmacology of Sleep, pp. 91-116. Ed. A. Kales. Springer: Berlin.
2. Al-Rodhan, N. R. F., Richelson, E., Gilbert, J. A., McCormick, D. J., Kanba, K. S., Pfenning, M. A., Nelson, A., Larson, E. W. and Yaksh, T. L. (1991) Structure-antinociceptive activity of neurotensin and some novel analogues in the periaqueductal gray region of the brainstem. Brain Res. 557, 227-235.
3. Allen, G. V. and Cechetto, D. F. (1995) Neurotensin in the lateral hypothalamic area: origin and function. Neuroscience 69, 533-544.
4. Alonso, A., Faure, M. P. and Beaudet, A. (1994) Neurotensin promotes oscillatory bursting behavior and is internalized in basal forebrain cholinergic neurons. J. Neurosci. 14, 5778-5792.
5. Aston-Jones, G., Chiang, C. and Alexinsky, T. (1991) Discharge of noradrenergic neurons in behaving rats and monkeys suggests a role in vigilance. Prog. Brain Res. 88, 501-520.
6. Audinat, E., Hermel, J. M. and Crépel, F. (1989) Neurotensin-induced excitation of neurons of the rat's frontal cortex studied intracellularly in vitro. Expl Brain Res. 78, 358-368.
7. Baldino, F. Jr., Davis, L. G. and Wolfson, B. (1985a) Structure-activity studies with carboxy- and amino-terminal fragments of neurotensin on hypothalamic neurons in vitro. Brain Res. 342, 266-272.
8. Baldino, F. Jr., Higgins, G. A., Moke, M. T. and Wolfson, B. (1985b) Primary explants as a model of the hypothalamus in situ. Peptides 6, 249-256.
9. Baldino, F. Jr. and Wolfson, B. (1985) Postsynaptic actions of neurotensin on preoptic-anterior neurons in vitro. Brain Res. 325, 161-170.
10. Baraban, J. M. and Aghajanian, G. K. (1980) Suppression of firing activity of 5-HT neurons in the dorsal raphe by α-adrenoceptor antagonists. Neuropharmacology 19, 355-363.
11. Basbaum, A. I. and Fields, H. L. (1984) Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. A. Rev. Neurosci. 7, 309-338.
12. Behbehani, M. M. and Fields, H. L. (1979) Evidence that an excitatory connection between the periaqueductal grey and the nucleus raphe magnus mediates stimulation produced analgesia. Brain Res. 170, 85-93.
13. Behbehani, M. M. and Pert, A. (1984) A mechanism for the analgesic effect of neurotensin as revealed by behavioral and electrophysiological techniques. Brain Res. 324, 35-42.
14. Behbehani, M. M., Shipley, M. T. and McLean, J. H. (1987) Effect of neurotensin on neurons in the periaqueducal gray: an in vitro study. J. Neurosci. 7, 2035-2040.
15. Beitz, A. J. (1982) The sites of origin of brain stem neurotensin and serotonin projections to the rodent nucleus raphe magnus. J. Neurosci. 2, 829-842.
16. Beitz, A. J., Shepard, R. D. and Wells, W. E. (1983) The periaqueductal gray-raphe magnus projection contains somatastin, neurotensin and serotonin but not cholecystokinin. Brain Res. 261, 132-136.
17. Belcher, G., Ryall, R. W. and Schaffner, R. (1978) The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat. Brain Res. 151, 307-321.
18. Boudin, H., Pélaprat, D., Rostène, W. and Beaudet, A. (1996) Cellular distribution of neurotensin receptors in rat brain: Immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. J. Compar. Neurol. 373, 76-89.
19. Carraway, R. and Leeman, S. (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J. biol. Chem. 248, 6854-6861.
20. Castel, M.-N., Stutzmann, J.-M., Lucas, M., Lafforgue, J. and Blanchard, J.-C. (1988) Effect of I.C.V. administration of neurotensin and analogs on EEG in rats. Peptides 10, 95-101.
21. Chabry, J., Gaudriault, G., Vincent, J. P. and Mazella, J. (1993) Implication of various forms of neurotensin receptors in the mechanism of internalization of neurotensin in cerebral neurons. J. biol. Chem. 268, 17138-17144.
22. Chabry, J., Labbé-Jullié, C., Gully, D., Kitabgi, P., Vincent, J. P. and Mazella, J. (1994) Stable expression of the cloned rat brain neurotensin receptor into fibroblasts: binding properties, photoaffinity labeling, transduction mechanisms, and internalization. J. Neurochem. 63, 19-27.
23. Chien, P.-Y., Farkas, R. H., Nakajima, S. and Nakajima, Y. (1996) Single-channel properties of the nonselective cation conductance induced by neurotensin in dopaminergic neurons. Proc. natn. Acad. Sci. U.S.A. 93, 14917-14921.
24. Clineschmidt, B. V. and McGuffin, J. C. (1977) Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli. Eur. J. Pharmacol. 46, 395-396.
25. Cooper, P. E., Fernstrom, M. H., Rorstad, O. P., Leeman, S. E. and Martin, J. B. (1981) The regional distribution of somatostatin, substance P and neurotensin in human brain. Brain Res. 218, 219-232.
26. Dahlström, D. F. and Fuxe, K. (1964) Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in cell bodies of brain stem neurons. Acta Physiol. Scand. 232(suppl.), 1-55.
27. de León, M., Coveñas, R., Narváez, J. A., Tramu, G., Aguirre, J. A. and Gonzáles-Barón, S. (1991) Distribution of neurotensin-like immunoreactive cell bodies and fibers in the brainstem of the adult male rat. Peptides 12, 1201-1209.
28. Descarries, L., Watkins, K. C., Garcia, S. and Beaudet, A. (1982) The serotonin neurons in the nucleus raphe dorsalis of adult rats: a light and electron microscope radioautographic study. J. Comp. Neurol. 207, 239-254.
29. Dickenson, A. H., Oliveras, J. L. and Besson, J. M. (1979) Role of the raphe magnus in opiate analgesia as studied by the microinjection technique in the rat. Brain Res. 170, 95-111.
30. Emson, P. C., Goedert, M., Horsfield, P., Rioux, F. and St Pierre, S. (1982) The regional distribution and chromatographic characterisation of neurotensin-like immunoreactivity in the rat central nervous system. J. Neurochem. 38, 992-999.
31. Fardin, V., Oliveras, J.-L. and Besson, J.-M. (1984) A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat. The production of behavioral side effects together with analgesia. Brain Res. 306, 105-123.
32. Farkas, R. H., Chien, P.-Y., Nakajima, S. and Nakajima, Y. (1996) Properties of a slow nonselective cation conductance modulated by neurotensin and other neurotransmitters in midbrain dopaminergic neurons. J. Neurophysiol. 76, 1968-1980.
33. Farkas, R. H., Nakajima, S. and Nakajima, Y. (1994) Neurotensin excites basal forebrain cholinergic neurons: ionic and signal-transduction mechanisms. Proc. natn. Acad. Sci. U.S.A. 91, 2853-2857.
34. Fields, H. L. and Anderson, S. D. (1978) Evidence that raphespinal neurons mediate opiate and midbrain stimulation-produced analgesias. Pain 5, 333-349.
35. Fields, H. L., Heinricher, M. M. and Mason, P. (1991) Neurotransmitters in nociceptive modulatory circuits. A. Rev. Neurosci. 14, 219-245.
36. François-Bellan, A.-M., Bosler, O., Tonon, M.-C., Lin-Tong, W. and Beaudet, A. (1992) Association of neurotensin receptors with VIP-containing neurons and serotonin-containing axons in the suprachiasmatic nucleus of the rat. Synapse 10, 282-290.
37. 1-adrenoceptors in rat dorsal raphe neurons. J. Neurosci. 7, 3897-3906.
38. Gray, B. G. and Dostrovosky, J. O. (1983) Descending inhibitory influences from the periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. I. Effects on lumbar spinal cord nociceptive and non-nociceptive neurons. J. Neurophysiol. 49, 932-947.
39. Griersmith, B. T. and Duggan, A. W. (1980) Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide. Brain Res. 187, 231-236.
40. Gully, D., Canton, M., Boigegrain, R., Jeanjean, F., Molimard, J. C., Poncelet, M., Gueudet, C., Heaulme, M., Leyris, R., Brouard, A., Pelaprat, D., Labbé-Jullié, C., Mazella, J., Soubrié, P., Maffrand, J. P., Rostène, W., Kitabgi, P. and Le Fur, G. (1993) Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor. Proc. natn. Acad. Sci. U.S.A. 90, 65-69.
41. Headley, P. M., Duggan, A. W. and Griersmith, B. T. (1978) Selective reduction by noradrenaline and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurones. Brain Res. 145, 417-421.
42. Herbison, A. E., Hubbard, J. I. and Sirett, N. E. (1986) Neurotensin excites neurons in the arcuate nucleus of the rat hypothalamus in vitro. Brain Res. 364, 391-395.
43. Jacobs, B. L. (1986) Single unit activity of locus coeruleus neurons in behaving animals. Prog. Neurobiol. 27, 183-194.
44. Jennes, L., Stumpf, W. E. and Kalivas, P. W. (1982) Neurotensin: topographical distribution in rat brain by immunohistochemistry. J. Compar. Neurol. 210, 211-224.
45. Jiang, Z. G., Pessia, M. and North, R. A. (1994) Neurotensin excitation of rat ventral tegmental neurones. J. Physiol. 474, 119-129.
46. Jolas, T. and Aghajanian, G. K. (1996) Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro. Eur. J. Neurosci. 8, 153-161.
47. Jolas, T. and Aghajanian, G. K. (1997) Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Res. (in press).
48. Kalivas, P. W., Jennes, L., Nemeroff, C. B. and Prange, A. J. Jr. (1982) Neurotensin: Topographical distribution of brain sites involved in hypothermia and antinociception. J. Compar. Neurol. 210, 225-238.
49. Keegan, K. D., Woodruff, G. N. and Pinnock, R. D. (1994) The pharmacology of neurotensin analogues on neurones in the rat substantia nigra, pars compacta in vitro. Eur. J. Pharmacol. 253, 131-137.
50. Kessler, J. P., Moyse, E., Kitabgi, P., Vincent, J. P. and Beaudet, A. (1987) Distribution of neurotensin binding sites in the caudal brainstem of the rat: a light microscopic radioautographic study. Neuroscience 23, 189-198.
51. Kirkpatrick, K. and Bourque, C. W. (1995) Effects of neurotensin on rat supraoptic nucleus neurones in vitro. J. Physiol. 482, 373-381.
52. Kislauskis, E., Bullock, B., McNeil, S. and Dobner, P. (1988) The rat gene encoding neurotensin and neuromedin N: structure, tissue-specific expression, and evolution of exon sequences. J. Biol. Chem. 263, 4963-4968.
53. Kitabgi, P., Rostène, W., Dussaillant, M., Schotte, A., Laduron, P. M. and Vincent, J.-P. (1987) Two populations of neurotensin binding sites in murine brain: discrimination by an antihistaminic, levocabastine, reveals markedly different radioautographic distribution. Eur. J. Pharmacol. 140, 285-293.
54. Llewelyn, M. B., Azami, J. and Roberts, M. H. T. (1983) Effects of 5-hydroxytryptamine applied into nucleus raphe magnus on nociceptive thresholds and neuronal firing rate. Brain Res. 258, 59-68.
55. Long, J. B., Kalivas, P. W., Youngblood, W. W., Prange, A. J. Jr. and Kizer, J. S. (1984) Possible involvement of serotonergic neurotransmission in neurotensin but not morphine analgesia. Brain Res. 310, 35-41.
56. Mai, J. K., Triepel, J. and Metz, J. (1987) Neurotensin in human brain. Neuroscience 22, 499-524.
57. Mazella, J., Amar, S., Bozou, J. C., Kitabgi, P. and Vincent, J.-P. (1987) Functional properties and molecular structure of central and peripheral neurotensin receptors. J. Recept. Res. 7, 157-165.
58. Mazella, J., Chabry, J., Zsürger, N. and Vincent, J.-P. (1989) Purification of the neurotensin receptor from mouse brain by affinity chromatography. J. Biol. Chem. 264, 5559-5563.
59. Mazella, J., Kitabgi, P. and Vincent, J.-P. (1985a) Molecular properties of neurotensin receptors in rat brain. Identification of subunits by covalent labeling. J. Biol. Chem. 260, 508-512.
60. Mazella, J., Kwan, C. Y., Kitabgi, P. and Vincent, J.-P. (1985b) Covalent labeling of neurotensin receptors in rat gastric fundus plasma membranes. Peptides 6, 1137-1141.
61. 11]-neurotensin, a highly radioactive ligand of neurotensin receptors. J. Biol. Chem. 258, 3476-3481.
62. McGinty, D. J. and Harper, R. M. (1976) Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res. 101, 569-575.
63. 3 receptor stimulation in the nucleus tractus solitarius of spontaneously hypertensive rats. Brain Res. 1994, 130-134.
64. 3 receptors in the nucleus tractus solitarius of the rat. Brain Res. 669, 130-134.
65. Mercuri, N. B., Stratta, F., Calabresi, P. and Bernardi, G. (1993) Neurotensin induces an inward current in rat mesencephalic dopaminergic neurons. Neurosci. Lett. 153, 192-196.
66. Messing, R. B. and Lytle, L. D. (1977) Serotonin-containing neurons: their possible role in pain and analgesia. Pain 4, 1-21.
67. Millan, M. J. (1995) Serotonin (5-HT) and pain: a reappraisal of its role in the light of receptor multiplicity. Semin. Neurosci. 7, 409-419.
68. Mills, A., Demoliou-Mason, C. D. and Bernard, E. A. (1988) Purification of the neurotensin receptor from bovine brain. J. Biol. Chem. 263, 13-16.
69. Minagawa, H., Shiosaka, S., Inagaki, S., Sakanaka, M., Takatsuki, K., Ishimoto, I., Senba, E., Kawai, Y., Hara, Y., Matsuzaki, T. and Tohyama, M. (1983) Ontogeny of neurotensin-containing neuron system of the rat: immunohistochemical analysis - II. Lower brain stem. Neuroscience 8, 467-486.
70. 3-neurotensin. Neuroscience 22, 525-536.
71. Mueller, R. A., Lundberg, D. B. A., Breese, G. R., Hedner, J., Hedner, T. and Jonason, J. (1982) The neuropharmacology of respiratory control. Pharmacol. Rev. 34, 255-285.
72. Naranjo, J. R., Arnedo, A., Molinero, M. T. and Del Rio, J. (1989) Involvement of spinal monoaminergic pathways in nociception produced by substance P and neurotensin in rodents. Neuropharmacology 28, 291-298.
73. Nemeroff, C. B., Osbahr, A. J., Manberg, P. J., Ervin, G. N. and Prange, A. J. Jr. (1979) Alterations in nociception and body temperature after intracisternal administration of neurotensin, β-endorphin, other endogenous peptides, and morphine. Proc. natn. Acad. Sci. U.S.A. 76, 5368-5371.
74. Nicot, A., Rostene, W. and Berod, A. (1994) Neurotensin receptor expression in the rat forebrain and midbrain: a combined analysis by in situ hybridization and receptor autoradiography. J. Compar. Neurol. 341, 407-419.
75. Oliveras, J. L., Guilbaud, G. and Besson, J. M. (1979) A map of serotonergic structures involved in stimulation producing analgesia in unrestrained freely moving cats. Brain Res. 164, 317-322.
76. Osbahr, A. J., Nemeroff, C. B., Luttinger, D., Mason, G. A. and Prange, A. J. Jr. (1981) Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone. J. Pharmacol. Expl Ther. 217, 645-651.
77. 1-adrenoceptors in the rat dorsal raphe neurons: regulation of two potassium conductances. J. Physiol. 478, 437-447.
78. Pan, Z. Z. and Williams, J. T. (1989) GABA- and glutamate-mediated synaptic potentials in rat dorsal raphe neurons in vitro. J. Neurophysiol. 61, 719-726.
79. Petrov, T., Jhamandas, J. H. and Krukoff, T. L. (1992) Characterization of peptidergic efferents from the lateral parabrachial nucleus to identified neurons in the rat dorsal raphe nucleus. J. Chem. Neuroanat. 5, 367-373.
80. Pinnock, R. D. (1985) Neurotensin depolarizes substantia nigra dopamine neurones. Brain Res. 338, 151-154.
81. Pinnock, R. D. and Woodruff, G. N. (1994) The non-peptide neurotensin receptor antagonist SR48692 is not a potent antagonist of neurotensin (8-13) responses of rat substantia nigra neurones in vitro. Neurosci. Lett. 172, 175-178.
82. Pomeroy, S. L. and Behbehani, M. M. (1979) Physiologic evidence for a projection from periaqueductal gray to nucleus raphe magnus in the rat. Brain Res. 176, 143-147.
83. 3H]neurotensin receptors in rat brain: visualization by tritium-sensitive film. Peptides 3, 757-763.
84. Rioux, F., Quirion, R., St-Pierre, S., Regoli, D., Jolicoeur, F. B., Belanger, F. and Barbeau, A. (1981) The hypotensive effect of centrally administred neurotensin in rats. Eur. J. Pharmacol. 69, 241-247.
85. Sato, M., Kiyama, H., Yoshida, S., Saika, T. and Tohyama, M. (1991) Postnatal ontogeny of cells expressing prepro-neurotensin/neuromedin N mRNA in the rat forebrain and midbrain: a hybridization histochemical study involving isotope-labeled and enzyme-labeled probes. J. Compar. Neurol. 310, 300-315.
86. Sawchenko, P. E., Swanson, L. W., Steinbush, H. W. M. and Verhofstad, A. A. J. (1983) The distribution and cell origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res. 277, 355-360.
87. Schaffar, N., Kessler, J. P., Bosler, O. and Jean, A. (1988) Central serotonergic projections to the nucleus tractus solitarii: evidence from double labeling study in the rat. Neuroscience 26, 951-958.
88. 3H]neurotensin binding site in rat brain. Naunyn-Schmied. Arch. Pharmacol. 333, 400-405.
89. Seroogy, K., Ceccatelli, S., Schalling, M., Hökfelt, T., Frey, P., Walsh, J., Dockray, G., Brown, J., Buchan, A. and Goldstein, M. (1988) A subpopulation of dopaminergic neurons in the rat ventral mesenphalon contains both neurotensin and cholecystokinin. Brain Res. 445, 88-98.
90. Seroogy, K. B., Mehta, A. and Fallon, J. H. (1987) Neurotensin and cholecystokinin coexistence within neurons of the ventral mesencephalon: projection to forebrain. Expl Brain Res. 68, 277-289.
91. Seutin, V., Massote, L. and Dresse, A. (1989) Electrophysiological effects of neurotensin on dopaminergic neurones of the ventral tegmental area of the rat in vitro. Neuropharmacology 28, 949-954.
92. Shen, K. Z. and North, R. A. (1992a) Muscarine increases cation conductance and decreases potassium conductance in rat locus coeruleus neurones. J. Physiol. 455, 471-485.
93. Shen, K. Z. and North, R. A. (1992b) Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons. Neuroscience 50, 345-353.
94. Shi, W. X. and Bunney, B. S. (1991) Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Res. 543, 315-321.
95. Shipley, M. T., McLean, J. H. and Behbehani, M. M. (1987) Heterogeneous distribution of neurotensin-like immunoreactive neurons and fibers in the midbrain periaqueductal gray of the rat. J. Neurosci. 7, 2025-2034.
96. Stamford, J. A. (1995) Descending control of pain. Br. J. Anaesth. 75, 217-227.
97. Steinberg, R., Brun, P., Fournier, M., Souilhac, J., Rodier, D., Mons, G., Terranova, J. P., Le Fur, G. and Soubrié, P. (1994) SR 48692, a non peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission. Neuroscience 59, 921-929.
98. Stowe, Z. N. and Nemeroff, C. B. (1991) The electrophysiological actions of neurotensin in the central nervous system. Life Sci. 49, 987-1002.
99. Sutin, E. L. and Jacobowitz, D. M. (1988) Immunocytochemical localization of peptides and other neurochemicals in the rat laterodorsal tegmental nucleus and adjacent area. J. Compar. Neurol. 270, 243-270.
100. Tanaka, K., Masu, M. and Nakanishi, S. (1990) Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4, 847-854.
101. Törk, I. (1985) Raphe nuclei and serotonin containing system. In The Rat Nervous System, pp. 43-77. Ed. G. Paxinos. Academic Press: Australia.
102. Triepel, J., Mader, J., Weindl, A., Heinrich, D., Forssmann, W. G. and Metz, J. (1984) Distribution of NT-IR perikarya in the brain of the guinea pig with special reference to cardiovascular centers in the medulla oblongata. Histochemistry 81, 509-516.
103. Trulson, M. E. and Jacobs, B. J. (1979) Raphe unit activity in freely moving cats: correlation with the level of behavioural arousal. Brain Res. 163, 135-150.
104. Uhl, G. R., Goodman, R. R. and Snyder, S. H. (1979) Neurotensin-containing cell bodies, fibers and nerve terminals in the brain stem of the rat: immunohistochemical mapping. Brain Res. 167, 77-91.
105. Urban, M. O. and Smith, D. J. (1993) Role of neurotensin in the nucleus raphe magnus in opioid-induced antinociception from the periaqueductal gray. J. Pharmacol. Expl Ther. 265, 580-586.
106. Van De Kar, L. D. and Lorens, S. A. (1979) Differential serotonergic innervation of individual hypothalamic nuclei and other forebrain regions by the dorsal and median midbrain raphe nuclei. Brain Res. 162, 45-54.
107. 74) are present in a unique location of the midbrain periaqueductal gray of rats. Brain Res. 461, 53-63.
108. Van der Maelen, C. P. and Aghajanian, G. K. (1983) Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289, 109-119.
109. Wang, Q. P., Guan, J.-L. and Nakai, Y. (1995) Synaptic relations of neurotensinergic neurons in the dorsal raphe nucleus. Peptides 16, 1421-1427.
110. Wang, Q. P., Guan, J.-L. and Nakai, Y. (1996) Electron microscopic study of GABAergic synaptic innervation of neurotensin-immunoreactive neurons in the dorsal raphe nucleus. Brain Res. 730, 118-124.
111. Wang, Q. P. and Nakai, Y. (1994) The dorsal raphe: an important nucleus in pain modulation. Brain Res. Bull. 34, 575-585.
112. Wang, Q. P., Ochiai, H. and Nakai, Y. (1992) GABAergic innervation of serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining. Brain Res. Bull. 29, 943-948.
113. Williams, F. G. and Beitz, A. J. (1993) Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception. Brain Res. 611, 87-102.
114. Woulfe, J., Lafortune, L., de Nadai, F., Kitabgi, P. and Beaudet, A. (1994) Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat - II. Immunohistochemical localization of maturation products. Neuroscience 60, 167-181.
115. Wu, T., Li, A. and Wang, H.-L. (1995) Neurotensin increases the cationic conductance of rat substantia nigra dopaminergic neurons through the inositol 1,4,5-triphosphate-calcium pathway. Brain Res. 683, 242-250.
116. Wu, T. and Wang, H.-L. (1995) Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neurosci. Lett. 184, 121-124.
117. Yoshimura, M., Higashi, H. and Nishi, S. (1985) Noradrenaline mediates slow excitatory synaptic potentials in rat dorsal raphe neurons in vitro. Neurosci. Lett. 61, 305-310.
118. Young, W. S. and Kuhar, M. J. (1981) Neurotensin receptor localization by light microscopic autoradiography in rat brain. Brain Res. 206, 273-285.