Quality control in generic anthelmintics: Is it adequate?

Veterinary Parasitology

Volumn 72, Issue 2, 1997, Pages 157-165

  Van Wyk, J A ^a   Malan, F S ^b   Van Rensburg, L J ^a   Oberem, P T ^c   Allan, M J ^b  

^a ONDERSTEPOORT VETERINARY INSTITUTE   (South Africa)

^b Hoechst Research Station   (South Africa)

^c Hoechst Roussel Vet   (South Africa)

Author keywords

Drug resistance; Generic compounds; Haemonchus contortus; Rafoxanide; Sheep nematoda

Indexed keywords

ANTHELMINTIC AGENT; GENERIC DRUG; NASALCUR; RAFOXANIDE; RANOX; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MARKETING; DRUG RESISTANCE; FEMALE; HAEMONCHUS CONTORTUS; INFECTION; NONHUMAN; ORAL DRUG ADMINISTRATION; QUALITY CONTROL; SHEEP; SOUTH AFRICA;

ANIMALS; ANTHELMINTICS; DRUGS, GENERIC; HAEMONCHIASIS; HAEMONCHUS; PARASITE EGG COUNT; QUALITY CONTROL; RAFOXANIDE; SHEEP; SHEEP DISEASES; SOUTH AFRICA;

ANIMALIA; HAEMONCHUS CONTORTUS; NEMATODA; OVIS ARIES;

EID: 0030833086     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4017(97)00022-8     Document Type: Article

References (14)

1. Campbell, N.J., Hall, C.A., Kelly, J.D., Martin, I.C.A., 1978. The arithelmintic efficacy of non-benzimidazole anthelmintics against benzimidazole resistant strains of Haemonchus contortus and Trichostrongylus colubriformis in sheep. Aust. Vet. J. 54, 23-25.
2. Colglazier, M.L., Kates, K.C., Enzie, F.D., 1971. Activity of levamisole, pyrantel tartrate, and rafoxanide against two thiabendazole-tolerant isolates of Haemonchus contortus, and two species of Trichostrongylus, in sheep. Proc. Helminth. Soc. WA 38, 203-205.
3. Groeneveld, H.T., Reinecke, R.K., 1969. A statistical method for comparing worm burdens in two groups of sheep. Onderstepoort J. Vet. Res. 36, 285-298.
4. Horak, I.G., Snijders, A.J., Louw, J.P., 1972. Trials with rafoxanide: 5. Efficacy studies against Fasciola hepatica, Fasciola gigantica, Paramphistomum microbothrium and various nematodes in sheep. J. S. Afr. Vet. Assoc. 43, 397-403.
5. Le Jambre, L.F., Barger, I.A., 1979. Efficiency of rafoxanide and naphthalophos against inhibited Haemonchus contortus. Aust. Vet. J. 55, 346-347.
6. Reinecke, R.K., 1973. The larval anthelmintic test in ruminants. Technical Communication No. 106, Department of Agricultural Technical Services, Republic of South Africa, 20 pp.
7. Shu-Hua, X., Ji-Quing, Y., Hui-Fang, G., Catto, B.A., 1992. Plasma pharmacokinetics and therapeutic efficacy of praziquantel and 4-hydroxypraziquantel in Schistosoma japonicum-infected rabbits after oral, rectal, and intramuscular administration. Am. J. Trop. Med. Hyg. 46, 582-588.
8. Siegel, S., 1956. Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill, New York.
9. Snijders, A.J., Horak, I.G., Louw, J.P., 1973. Trials with rafoxanicle: 6. The effect of repeated and single treatments with rafoxanide against Haemonchus contortus and Oestrus ovis in sheep. J. S. Afr. Vet. Assoc. 44, 251-263.
10. Swan, G.E., Botha, C.J., Taylor, J.H., Mulders, M.S.G., Minnaar, P.P., Kloeck, A., 1995. Differences in the oral bioavailability of three rafoxanide formulations in sheep. J. S. Afr. Vet. Assoc. 66, 197-201.
11. Van Wyk, J.A., Gerber, H.M., 1980a. Survival and development of larvae of the common nematodes of ruminants after long-term cryopreservation and investigation of different routes of infestation. Onderstepoort J. Vet. Res. 47, 129-136.
12. Van Wyk, J.A., Gerber, H.M., 1980b. A field strain of Haemonchus contortus showing slight resistance to rafoxanide. Onderstepoort J. Vet. Res. 47, 137-142.
13. Veglia, F., 1915. The anatomy and life-history of Haemonchus contortus (Rud). Rep. Vet. Res. Un. S. Afr., 3-4, 347-500.
14. Whitlock, H.V., 1959. The recovery and identification of the first stage larvae of sheep nematodes. Aust. Vet. J. 35, 310-316.