Complex PK/PD models - an alcoholic experience

International Journal of Clinical Pharmacology and Therapeutics

Volumn 35, Issue 10, 1997, Pages 465-468

  Holford, N H G ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Ethanol; Pharmacodynamics; Pharmacokinetics; Population approach; Tolerance

Indexed keywords

ALCOHOL;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOL TOLERANCE; ALCOHOLISM; BIOAVAILABILITY; COGNITION; DRUG ABSORPTION; DRUG DISPOSITION; FORENSIC SCIENCE; HUMAN; LIVER BLOOD FLOW; MOTOR COORDINATION; PHARMACODYNAMICS; PHARMACOKINETICS; REVIEW;

AREA UNDER CURVE; BEER; BIOLOGICAL AVAILABILITY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COGNITION; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG TOLERANCE; ETHANOL; HUMANS; MODELS, BIOLOGICAL; MOTOR ACTIVITY;

EID: 0030832855     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (6)

1. Holford NHG 1987 The clinical phar-macokinetics of ethanol. Clin Pharmacokin 13: 273-292
2. Holford NHG 1992 Parametric Models of Drug Action. In: Van Boxtel C, Holford NHG, Danh of M (ed) The In Vivo Study of Drug Action. Elsevier, Amsterdam
3. Holford NHG. Couch RA 1988 The relative (unavailability of ethanol from two New Zealand beers. Am Soc Clin Pharmacol Ther Annual Meeting San Diego, CA, USA
4. Holford NHG, Fraser A 1995 Population phar-macokinetics of ethanol in humans: influence of dose, meals, H2 antagonists, race, and ethanol use. Am Soc Clin Pharmacol Ther 57:2/6
5. Holford NHG, Sheiner LB 1981 Understanding the dose-effect relationship: clinical application of phar-macokinctic-pharmacodynamic models. Clin Pharmacokin ft: 429-453
6. Widmark EMP Die theoretischen Grundlagen und die praktische Verwcn- barkcit der gerichtlich-medizinischen Alkoholbestimmung. Urban und Schwarzenberg, Berlin 1932