A convenient two-step one-pot synthesis of phosphonamidates

Tetrahedron Letters

Volumn 38, Issue 51, 1997, Pages 8803-8806

  Mlodnosky, Karyn L ^a   Holmes, H Michael ^a   Lam, Vinh Q ^a   Berkman, Clifford E ^a  

^a SAN FRANCISCO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHONAMIDE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; REACTION ANALYSIS;

EID: 0030832794     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10421-X     Document Type: Article

References (11)

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3. (b) McLeod, D.A.; Brinkworth, R.I.; Ashley, J.A.; Janda, K.D.; Wirshing, P. Bioorg. Med. Chem. Lett., 1991, 1, 653.
4. (a) Bateson, J.H.; Gasson, B.C.; Khushi, T.; Neale, I.E.; Payne, D.J.; Toison, D.A.; Walker, G. Bioorg. Med. Chem. Lett. 1994, 4, 1667-1672.
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9. Berkman, C.E.; Underiner, G.E.; Cashrnan, J.R. J. Org. Chem. 1996, 61, 5686-5689.
10. 31P NMR, thus resulting in a low yield.
11. 31P NMR chemical shifts (relative to phosphoric acid) for each of the phosphonamidate products and phosphonate diester side-products were as follows: 1a δ 22.1, 22.8; 1b δ 21.7, 22.4; 1c δ 32.9, 33.6; 1d δ 33.6, 34.2; le δ 36.4, 37.0; If δ 37.1, 37.6; 2a: δ 19.3; 2b δ 20.9; 2c δ 32.2; 2e δ 35.3; 2f δ 32.0.