Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir

Journal of Antimicrobial Chemotherapy

Volumn 39, Issue 6, 1997, Pages 821-824

  Hayashi, Kyoko ^a   Hayashi, Toshimitsu ^a   Otsuka, Hidaeki ^b   Takeda, Yoshio ^c  

^a UNIVERSITY OF TOYAMA   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,7 TRIMETHOXYFLAVONE; ACICLOVIR; FLAVONE DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; HERPES SIMPLEX VIRUS 1; HOST CELL; HUMAN CYTOMEGALOVIRUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLIOMYELITIS VIRUS; PROTEIN SYNTHESIS; VIRUS ADSORPTION; VIRUS REPLICATION;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL CULTURE TECHNIQUES; CYTOMEGALOVIRUS; DRUG SYNERGISM; FIBROBLASTS; FLAVONOIDS; HERPESVIRUS 1, HUMAN; HUMANS; LUNG; POLIOVIRUS; VIRUS REPLICATION;

EID: 0030832482     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/39.6.821     Document Type: Article

References (10)

1. Hosozawa, S., Kato, N. & Munakata, K. (1972). 5,6,7-Trimethoxyflavone from Callicarpa japonica. Phytochemistry 11, 2362.
2. Panichpol, K. & Waterman, P. G. (1978). Novel flavonoids from the stem of Popowia cauliflora. Phytochemistry 17, 1363-7.
3. Kutney, J. P. & Hanssen, H. W. H. (1971). 5,6,7-Trimethoxyflavone and 5,6,7,8-tetramethoxyflavone from Zeyhera tuberculosa. Phyiochemistry 10, 3298-302.
4. Ahmad, S. A., Siddiqui, S. A. & Zaman, A. (1974). Flavones from Colebrookia oppositifolia. Indian Journal of Chemistry 12, 1327-8.
5. Hayashi, K., Hayashi, T. & Morita, N. (1992). Mechanism of action of the antiherpesvirus biflavone ginkgetin. Antimicrobial Agents and Chemotherapy 36, 1890-3.
6. Andries, K., Dewindt, B., Snoeks, J., Willebrords, R., Van Eemeren, K., Stokbroekx, R. et al. (1992). In vitro activity of pirodavir (R77975), a substituted phenoxy-pyridazinamine with broadspectrum antipicornaviral activity. Antimicrobial Agents and Chemotherapy 36, 100-7.
7. Elion, G. B., Singer, S. & Hitchings, G. H. (1954). Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of bio- chemically related antimetabolites. Journal of Biological Chemistry 208, 477-88.
8. Mucsi, I., Gyulai, Z. & Béládi, I. (1992). Combined effects of flavonoids and acyclovir against herpesviruses in cell cultures. Acta Microbiologica Hungarica 39, 137-47.
9. Elion, G. B. (1982). Mechanism of action and selectivity of acyclovir. American Journal of Medicine 73, Suppl. 1A, 7-13.
10. Hayashi, K. & Hayashi, T. (1996). Scopadulciol is an inhibitor of herpes simplex virus type 1 and a potentiator of acyclovir. Antiviral Chemistry and Chemotherapy 7, 79-85.