Non-specific binding of IgG1 to Heligmosomoides polygyrus: Adult worm homogenate superantigen is a target for immunoglobulin-induced inhibition

Parasite Immunology

Volumn 19, Issue 10, 1997, Pages 469-474

  Robinson, Michael ^a   Gustad, Thomas R ^a   Erickson, Michele R ^a   Ferouson, Jennifer L ^a   David, Chella S ^b  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

E S; Heligmosomoides polygyrus; IgG1; Nematode; Superantigen

Indexed keywords

IMMUNOGLOBULIN G1; PARASITE ANTIGEN; SUPERANTIGEN;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; MOUSE; NEMATODE; NEMATODIASIS; NONHUMAN; PRIORITY JOURNAL; WORM;

EID: 0030832359     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-152.x     Document Type: Article

References (18)

1. Behnke J. (1987) Evasion of immunity by nemutode parasites causing chronic infections. Advances in Parasitology 26, 1-71
2. Chapman C.B., Knopf P.M., Anders R.F. et al, (1979a) IgGl hypergammaglobulinemia in chronic parasitic infections in mice: evidence that the response reflects chronicity of antigen pressure. Australian Journal of Experimental Biology and Medical Sciences 57, 389-400
3. Chapman C.B., Knopf P.M., Hicks ID. et al, (1979b) IgGI hypergammaglobulinacmia in chronic parasitic infections in mice: magnitude of the response in mice infected with various parasites. Australian Journal of Experimental Biology und Medical Sciences 57, 369-387
4. Jacobson R.H., Brooks B,O. & Cypess R.H. (1982) Immunity to Nematospiroides dubius: parasite stages responsible for and subject to resistance in high responder (LAF1/J) mice, Journal of Parasitology 68, 1053-1058 ::
5. Jenkins S.N. & Behnke J.M. (1977) Impairment or primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius. Partasitology 75, 71-78
6. Kmzin B.L., Leung D.Y.M., Kappler J. & Marrack P. (1993) Superantigens and their potential role in human disease. Advances in Immunology 54, 99-166
7. Marrack P. & Kappler J. (1990) The staphylococcal enterotoxins and their relatives. Science 248, 705-711
8. Marrack P. & Kappler J. (1994) Subversion of the immune system by pathogens. Cell 76, 323-332
9. Mclaren D.J. (1984) Disguise as an evasive strategem of parasitic organisms. Parasiinlogy 88, 597-611
10. Mcrrl C.R., Goldman D., Sedman S.A. et al. (1981) Ultrasensitive stain for proteins in polyacrylumide gels shows regional variation in cerebrospinal fluid proteins. Science 211, 1437-1438
11. Pleass R.J. & Bianco A.E, (1994) The role of adult worms in suppressing functional protective immunity to Heligmosomoides polygyrus bakeri challenge infections. Parasite Immunology 16, 619-628
12. Robinson M. & Gustad T.R. (1996) In vitro stimulation of mouse lymphocytes by Heligmosomoides polygyrus adult worm antigens induces the production of IgGI, Parasite Immunology 18, 87-93
13. Robinson M., Behnke J.M. & Williams D.J.L. (1988) Immunity to adult Heligmosomoides polygyrus (Nematospiroides dubius), Survival or rejection of adult worms following transplantation to mice refractory to larval challenge. Journal of Helminthinthology 62, 221-231
14. Robinson M., Gustad T.R., Wei F.-Y. et al. (1994) Adult worm homogenate of the nematode parasite Heligmosomoides polygyrus induces proliferation of naive T lymphocytes without MHC restriction. Cellular Immunology 158, 157-166
15. Robinson M., Gustad T.R., Storey N. el ul. (1995) Heligmosomoides polygyrus adult worm homogenate superantigen: presentation to T cells requires MHC Class I positive accessory cells. Cellular Immunology 161, 188-194
16. Robinson M., Gustad T,R. & Meinhardt S. (1997) Non-specific binding of mouse IgGI to Heligmosomoides polygyrus: parasite homogenate can purify mouse monoclonal antibodies. Parasitology 114, 79-84
17. Williams D.J.L. & Behnke J.M. (1983) Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunised with the nematode parasite Nematospiroides dubius. Immunology 48, 37-47
18. Wahid F.N. & Behnke J.M. (1993) Immunological relationships during primary infection with Heligmosomoides polygurus (Nematospiroides dubius): parasite specific IgGI antibody responses and primary response phenotype. Purasite Immunology 15, 401-413