Growth factors in age-related macular degeneration: Pathogenic and therapeutic implications

Ophthalmic Research

Volumn 29, Issue 5, 1997, Pages 341-353

  Frank, Robert N ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Age related macular degeneration; Choroidal neovascularization; Growth factors

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; ANTIBODY; BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GROWTH FACTOR; VASCULOTROPIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTORADIOGRAPHY; CELL MEMBRANE; CHOROID CAPILLARY LAYER; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; HUMAN; HUMAN TISSUE; HYPOXEMIA; IMMUNOCYTOCHEMISTRY; KRYPTON LASER; LASER COAGULATION; LYSOSOME; MALE; NONHUMAN; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA MACULA AGE RELATED DEGENERATION; SUBRETINAL NEOVASCULARIZATION;

EID: 0030832082     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000268032     Document Type: Article

References (35)

1. Michaclson IC: The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases, Trans Ophthalmol Soc UK 1948;68:137-180.
2. Pagenstecher H, Genth C: Atlas der pathologischen Anatomic des Augenapfels, Wiesbaden, Kriedel, 1875.
3. Vcrhoeff H, Grossman HP: Pathogenesis of disciform degeneration of the macula, Arch Ophthalmol 1937; 18:561-585.
4. Ryan SJ, Stout JT, Dugcl PU: Sub-retinal neovascularization; in Ryan SJ (ed): Retina, ed 2, St Louis, Mos-by, 1994, vol 2, pp 1027-1047.
5. Gass JDM: Pathogenesis of disciform detachment of the ncuroepi-thelium, I, General concepts and classification, Am J Ophthalmol 1967:63:573-585.
6. Gass JDM: Pathogenesis of disciform detachment of the neuroepithelium, III, Senile disciform macular degeneration, Am J Ophthalmol 1967;63:617-644.
7. Gass JDM: Pathogenesis of disciform detachment of the neuroepithelium, IV, Fluorescein angiographic study of senile disciform macular degeneration, Am J Ophthalmol 1967:63:645-659.
8. Folkman J, Klagsbum M: Angiogenic factors, Science 1987:235:442-447.
9. D’Amore PA: Mechanisms of retinal and choroidal neovascularization, Invest Ophthalmol Vis Sci 1994:35:3974-3979.
10. Frank RN, Sotolongo LB: Growth factors and the retina: Normal vascularization and pathologic neovascularization; in Foa P (ed): Humoral Factors in the Regulation of Tissue Growth, New York, Springer, 1993, pp 18-46.
11. Grant M, Russell B, Fitzgerald C, Merimec TJ: Insulin-like growth factors in vitreous: Studies in control and diabetic subjects with neovascularization, Diabetes 1986:35: 416-420.
12. Sivalingam A, Kenney J, Brown GC, Donoso L: Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy, Arch Ophthalmol 1990:108:869-872.
13. Meyer-Schwickerath R, Pfeiffer A, Blum WF, Freiberger H, Klein M, Lösche C, Röllmann R, Schatz H: Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascu-lar eye disease: Studies in nondia-bctic and diabetic subjects, J Clin Invest 1993:92:2620-2625.
14. Malecazc F, Clamens S, Simorrc-Pinatel V, Mathis A, Chollet P, Fa-vard C, Bayard F, Plout J: Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy, Arch Ophthalmol 1994:112:1476-1482.
15. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Kvamoto MA, Park JE, Nguyen AV, Aiello LM, Ferrara N, King GL: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders, N Engl J Med 1994:331:1480-1487.
16. Peter J, Shweiki D, Itin A, Hemo I, Gnessin H, Keshet E: Hypoxia-induced expression of vascular endothelial growth factor (VEGF) by retinal cells is a common factor in neovascularization, Lab Invest 1995:72: 638-645.
17. Tolentino MJ, Miller JW, Gragoudas ES, Chatzistefanou K, Ferrara N, Adamis AP: Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate, Arch Ophthalmol 1996:114:964-970.
18. Zhang NL, Samadani EE, Frank RN: Mitogcnesis and retinal pigment epithelial cell antigen expression in the rat after krypton laser photocoagulation, Invest Ophthalmol Vis Sci 1993:34:2412-2424.
19. Amin R, Puklin JE, Frank RN: Growth factor localization in choroidal neovascular membranes of age-related macular degeneration, Invest Ophthalmol Vis Sci 1994:35: 3178-3188.
20. Frank RN, Amin RH, Eliott D, Puklin JE, Abrams GW: Basic fibroblast growth factor and vascular endothelial growth factor arc present in epiretinal and choroidal neovascular membranes, Am J Ophthalmol 1996:122:393-403.
21. Reddy VM, Zamora RL, Kaplan 11J: Distribution of growth factors in subfoveal neovascular membranes in age-related macular degeneration and presumed ocular histoplasmosis syndrome, Am J Ophthalmol 1995; 120:291-301.
22. Kvanta A, Algvere PV, Berglin L, Scregard S: Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor, Invest Ophthalmol Vis Sci 1996:37:1929-1934.
23. Ormerod LD, Puklin JE, Frank RN: Long-term outcomes following the surgical removal of advanced subfoveal neovascular membranes in age-related macular degeneration, Ophthalmology 1994:101:1201-1210.
24. Btint-Milam AH, Saari JC: Immu-nocytochemical localization of two retinoid-binding proteins in vertebrate retina, J Cell Biol 1983:97: 703-712.
25. Murata T, Nakagawa K, Khalil A, Ishibashi T, Inomata H, Sueishi K: The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas, Lab Invest 1996:74:819-825.
26. Lutty GA, McLeod DS, Merges C, Diggs A, Ploutit J: Localization of vascular endothelial growth factor in human retina and choroid, Arch Ophthalmol 1996;114:971-977.
27. Lopez, PF, Sippy BD, Lambert HM, Thach AB, Hinton DR: Transdiffer-entiatcd retinal pigment epithelial cells are immunoreactivc for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes, Invest Ophthalmol Vis Sci 1996:37:855-868.
28. Abraham JA, Mergia A, Whang JL, Tumolo A, Friedman J, Hjerrild KA, Gospodarowicz, D, Fiddcs JC: Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor, Science 1986;233:545-548.
29. Vlodavsky I, Fridman R, Sullivan R, Sasse J, Klagsbrun M: Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted, J Cell Physiol 1987; 13: 402-408.
30. Folkman J, Klagsbrun M, Sasse J, Wadz.inski M, Ingber D, Vlodavsky I: A heparin-binding angiogenic protein-basic fibroblast growth factor-is stored within basement membrane, Am J Pathol 1988; 130:393-400.
31. Vigny M, Ollier-Hartmann MP, Lavigne M, Fayein N, Jeanny JC, Laurent M, Courtois Y: Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor, J Cell Physiol 1988:137:321-328.
32. Gonzalez A-M, Buscaglia M, Ong M, Baird A: Distribution of basic fibroblast growth factor in the 18-day rat fetus: Localization in the basement membranes of diverse tissues, J Cell Biol 1990; 110:753-765.
33. Hageman GS, Kirchoff-Rcmpe MA, Lewis GP, Fisher SK, Anderson DH: Sequestration of basic fibroblast growth factor in the primate retinal intcrphotoreceptor matrix, Proc Natl Acad Sci USA 1991:88: 6706-6710.
34. Pepper MS, Ferrara N, Orci L, Mon-tesano R: Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogcnesis in vitro, Biochem Biophys Res Commun 1992;189:824-831.
35. Goto F, Goto K, Weindel K, Folkman J: Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels, Lab Invest 1993:69: 508-517.