A randomized, double-blind, placebo controlled comparison of droperidol, ondansetron, and metoclopramide for the prevention of vomiting following outpatient strabismus surgery in children

Journal of Clinical Anesthesia

Volumn 9, Issue 7, 1997, Pages 551-558

  Scuderi, Phillip E ^a   Weaver Jr , R Grey ^a   James, Robert L ^a   Mims, Grover ^a   Elliott, W Gavin ^a   Weeks, Duke B ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Antiemetic therapy; Droperidol; Emesis; Metoclopramide; Nausea and vomiting; Ondansetron; Pediatrics; Strabismus surgery, pediatric

Indexed keywords

DROPERIDOL; METOCLOPRAMIDE; ONDANSETRON; PLACEBO;

ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HOSPITAL DISCHARGE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTPATIENT; PEDIATRICS; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; STRABISMUS SURGERY; VOMITING;

AMBULATORY SURGICAL PROCEDURES; ANTIEMETICS; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DROPERIDOL; FEMALE; HUMANS; INFANT; MALE; METOCLOPRAMIDE; ONDANSETRON; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; STRABISMUS; VOMITING;

EID: 0030832051     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-8180(97)00143-8     Document Type: Article

References (37)

1. Larsson S, Jonmarker C: Postoperative emesis after pediatric strabismus surgery: the effect of dixyrazine compared to droperidol. Acta Anaesthesiol Scand 1990;34:227-30.
2. Lin DM, Furst SR, Rodarte A: A double-blinded comparison of metoclopramide and droperidol for prevention of emesis following strabismus surgery. Anesthesiology 1992;76:357-61.
3. Patel RI, Hannallah RS: Anesthetic complications following pediatric ambulatory surgery: a 3-yr study. Anesthesiology 1988;69:1009-12.
4. Lerman J, Eustis S, Smith DR: Effect of droperidol pretreatment on postanesthetic vomiting in children undergoing strabismus surgery. Anesthesiology 1986;65:322-5.
5. Broadman LM, Ceruzzi W, Patane PS, Hannallah RS, Ruttimann U, Friendly D: Metoclopramide reduces the incidence of vomiting following strabismus surgery in children. Anesthesiology 1990;72:245-8.
6. Hardy JF, Charest J, Girouard G, Lepage Y: Nausea and vomiting after strabismus surgery in preschool children. Can Anaesth Soc J 1986;33:57-62.
7. Christensen S, Farrow-Gillespie A, Lerman J: Incidence of emesis and postanesthetic recovery after strabismus surgery in children: a comparison of droperidol and lidocaine. Anesthesiology 1989;70: 251-4.
8. Dupre LJ, Stieglitz P: Extrapyramidal syndromes after premedication with droperidol in children. Br J Anaesth 1980;52:831-3.
9. Grimes JD, Hassan MN, Preston DN: Adverse neurologic effects of metoclopramide. Can Med Assoc J 1982; 126:23-5.
10. Casey DE. Metoclopramide side effects [Letter]. Ann Intern Med 1983;98(5 Pt 1) :673-4.
11. 3 antagonist ondansetron. Anesthesiology 1993:78:15-20.
12. McKenzie R, Kovac A, O'Connor T, et al: Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology 1993;78:21-8.
13. Davis A, Krige S, Moyes D: A double-blind randomized prospective study comparing ondansetron with droperidol in the prevention of emesis following strabismus surgery. Anaesth Intensive Care 1995;23:438-43.
14. Rose JB, Martin TM, Corddry DH, Zagnoev M, Kettrick RG: Ondansetron reduces the incidence and severity of poststrabismus repair vomiting in children. Anesth Analg 1994;79:486-9.
15. Ummenhofer W, Frei FJ, Urwyler A, Kern C, Drewe J: Effects of ondansetron in the prevention of postoperative nausea and vomiting in children. Anesthesiology 1994;81:804-10.
16. Furst SR, Rodarte A: Prophylactic antiemetic treatment with ondansetron in children undergoing tonsillectomy. Anesthesiology 1994;81:799-803.
17. Rose JB, Brenn BR, Corddry DH, Thomas PC: Preoperative oral ondansetron for pediatric tonsillectomy. Anesth Analg 1996;82:558-62.
18. Carden PA, Mitchell SL, Waters KD, Tiedemann K, Ekert H: Prevention of cyclophosphamide/cytarabine-induced emesis with ondansetron in children with leukemia. J Clin Oncol 1990;8:1531-5.
19. Stevens RF: The role of ondansetron in paediatric patients: a review of three studies. Eur J Cancer 1991;27Suppl 1:S20-2.
20. 3 antagonist ondansetron - an effective outpatient anti-emetic in cancer treatment. Arch Dis Child 1990;65:822-5.
21. Aldrete JA, Kroulik D: A postanesthetic recovery score. Anesth Analg 1970;49:924-34.
22. Chung F: Are discharge criteria changing? J Clin Anesth 1993;5(6 Suppl 1) :64S-68S.
23. Steward DJ: A simplified scoring system for the post-operative recovery room. Can Anaesth Soc J 1975;22:111-3.
24. Brown RE Jr, James DJ, Weaver RG, Wilhoit RD, Bauman LA: Low-dose droperidol versus standard-dose droperidol for prevention of postoperative vomiting after pediatric strabismus surgery. J Clin Anesth 1991;3:306-9.
25. Carmer SG, Swanson MR: An evaluation of ten pairwise multiple comparison procedures by Monte Carlo methods. J Am Stat Assoc 1973;68:66-74.
26. Litman RS, Wu CL, Lee A, Griswold JD, Voisine R, Marshall C: Prevention of emesis after strabismus repair in children: a prospective, double-blinded, randomized comparison of droperidol versus ondansetron. J Clin Anesth 1995;7:58-62.
27. Van den Berg AA, Lambourne A, Yazji NS, Laghari NA: Vomiting after ophthalmic surgery. Effects of intra-operative antiemetics and postoperative oral fluid restriction. Anesthesia 1987;42:270-6.
28. Abramowitz MD, Elder PT, Friendly DS, Broughton WL, Epstein BS: Antiemetic effectiveness of intraoperatively administered droperidol in pediatric strabismus outpatient surgery - preliminary report of a controlled study. J Pediatr Ophthalmol Strabismus 1981;18:22-7.
29. Weinstein MS, Nicolson SC, Schreiner MS: A single dose of morphine sulfate increases the incidence of vomiting after out-patient inguinal surgery in children. Anesthesiology 1994;81:572-7.
30. Watcha MF, Simeon RM, White PF, Stevens JL: Effect of propofol on the incidence of postoperative vomiting after strabismus surgery in pediatric outpatients. Anesthesiology 1991;75:204-9.
31. King MJ, Milazkiewicz R, Carli F, Deacock AR: Influence of neostigmine on postoperative vomiting. Br J Anaesth 1988;61:403-6.
32. Andersen R, Krohg K: Pain as a major cause of postoperative nausea. Can Anaesth Soc J 1976;23:366-9.
33. Yogendran S, Asokumar B, Cheng DC, Chung F: A prospective randomized double-blinded study of the effect of intravenous fluid therapy on adverse outcomes on outpatient surgery. Anesth Analg 1995;80:682-6.
34. Fisher DM: Surrogate end points. Are they meaningful? Anesthesiology 1994;81:795-6.
35. Watcha MF, Smith I: Cost-effectiveness analysis of antiemetic therapy for ambulatory surgery. J Clin Anesth 1994;6:370-7.
36. Dexter F, Tinker JH: Analysis of strategies to decrease postanesthesia care unit costs. Anesthesiology 1995;82:94-101.
37. Orkin FK: Moving toward value-based anesthesia care. J Clin Anesth 1993;5:91-8.