Microsomal catalyzed N-hydroxylation of guanfacine and reduction of N-hydroxyguanfacine

Archiv der Pharmazie

Volumn 330, Issue 9-10, 1997, Pages 303-306

  Clement, Bernd ^a   Demesmaeker, Mark ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Guanfacine; N hydroxylation; N reduction

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; GUANFACINE; N HYDROXYGUANFACINE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG TRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RABBIT; SWINE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GUANFACINE; GUANIDINES; HUMANS; HYDROXYLATION; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; RABBITS; SWINE;

EID: 0030831637     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19973300907     Document Type: Article

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