Pharmacokinetics and metabolism of riluzole

Drugs of Today

Volumn 33, Issue 8, 1997, Pages 587-594

  Martinet, Michel ^a   Montay, Guy ^a   Rhodes, Gerry ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMITRIPTYLINE; AMOXICILLIN; BACLOFEN; CAFFEINE; CAPTOPRIL; CIMETIDINE; CLOMIPRAMINE; CYTOCHROME P450; DIAZEPAM; DICLOFENAC; DRUG METABOLITE; ENALAPRIL; ENOXACIN; IMIPRAMINE; METRONIDAZOLE; NICERGOLINE; PARACETAMOL; PEFLOXACIN; PIRACETAM; PYRIDOXINE; QUININE; RANITIDINE; RILUZOLE; RP 65077; RP 65110; RP 65331; THEOPHYLLINE; THIAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG TRANSFORMATION; FEMALE; HUMAN EXPERIMENT; HUMAN TISSUE; ISOTOPE LABELING; MALE; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REVIEW; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

EID: 0030831411     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.1997.33.8.446334     Document Type: Review

References (5)

1. Gaillard, C., Sanderink, G., Marlard, M., Monegier, B., Chapelle, P., Martinet, M. In vitro and in vivo metabolism of riluzole in animals and man. Drug Metab Dispos, submitted.
2. Sanderink, G.J., Bournique, B., Stevens, J., Petry, M., Martinet, M. Involvement of cytochrome P450 CYP1A isoenzymes in the hepatic metabolism and drug interactions of riluzole in vitro. J Pharmacol Exp Ther, accepted.
3. Le Liboux, A., Lefebvre, P., Le Roux, Y. et al. Single-and multiple-dose pharmacokinetics of riluzole in white subjects. J Clin Pharmacol, accepted.
4. Bruno, R., Vivier, N., Montay, G. et al. Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis. Clin Pharmacol Ther, accepted.
5. Bryson, H.M., Fulton, B., Benfield, P. Riluzole, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs 1996, 52 (4).