Insect neuropeptide leucopyrokinin analogues - Synthesis and antinociceptive effect in rats

Polish Journal of Pharmacology

Volumn 49, Issue 2-3, 1997, Pages 119-126

  Plech, Andrzej ^a   Rykaczewska Czerwińska, Monika ^a   Bartosz Bechowski, Hubert ^b   Lombarska Śliwińska, Danuta ^b   Małota, Marek ^a   Szewczyk, Marek ^a   Brus, Ryszard ^a   Konopińska, Danuta ^b  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

Author keywords

Antinociceptive effects of leucopyrokinin analogues; Leucopyrokinin; Leucopyrokinin analogues; Synthesis of leucopyrokinin analogues

Indexed keywords

ANTINOCICEPTIVE AGENT; LEUCOPYROKININ; LEUCOPYROKININ DERIVATIVE; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ANTINOCICEPTION; ARTICLE; DRUG DETERMINATION; DRUG EFFECT; DRUG SYNTHESIS; FEMALE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; RAT;

AMINO ACID SEQUENCE; AMINO ACIDS; ANALGESICS; ANIMALS; FEMALE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; NEUROPEPTIDES; OLIGOPEPTIDES; PAIN; PYRROLIDONECARBOXYLIC ACID; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030831285     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. 10.
2. Banks W. A., Kastin A. J.: Peptides and blood-brain lipophilicity as a predictor of permeability. Brain Res. Bull., 1985, 15, 287-292.
3. Bartosz-Bechowski H., Lombarska-Śliwińska D., Plech A., Rykaczewska-Czerwińska M., Małota M., Szewczyk M., Sobótka W., Konopińska D.: Antinociceptive effect of the insect neuropeptide leucopyrokinin (LPK or Lem-PK) and its analogues in rats. In: Insects: chemical, physiological and environmental aspects, Proceedings of the First International Conference on Insects, La + (combining ogonek)dek-Zdrój, Poland, 1994, edited by the University of Wrocław, 258-261.
4. Hendrich A. B., Konopińska D.: Interactions of selected insect neuropeptides with synthetic lipids. Gen. Physiol. Biophys., 1992, 11, 251-260.
5. Janssen P. A. J., Niemegeers C. J. E., Dony J. G. H.: The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water-induced tail withdrawal reflex in rats. Arzneim.-Forsch.-Drug Res., 1963, 13, 502-507.
6. Konopińska D., Rosiński G., Sobótka W.: Insect peptide hormones an overview of the present literature. Int. J. Peptide Protein Res., 1992, 39, 1-11.
7. Konopińska D., Sobótka W., Lesicki A., Rosiński G., Sujak P.: Synthesis of proctolin analogs and their cardioexcitatory effect on cockroach - Periplaneta americana L. and yellow mealworm - Tenebrio molitor L. Int. J. Peptide Protein Res., 1986, 27, 597-603.
8. Lombarska-Śliwińska D., Rosiński G., Bartosz-Bechowski H., Stronczak W., Plech A., Brus R., Sobótka W., Konopińska D.: Some insect allatoregulating peptides synthetic and biological studies. Bull. Pol. Acad. Sci. - Chem., 1995, 43, 33-40.
9. Martin W. R., Eades C. G., Thompson J. A., Huppler R. E., Gilbert P. E.: The effects of morphine and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther., 1976, 197, 517-532.
10. Nachman R. J., Holman G. M., Cook B. J.: Active fragments and analogs of the insect neuropeptide leuropyrokinin: structure - function studies. Biochem. Biophys. Res. Commun., 1986, 137, 936-942.
11. O'Callaghan J. P., Holtzman S. G.: Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J. Pharmacol. Exp. Ther., 1975, 192, 497-505.
12. 2]-proctolin on central nervous system in rats. Bull. Pol. Acad. Sci. -Biol., 1992, 40, 85-90.
13. Rykaczewska-Czerwińska M., Konopińska D., Plech A.: Further studies on central antinociceptive effects of leucopyrokinins (unpublished data).
14. Rykaczewska M., Konopińska D., Sobótka W., Brus R., Plech A.: Antinociceptive effect of [2-8]-leucopyrokinin analog ([2-8]-LPK) in rats. Peptydy 91, XI Polskie Sympozjum Peptydowe, Łódź 1991. Abstracts, p. 10.
15. Szekely J. L., Dunai-Kovacs Z., Miglecz E., Ronai A. Z., Bajusz S.: In vivo antagonism by naloxone of morphine, β-endorphin and synthetic enkephalin analog. J. Pharmacol. Exp. Ther., 1978, 207, 878-883.