Pentoxifylline reduces nephrotoxicity associated with cyclosporine in the rat by its rheological properties

Transplantation

Volumn 64, Issue 10, 1997, Pages 1404-1407

  Albornoz, Liliana E ^a   Sanchez, Susana B ^a   Bandi, Juan Carlos ^a   Canteros, Griselda ^a   De Las Heras, Marcelo ^a   Mastai, Ricardo C ^a  

^a HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; PENTOXIFYLLINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD RHEOLOGY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; GLOMERULUS FILTRATION RATE; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY GRAFT REJECTION; KIDNEY PLASMA FLOW; KIDNEY TRANSPLANTATION; MALE; NEPHROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030831117     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199711270-00005     Document Type: Article

References (30)

1. Cohen DJ, Loertscher R, Rubin MF, Tilney NL, Carpenter CB, Strom TB. Cyclosporine: a new immunosuppressive agent for organ trasplantation. Am Intern Med 1984; 101: 667.
2. Humes HD, Jackson NM, O'Connor RP, Hunt DA, White MD. Pathogenetic mechanisms of nephrotoxicity: insights into cyclosporine nephrotoxicity. Transplant Proc 1985; 17: 51.
3. English J, Evan A, Houghton DC, Bennett WM. Cyclosporine-induced acute renal dysfunction in the rat: evidence of arteriolar vasoconstriction with preservation of tubular function. Transplantation 1987; 44(1): 135.
4. Voss Bl, Hamilton KK, Scott Samaraa EN, Mc Kee PA. Cyclosporine supression of endothelial prostacyclin generation. Transplantation 1988; 45(4): 793.
5. Bloom ITM, Bentley FR, Spain DA, Garrison RN. An experimental study of altered nitric oxide metabolism as a mechanism of cyclosporin-induced renal vasoconstriction. Br J Surg 1995; 82: 195.
6. Murray BM, Paller MS, Ferris TF. Effect of cyclosporine administration on renal hemodynamics in conscious rats. Kidney Int 1985; 28: 767.
7. 2: possible relevance to the reduction in glomerular filtration rate. J Pharmacol Exp Ther 1986; 239: 229.
8. Perico N, Benigni A, Zoja C, Delaissi F, Remuzzi G. Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporine A. Am J Physiol 1986; 251: F581.
9. Kon V, Sugiura M, Inagami T, Harvie BR, Ichikawa I, Hoover RL. Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int 1990; 37: 1487.
10. Bloom ITM, Bentley FR, Garrison RN. Acute cyclosporine-induced renal vasoconstriction is mediated by endothelin-1. Surgery 1993; 114: 480.
11. Yanigasawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332(31): 411.
12. Rabelink TJ, Kaasjager KAH, Boer P, Stroes E, Braam B, Koomans HA. Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology. Kidney Int 1994; 46: 376.
13. Bilto YY, Player M, Stuart J. Rheological action of oxpentifylline and structurally-related xanthine derivatives on human erythrocytes. Clin Hemorheol 1988; 8: 213.
14. Schmalzer EA, Chien S. Filterability of subpopulations of leukocytes: effect of pentoxifylline. Blood 1984; 64(2): 542.
15. Weithman KU. Reduced platelet aggregation by pentoxifylline stimulated prostacyclin release. Vasa 1981; 10(3): 249.
16. Luke DR, Vadiei K, Brunner LJ. Time-dependent pharmacokinetics and toxicity of cyclosporine. Chronobiol Int 1988; 5: 353.
17. Brunner LJ, Vadiei K, Iyer LV, Luke D. Prevention of cyclosporine-induced nephrotoxicity with pentoxifylline. Renal Failure 1989; 11(2/3): 97.
18. Vadiei K, Brunner LJ, Luke DR. In vitro and in vivo effects of pentoxifylline in experimental acute renal failure. Kidney Int 1989; 36: 466.
19. Highashi A, Peters L. A rapid colorimetric method for the determination of inulin in plasma and urine. J Lab Clin Med 1950; 35: 475.
20. Smith HW, Finkelstein N, Aliminosa L, Crawford B. The renal clearance of substituted hippuric acid derivatives and other aromatic acid in dog and man. J Clin Invest 1945; 24: 388.
21. Bull B, Chien S, Dormandy J, et al. Guidelines for measurement of blood viscosity and erythrocyte deformability. Clin Hemorheol 1986; 6: 439.
22. Reid H, Barnes P, Lock J, Dormandy A. A sample method for measuring erythrocyte deformability. J Clin Pathol 1976; 29: 855.
23. Kawaguchi A, Goldman MN, Shapiro R, Foegh ML, Ramwell PW, Lower RR. Increase in urinary thromboxane B2 in rats caused by cyclosporine. Transplantation 1985; 40: 214.
24. Grace A, Barradas M, Mikhailidis D, et al. Cyclosporine A enhances platelet aggregation. Kidney Int 1987; 32: 889.
25. Skorecki KL. Rutledge WP, Schrier RW. Acute cyclosporine nephrotoxicity. Prototype for a renal membrane signalling disorder. Kidney Int 1992; 42: 1.
26. Stahl RAK, Kudelba S. Chronic cyclosporine A treatment reduces prostaglandin E2 formation in isolated glomeruli and papilla of rat kidneys. Clin Nephrol 1986; 25(1): 578.
27. Berkenboom G, Fang ZY, Unger P, Goldman M, Fontaine J. Endothelium-dependent effects of pentoxifylline in rat aorta. Eur J Pharmacol 1991, 193: 81.
28. Berkenboom G, Unger P, Goldman M, Fang ZY, Fontaine J. Prevention of cyclosporine A-induced vascular toxicity by pentoxifylline. J Cardiovasc Pharmacol 1991; 18(5): 761.
29. Schut NH, Bilo HJ, Popp-Snijders C, Goedhart PT, Wilmink JM. Erythrocyte deformability, endothelin levels, and renal function in cyclosporin-treated renal transplant recipients: effects of intervention with fish oil and corn oil. Scand J Clin Lab Invest 1993; 53(5): 499.
30. Reinhart WH. Binding of cyclosporine by erythrocytes: influence on cell shape and deformability. Eur J Clin Invest 1993; 23: 177.