The identification of 1,6'- and 1,3'-di-N-(L-4-amino-2-hydroxybutyryl) derivatives of kanamycin as synthetic byproducts of amikacin

Journal of Antibiotics

Volumn 50, Issue 10, 1997, Pages 887-889

  Gunawardana, Geewananda ^a,b   Childress, Curtis ^a   Tripp, Meridith ^a   Zhang, Xiaolin ^a   West, Paul ^a  

^a ABBOTT LABORATORIES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; KANAMYCIN DERIVATIVE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DEUTERON NUCLEAR MAGNETIC RESONANCE; DRUG PURITY; DRUG STRUCTURE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0030830576     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.887     Document Type: Article

References (6)

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2. NAITO, T.; S. NAKAGAWA, Y. ABE, S. TODA, K. FUJISAWA, T. MIYAKI, H. KOSHIYAMA, H. OHKUMA & H. KAWAGUCHI: Aminoglycoside antibiotics. II. Configurational and positional isomers of BB-K8. J. Antibiotics 26: 297-301, 1973
3. Pharmacopeial Forum, The United States Pharmcopeial Convention, Inc., Vol. 21, No. 4, page 939, 1995
4. PIANTINI, V.; O. W. SØRENSON & R. R. ERNEST: Multiple quantum filters for elucidating NMR coupling networks. J. Am. Chem. Soc. 104: 6800-6801, 1982
5. BAX, A. J. & M. F. SUMMERS: H-1 and C-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR. J. Am. Chem. Soc. 108: 2039-2094, 1986
6. MULLER, L.: Sensitivity enhanced detection of weak nuclei using heteronuclear multiple quantum coherence. J. Am. Chem. Soc. 101: 4481-4484, 1979