Targeting endothelium for gene therapy via receptors up-regulated during angiogenesis and inflammation

Cancer Immunology Immunotherapy

Volumn 45, Issue 3-4, 1997, Pages 149-151

  Wickham, Thomas J ^a   Haskard, Dorian ^b   Segal, David ^c   Kovesdi, Imre ^a  

^a GENVEC INC   (United States)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Gene therapy; Inflammation; Receptors

Indexed keywords

BISPECIFIC ANTIBODY; MONOCLONAL ANTIBODY; VIRUS VECTOR;

ADENOVIRUS; ANGIOGENESIS; ANTIGEN BINDING; ARTICLE; ENDOTHELIUM CELL; EXPRESSION VECTOR; GENE TARGETING; GENE THERAPY; HUMAN; IMMUNOTHERAPY; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ADENOVIRIDAE; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; E-SELECTIN; ENDOTHELIUM, VASCULAR; GENE THERAPY; GENETIC VECTORS; INTEGRIN ALPHAV; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDES; UP-REGULATION;

EID: 0030830511     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050419     Document Type: Article

References (13)

1. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (1997) Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:13201323
2. Douglas JT, Rogers BE, Rosenfeld ME, Michael SI, Feng M, Curiel DT (1996) Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 14:1574-1578
3. Gall J, Kass-Eisler A, Leinwand L, Falck-Pedersen E (1996) Adenovirus type 5 and 7n capsid chimera: fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes. J Virol 70:2116-2123
4. Goldman CK, Rogers BE, Douglas JT, Sossnowski BA, Ying W, Siegal GP, Baird A, Campain JA, Curiel DT (1997) Targeted gene delivery to Kaposi's sarcoma cells via the fibroblast growth factor receptor. Cancer Res 57:14471451
5. Hong SS, Karayan SL, Tournier J, Curiel DT, Boulanger PA (1997) Adenovirus type 5 fiber knob binds to MHC class I α2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J 16:22942306
6. Keelan ET, Licence ST, Peters AM, Binns RM, Haskard DO (1994) Characterization of E-selectin expression in vivo with use of a radiolabeled monoclonal antibody. Am J Physiol 266:H279H290
7. Ktrasnykh VN, Mikheeva GV, Douglas JT, Curiel DT (1996) Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol 70:68396846
8. Michael SI, Hong JS, Curiel DT, Engler JA (1995) Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther 2:660668
9. Stevenson SC, Rollence M, Marshall-Neff J, McClelland A (1997) Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein. J Virol 71:47824790
10. Tomko RP, Xu R, Philipson L (1997) HCAR and MCAR: the human and mouse cellular receptors for subgroup C andenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 94:33523356
11. Wickham T, Mathias JP, Cheresh DA, Nemerow GR (1993) Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 73:309319
12. Wickham TJ, Roelvink PW, Brough DE, Kovesdi I (1996) Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types. Nat Biochtechnol 14:15701573
13. Wickham TJ, Segal DM, Roelvink PW, Carrion ME, Lizonova A, Lee GM, Kovesdi I (1996) Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies. J Virol 70:68316838