Role of androgens in testicular tumor development in inhibin-deficient mice

Endocrinology

Volumn 138, Issue 11, 1997, Pages 5000-5005

  Shou, Weinian ^a   Woodruff, Teresa K ^b   Matzuk, Martin M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ANDROGEN; INHIBIN; MYELOPID; SEX HORMONE;

ADRENAL CORTEX CARCINOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CACHEXIA; CONTROLLED STUDY; FEMALE; GONADECTOMY; HORMONE DEFICIENCY; MALE; MOUSE; MUSCLE ATROPHY; NONHUMAN; PENETRANCE; PRIORITY JOURNAL; SEX CORD TUMOR; TESTICULAR FEMINIZATION; TESTIS TUMOR; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0030830218     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.11.5499     Document Type: Article

References (16)

1. Vale W, Bilezikjian LM, Rivier C 1994 Reproductive and other roles of inhibins and activins. In: Knobil E Neill JD (eds) The Physiology of Reproduction. Raven Press, New York, pp 1861-1878
2. Matzuk MM, Kumar TR, Shou W, Coerver KA, Lau AL, Behringer RR, Finegold MJ 1996 Transgenic models to study the roles of inhibins and activins in reproduction, development and oncogenesis. Recent Prog Horm Res 51:123-157
3. Matzuk MM, Finegold MJ, Su J-GJ, Hsueh AJW, Bradley A 1992 α-Inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature 360:313-319
4. Matzuk MM, Finegold MJ, Mather JP, Krummen L, Lu H, Bradley A 1994 Development of cancer cachexia-like syndrome and adrenal tumors in inhibindeficient mice. Proc Natl Acad Sci USA 91:8817-8821
5. Deleted in proof
6. Kumar TR, Wang Y, Matzuk MM 1996 Gonadotropins are essential modifier factors for gonadal tumor development in inhibin-deficient mice. Endocrinology 137:4210-4216
7. Tennent BJ, Shultz KL, Beamer WG 1993 Genetic susceptibility for C19 androgen induction of ovarian granulosa cell tumorigenesis in SWXJ strains of mice. Cancer Res 53:1059-1063
8. Beamer WG, Shultz KL, Tennent BJ, Shultz LD 1993 Gvanulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res 53:3741-3746
9. Charest NJ, Zhou Z-X, Lubahn DB, Olsen KL, Wilson EM, French FS 1991 A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse. Mol Endocrinol 5:573-581
10. He WW, Kumar MV, Tindall DJ 1991 A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse. Nucleic Acids Res 19:2373-2378
11. Green MC 1990 Genetic variants and strains of the laboratory mouse. Oxford University Press, Oxford
12. Wong WL, Garg SJ, Woodruff T, Bald L, Fendly B, Lofgren JA 1993 Monoclonal antibody based ELISAs for measurement of activins in biological fluids. J Immunol Methods 165:1-10
13. Coerver KA, Woodruff TK, Finegold MJ, Mather J, Bradley A, Matzuk MM 1996 Activin signaling through activin receptor type II causes the cachexia-like syndrome in inhibin-deficient mice. Mol Endocrinol 10:1534-1543
14. Matzuk MM, Finegold MJ, Mishina Y, Bradley A, Behringer RR 1995 Synergistic effects of inhibins and Müllerian-inhibiting substance on testicular tumorigenesis. Mol Endocrinol 9:1337-1345
15. Slotman BJ, Rao BR 1989 Response to inhibition of androgen action on human ovarian cancer cells in vitro. Cancer Lett 45:213-220
16. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11162-11166