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Volumn 11, Issue 12, 1997, Pages 1033-1038

Development of pathogenic anti-DNA antibodies in patients with systemic lupus erythematosus

Author keywords

Cationic; Germline V gene; Somatic mutation

Indexed keywords

DNA ANTIBODY;

EID: 0030830158     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.12.9337156     Document Type: Article
Times cited : (39)

References (66)
  • 2
    • 0022273898 scopus 로고
    • Murine models of systemic lupus erythematosus
    • Theofilopoulos, A. N., and Dixon, F. J. (1985) Murine models of systemic lupus erythematosus. Adv. Immunol. 37, 269-390
    • (1985) Adv. Immunol. , vol.37 , pp. 269-390
    • Theofilopoulos, A.N.1    Dixon, F.J.2
  • 3
    • 0342664534 scopus 로고
    • Auto-antibodies in systemic lupus erythematosus
    • (McCarty, D.J., and Koopman, W.J., eds) Lea & Febiger, Philadelphia
    • Tan, E. M. (1993) Auto-antibodies in systemic lupus erythematosus. In Arthritis and Allied Conditions: a Textbook of Rheumatology, 12th ed (McCarty, D.J., and Koopman, W.J., eds) pp. 1179-1184, Lea & Febiger, Philadelphia
    • (1993) Arthritis and Allied Conditions: A Textbook of Rheumatology, 12th Ed , pp. 1179-1184
    • Tan, E.M.1
  • 4
    • 0007915241 scopus 로고
    • Pathogenesis of systemic lupus erythematosus
    • (Kelley, W. N., Harris, E. D., Ruddy, S., Jr., and Sledse, C. B., eds) W. B. Saunders, Philadelphia
    • Woods, V. L., Jr., and Zvaifler, N.J. (1989) Pathogenesis of systemic lupus erythematosus. In Textbook of Rheumatology, 3rd ed (Kelley, W. N., Harris, E. D., Ruddy, S., Jr., and Sledse, C. B., eds) Vol. 2, pp. 1077-1100, W. B. Saunders, Philadelphia
    • (1989) Textbook of Rheumatology, 3rd Ed , vol.2 , pp. 1077-1100
    • Woods Jr., V.L.1    Zvaifler, N.J.2
  • 5
    • 0018756433 scopus 로고
    • Circulating DNA: Anti-DNA complexes in systemic lupus erythematosus: detection and characterization by ultracentrifugation
    • Bruneau, C., and Benveniste, J. (1979) Circulating DNA: anti-DNA complexes in systemic lupus erythematosus: detection and characterization by ultracentrifugation. J. Clin. Invest. 64, 191-198
    • (1979) J. Clin. Invest. , vol.64 , pp. 191-198
    • Bruneau, C.1    Benveniste, J.2
  • 6
    • 0025282645 scopus 로고
    • Anti-DNA antibodies and lupus nephritis: The complexity of crossreactivity
    • Brinkman, K., Termaat, R., Berden, J. H. M., and Smeenk, R. J. T. (1990) Anti-DNA antibodies and lupus nephritis: the complexity of crossreactivity. Immunol. Today 11, 232-234
    • (1990) Immunol. Today , vol.11 , pp. 232-234
    • Brinkman, K.1    Termaat, R.2    Berden, J.H.M.3    Smeenk, R.J.T.4
  • 7
    • 0024506642 scopus 로고
    • Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney
    • Raz, E., Brezis, M., Rosenmann, E., and Eilat, D. (1989) Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney. J. Immunol. 142, 3076-3082
    • (1989) J. Immunol. , vol.142 , pp. 3076-3082
    • Raz, E.1    Brezis, M.2    Rosenmann, E.3    Eilat, D.4
  • 8
    • 0018872434 scopus 로고
    • Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: Comparison of antibodies in serum and renal eluates
    • Ebling, F., and Hahn, B. H. (1980) Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: comparison of antibodies in serum and renal eluates. Arthritis Rheum. 23, 392-403
    • (1980) Arthritis Rheum. , vol.23 , pp. 392-403
    • Ebling, F.1    Hahn, B.H.2
  • 9
    • 0023256118 scopus 로고
    • Induction of a cationic shift in IgG anti-DNa autoantibodies: Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis
    • Datta, S. K., Patel, H., and Berry, D. (1987) Induction of a cationic shift in IgG anti-DNA autoantibodies: role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J. Exp. Med. 165, 1252-1268
    • (1987) J. Exp. Med. , vol.165 , pp. 1252-1268
    • Datta, S.K.1    Patel, H.2    Berry, D.3
  • 10
    • 0023277281 scopus 로고
    • Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits
    • Madaio, M. P., Carlson, J., Cataldo, J., Ucci, A., Migliorini, P., and Pankewycz, O. (1987) Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. Immunol 138, 2883-2889
    • (1987) J. Immunol , vol.138 , pp. 2883-2889
    • Madaio, M.P.1    Carlson, J.2    Cataldo, J.3    Ucci, A.4    Migliorini, P.5    Pankewycz, O.6
  • 11
    • 0025224956 scopus 로고
    • A small proportion of cationic antibodies in immune complexes is sufficient to mediate their deposition in glomeruli
    • Gauthier, V. J., and Mannik, M. (1990) A small proportion of cationic antibodies in immune complexes is sufficient to mediate their deposition in glomeruli. J. Immunol. 145, 3348-3352
    • (1990) J. Immunol. , vol.145 , pp. 3348-3352
    • Gauthier, V.J.1    Mannik, M.2
  • 12
    • 0027283943 scopus 로고
    • Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus
    • Suzuki, N., Harada, T., Mizushima, Y., and Sakane, T. (1993) Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus. J. Immunol. 151, 1128-1136
    • (1993) J. Immunol. , vol.151 , pp. 1128-1136
    • Suzuki, N.1    Harada, T.2    Mizushima, Y.3    Sakane, T.4
  • 13
    • 0001202762 scopus 로고
    • Systemic lupus erythematosus: Clinical aspects and treatment
    • (McCarty, D. J., and Koopman, W. J., eds) Lea & Febiger, Philadelphia
    • Rothfield, N. F. (1993) Systemic lupus erythematosus: clinical aspects and treatment. In Arthritis and Allied Conditions: a Textbook of Rheumatology, 12th ed (McCarty, D. J., and Koopman, W. J., eds) pp. 1155-1177, Lea & Febiger, Philadelphia
    • (1993) Arthritis and Allied Conditions: A Textbook of Rheumatology, 12th Ed , pp. 1155-1177
    • Rothfield, N.F.1
  • 14
    • 0022544539 scopus 로고
    • Cross-reactivity of human and murine anti-DNA antibodies with heparan sulphate: The major glycosaminoglycan in glomerular basement membranes
    • Faaber, P., Rijke, T. P. M., Van de Putte, L. B. A., Capel, P. J. A., and Berden, J. H. M. (1986) Cross-reactivity of human and murine anti-DNA antibodies with heparan sulphate: the major glycosaminoglycan in glomerular basement membranes. J. Clin. Invest. 77, 1824-1830
    • (1986) J. Clin. Invest. , vol.77 , pp. 1824-1830
    • Faaber, P.1    Rijke, T.P.M.2    Van De Putte, L.B.A.3    Capel, P.J.A.4    Berden, J.H.M.5
  • 16
    • 0019364072 scopus 로고
    • Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA
    • Andrzejewski, C., Jr., Ranch, J., Lafer, E., Stollar, B. D., and Schwartz, R. S. (1981) Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA. J. Immunol. 126, 226-231
    • (1981) J. Immunol. , vol.126 , pp. 226-231
    • Andrzejewski Jr., C.1    Ranch, J.2    Lafer, E.3    Stollar, B.D.4    Schwartz, R.S.5
  • 17
    • 0020027426 scopus 로고
    • Binding specificity of a monoclonal anti-DNa antibody
    • Pisetsky, D. S., and Caster, S. A. (1982) Binding specificity of a monoclonal anti-DNA antibody. Mol. Immunol. 19, 645-650
    • (1982) Mol. Immunol. , vol.19 , pp. 645-650
    • Pisetsky, D.S.1    Caster, S.A.2
  • 19
    • 0021869622 scopus 로고
    • Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodies
    • Naparstek, Y., Duggan, D., Schattner, A., Madaio, M. P., Goni, F., Frangione, B., Stollar, B. D., Kabat, E. A., and Schwartz, R. S. (1985) Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodies. J. Exp. Med. 161, 1525-1538
    • (1985) J. Exp. Med. , vol.161 , pp. 1525-1538
    • Naparstek, Y.1    Duggan, D.2    Schattner, A.3    Madaio, M.P.4    Goni, F.5    Frangione, B.6    Stollar, B.D.7    Kabat, E.A.8    Schwartz, R.S.9
  • 21
    • 0022001632 scopus 로고
    • Binding of a monoclonal anti-DNa autoantibody to identical proteins present at the surface of several human cell types involved in lupus pathogenesis
    • Jacob, L., Lety, M.-A., Louvard, D., and Bach, J.-F. (1985) Binding of a monoclonal anti-DNA autoantibody to identical proteins present at the surface of several human cell types involved in lupus pathogenesis. J. Clin. Invest. 75, 315-317
    • (1985) J. Clin. Invest. , vol.75 , pp. 315-317
    • Jacob, L.1    Lety, M.-A.2    Louvard, D.3    Bach, J.-F.4
  • 22
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-DNA antibodies
    • Radic, M. Z., and Weigert, M. (1994) Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12, 487-520
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 23
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan, C., Adams, S., Stanik, V., and Datta, S. K. (1993) Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177, 1367-1381
    • (1993) J. Exp. Med. , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3    Datta, S.K.4
  • 24
    • 0027458695 scopus 로고
    • Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death)
    • Peitsch, M. C., Polzer, B., Stephan, H., Crompton, T., MacDonald, H. R., Mannherz, H. G., and Tschopp, J. (1993) Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12, 371-377
    • (1993) EMBO J. , vol.12 , pp. 371-377
    • Peitsch, M.C.1    Polzer, B.2    Stephan, H.3    Crompton, T.4    MacDonald, H.R.5    Mannherz, H.G.6    Tschopp, J.7
  • 27
    • 0023935405 scopus 로고
    • Comparative analysis of natural antibody specificities among hybridomas originating from spleen and peritoneal cavity of adult NZB and BALB/c mice
    • Kaushik, A., Lim, A., Poncet, P., Ge, X. R., and Dighiero, G. (1988) Comparative analysis of natural antibody specificities among hybridomas originating from spleen and peritoneal cavity of adult NZB and BALB/c mice. Scand. J. Immunol. 27, 461-471
    • (1988) Scand. J. Immunol. , vol.27 , pp. 461-471
    • Kaushik, A.1    Lim, A.2    Poncet, P.3    Ge, X.R.4    Dighiero, G.5
  • 28
    • 0000277131 scopus 로고
    • Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes
    • Baccala, R., Quang, T. V., Gilbert, M., Ternynck, T., and Avrameas, S. (1989) Two murine natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc. Natl. Acad. Sci. USA. 86, 4624-4628
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 4624-4628
    • Baccala, R.1    Quang, T.V.2    Gilbert, M.3    Ternynck, T.4    Avrameas, S.5
  • 30
    • 0026034708 scopus 로고
    • A novel class of anti-DNA antibodies identified in BALB/c mice
    • Shefner, R., Kleiner, G., Turken, A., Papazian, L., and Diamond, B. (1991) A novel class of anti-DNA antibodies identified in BALB/c mice. J. Exp. Med. 173, 287-296
    • (1991) J. Exp. Med. , vol.173 , pp. 287-296
    • Shefner, R.1    Kleiner, G.2    Turken, A.3    Papazian, L.4    Diamond, B.5
  • 31
    • 0028046317 scopus 로고
    • Usage of a novel class of germ-line Ig variable region gene for cationic anti-DNa autoantibodies in human lupus nephritis and its role for the development of the disease
    • Harada, T., Suzuki, N., Mizushima, Y., and Sakane, T. (1994) Usage of a novel class of germ-line Ig variable region gene for cationic anti-DNA autoantibodies in human lupus nephritis and its role for the development of the disease. J. Immunol. 153, 4806-4815
    • (1994) J. Immunol. , vol.153 , pp. 4806-4815
    • Harada, T.1    Suzuki, N.2    Mizushima, Y.3    Sakane, T.4
  • 32
    • 0025955528 scopus 로고
    • Mutation and selection during the secondary response to 2-phenyloxazolone
    • Rada, C., Gupta, S. K., Gherardi, E., and Milstein, C. (1991) Mutation and selection during the secondary response to 2-phenyloxazolone. Proc. Natl. Acad. Sci. USA 88, 5508-5512
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5508-5512
    • Rada, C.1    Gupta, S.K.2    Gherardi, E.3    Milstein, C.4
  • 33
    • 0023622462 scopus 로고
    • Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate: By products of an antigen-driven immune response?
    • Manser, T., Parhami-Seren, B., Margolies, M. N., and Gefter, M. L. (1987) Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate: by products of an antigen-driven immune response? J. Exp. Med. 166, 1456-1463
    • (1987) J. Exp. Med. , vol.166 , pp. 1456-1463
    • Manser, T.1    Parhami-Seren, B.2    Margolies, M.N.3    Gefter, M.L.4
  • 34
    • 0025978752 scopus 로고
    • Somatic mutations in the variable regions of a human IgG anti-double-stranded DNa autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus
    • van Es, J. H., Gmelig Meyling, F. H. J., van de Akker, W. R. M., Aanstoot, H., Derksen, R. H. W. M., and Logtenberg, T. (1991) Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J. Exp. Med. 173, 461-470
    • (1991) J. Exp. Med. , vol.173 , pp. 461-470
    • Van Es, J.H.1    Gmelig Meyling, F.H.J.2    Van De Akker, W.R.M.3    Aanstoot, H.4    Derksen, R.H.W.M.5    Logtenberg, T.6
  • 35
    • 0026080802 scopus 로고
    • Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB X NZW)F1 mice
    • Behar, S. M., Lustgarten, D. L., Corbel, S., and Scharff, M. D. (1991) Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB X NZW)F1 mice. J. Exp. Med. 173, 731-741
    • (1991) J. Exp. Med. , vol.173 , pp. 731-741
    • Behar, S.M.1    Lustgarten, D.L.2    Corbel, S.3    Scharff, M.D.4
  • 36
    • 0026761402 scopus 로고
    • Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB X NZW) F1 mice
    • Tillman, D. M., Jou, N.-T., Hill, R. J., and Marion, T. N. (1992) Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB X NZW) F1 mice. J. Exp. Med. 176, 761-779
    • (1992) J. Exp. Med. , vol.176 , pp. 761-779
    • Tillman, D.M.1    Jou, N.-T.2    Hill, R.J.3    Marion, T.N.4
  • 37
    • 0026612988 scopus 로고
    • Selection of immunoglobulin variable regions in autoimmunity to DNA
    • Marion, T. N., Tillman, D. M., Jou, N.-T., and Hill, R. J. (1992) Selection of immunoglobulin variable regions in autoimmunity to DNA. Immunol. Rev. 128, 123-149
    • (1992) Immunol. Rev. , vol.128 , pp. 123-149
    • Marion, T.N.1    Tillman, D.M.2    Jou, N.-T.3    Hill, R.J.4
  • 38
    • 0026534369 scopus 로고
    • Cationic residues in pathogenic anti-DNa autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene sub-family
    • O'Keefe, T. L., Datta, S. K., and Imanishi-Kari, T. (1992) Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene sub-family. Eur. J. Immunol. 22, 619-624
    • (1992) Eur. J. Immunol. , vol.22 , pp. 619-624
    • O'Keefe, T.L.1    Datta, S.K.2    Imanishi-Kari, T.3
  • 39
    • 0024325789 scopus 로고
    • Restriction fragment length polymorphism analysis of the Vκ locus in human lupus
    • Zouali, M., Madaio, M. P., Canoso, R. T., and Stollar, B. D. (1989) Restriction fragment length polymorphism analysis of the Vκ locus in human lupus. Eur. J. Immunol. 19, 1757-1760
    • (1989) Eur. J. Immunol. , vol.19 , pp. 1757-1760
    • Zouali, M.1    Madaio, M.P.2    Canoso, R.T.3    Stollar, B.D.4
  • 40
    • 0025784316 scopus 로고
    • Polymorphisms and haplotypes in the human immunoglobulin κ locus
    • Pargent, W., Schäble, K. F., and Zachau, H. G. (1991) Polymorphisms and haplotypes in the human immunoglobulin κ locus. Eur. J. Immunol. 21, 1829-1835
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1829-1835
    • Pargent, W.1    Schäble, K.F.2    Zachau, H.G.3
  • 42
    • 0027420392 scopus 로고
    • The human immunoglobulin κ locus. Characterization of the partially duplicated L regions
    • Huber, C., Huber, E., Lautner-Rieske, A., Schäble, K. F., and Zachau, H. G. (1993) The human immunoglobulin κ locus. Characterization of the partially duplicated L regions. Eur. J. Immunol. 23, 2860-2867
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2860-2867
    • Huber, C.1    Huber, E.2    Lautner-Rieske, A.3    Schäble, K.F.4    Zachau, H.G.5
  • 44
    • 0029861299 scopus 로고    scopus 로고
    • Characterization of a germline Vκ gene encoding cationic anti-DNa antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus
    • Suzuki, N., Harada, T., Mihara, S., and Sakane, T. (1996) Characterization of a germline Vκ gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus. J. Clin. Invest. 98, 1843-1850
    • (1996) J. Clin. Invest. , vol.98 , pp. 1843-1850
    • Suzuki, N.1    Harada, T.2    Mihara, S.3    Sakane, T.4
  • 45
    • 0027428398 scopus 로고
    • Expressed human immunoglobulin κ genes and their hypermutation
    • Klein, R., Jaenichen, R., and Zachau, H. G. (1993) Expressed human immunoglobulin κ genes and their hypermutation. Eur. J. Immunol. 23, 3248-3271
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3248-3271
    • Klein, R.1    Jaenichen, R.2    Zachau, H.G.3
  • 46
    • 0028017577 scopus 로고
    • Production and nucleotide sequence of an inhibitory human IgM autoantibody directed against platelet glycoprotein Ia/IIa
    • Deckmyn, H., Zhang, J., Van Houtte, E., and Vermylen, J. (1994) Production and nucleotide sequence of an inhibitory human IgM autoantibody directed against platelet glycoprotein Ia/IIa. Blood 84, 1968-1974
    • (1994) Blood , vol.84 , pp. 1968-1974
    • Deckmyn, H.1    Zhang, J.2    Van Houtte, E.3    Vermylen, J.4
  • 47
    • 0029153488 scopus 로고
    • Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: Evidence for CDR2H mutations and CDR3H motifs
    • Rioux, J. D., Zdarsky, E., Newkirk, M. M., and Rauch, J. (1995) Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: evidence for CDR2H mutations and CDR3H motifs. Mol. Immunol. 32, 683-696
    • (1995) Mol. Immunol. , vol.32 , pp. 683-696
    • Rioux, J.D.1    Zdarsky, E.2    Newkirk, M.M.3    Rauch, J.4
  • 48
    • 0025810917 scopus 로고
    • Nucleotide sequence of the human autoantibody 2E7 specific for the platelet integrin IIb heavy chain
    • Kunicki, T. J., Annis, D. S., Gorski, J., and Nugent, D. J. (1991) Nucleotide sequence of the human autoantibody 2E7 specific for the platelet integrin IIb heavy chain. J. Autoimmun. 4, 433-446
    • (1991) J. Autoimmun. , vol.4 , pp. 433-446
    • Kunicki, T.J.1    Annis, D.S.2    Gorski, J.3    Nugent, D.J.4
  • 49
    • 0028917925 scopus 로고
    • Domain interactions and antigen binding of recombinant anti-Z-DNA antibody variable domains. the role of heavy and light chains measured by surface plasmon resonance
    • Polymenis, M., and Stollar, B. D. (1995) Domain interactions and antigen binding of recombinant anti-Z-DNA antibody variable domains. The role of heavy and light chains measured by surface plasmon resonance. J. Immunol. 154, 2198-2208
    • (1995) J. Immunol. , vol.154 , pp. 2198-2208
    • Polymenis, M.1    Stollar, B.D.2
  • 51
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee, D. A., and Bürki, K. (1989) Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature (London) 337, 562-566
    • (1989) Nature (London) , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Bürki, K.2
  • 53
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993) Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 54
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S. L., Russell, D. M., and Nemazee, D. (1993) Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 55
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M. Z., Erikson, J., Litwin, S., and Weigert, M. (1993) B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177, 1165-1173
    • (1993) J. Exp. Med. , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 56
    • 0029807629 scopus 로고    scopus 로고
    • B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen
    • Lang, J., Jackson, M., Teyton, L., Brunmark, A., Kane, K., and Nemazee, D. (1996) B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen. J. Exp. Med. 184, 1685-1697
    • (1996) J. Exp. Med. , vol.184 , pp. 1685-1697
    • Lang, J.1    Jackson, M.2    Teyton, L.3    Brunmark, A.4    Kane, K.5    Nemazee, D.6
  • 57
    • 0028856335 scopus 로고
    • Immature B cells from human and mouse bone marrow can change their surface light chain expression
    • Ghia, P., Gratwohl, A., Signer, E., Winkler, T. H., Melchers, F., and Rolink, A. G. (1995) Immature B cells from human and mouse bone marrow can change their surface light chain expression. Eur. J. Immunol. 25, 3108-3114
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3108-3114
    • Ghia, P.1    Gratwohl, A.2    Signer, E.3    Winkler, T.H.4    Melchers, F.5    Rolink, A.G.6
  • 58
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
    • Chen, C., Nagy, Z., Prak, E. L., and Weigert, M. (1995) Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3, 747-755
    • (1995) Immunity , vol.3 , pp. 747-755
    • Chen, C.1    Nagy, Z.2    Prak, E.L.3    Weigert, M.4
  • 59
    • 0028358692 scopus 로고
    • Human lupus anti-DNA autoantibodies undergo essentially primary Vκ gene rearrangements
    • Bensimon, C., Chastagner, P., and Zouali, M. (1994) Human lupus anti-DNA autoantibodies undergo essentially primary Vκ gene rearrangements. EMBO J. 13, 2951-2962
    • (1994) EMBO J. , vol.13 , pp. 2951-2962
    • Bensimon, C.1    Chastagner, P.2    Zouali, M.3
  • 61
    • 0027943184 scopus 로고
    • Light chain editing in κ-deficient animals: A potential mechanism of B cell tolerance
    • Prak, E. L., Trounstine, M., Huszar, D., and Weigert, M. (1994) Light chain editing in κ-deficient animals: a potential mechanism of B cell tolerance. J. Exp. Med. 180, 1805-1815
    • (1994) J. Exp. Med. , vol.180 , pp. 1805-1815
    • Prak, E.L.1    Trounstine, M.2    Huszar, D.3    Weigert, M.4
  • 62
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K. (1996) Clonal selection and learning in the antibody system. Nature (London) 381, 751-758
    • (1996) Nature (London) , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 64
    • 0028961264 scopus 로고
    • Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
    • Cyster, J. G., and Goodnow, C. C. (1995) Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2, 13-24
    • (1995) Immunity , vol.2 , pp. 13-24
    • Cyster, J.G.1    Goodnow, C.C.2
  • 65
    • 0029014435 scopus 로고
    • Antigen-induced B-cell death and elimination during germinal-centre immune responses
    • Shokat, K. M., and Goodnow, C. C. (1995) Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature (London) 375, 334-338
    • (1995) Nature (London) , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 66
    • 0030023652 scopus 로고    scopus 로고
    • Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
    • Cyster, J. G., Healy, J. I., Kishihara, K., Mak, T. W., Thomas, M. L., and Goodnow, C. C. (1996) Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature (London) 381, 325-328
    • (1996) Nature (London) , vol.381 , pp. 325-328
    • Cyster, J.G.1    Healy, J.I.2    Kishihara, K.3    Mak, T.W.4    Thomas, M.L.5    Goodnow, C.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.