Particle size measurements for the Space-Chamber metered dose inhaler holding chamber compared with Aerochamber and metered dose inhaler alone

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 10, Issue 3, 1997, Pages 213-219

  Finlay, W H ^a   Zuberbuhler, P ^b   Mandl, M ^c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Aerosol; Holding chamber; MDI; Particle size; Spacer

Indexed keywords

BECLOMETASONE; SALBUTAMOL;

AEROSOL; ARTICLE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; INHALATION; METERED DOSE INHALER; PARTICLE SIZE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0030830098     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1997.10.213     Document Type: Article

References (7)

1. US Pharmacopeia. 1995. Physical test and determinations. Aerosols. United States Pharmacopeia 23:1760-1767.
2. Dalby, R.J., L. Ziegler, S. Somaraju, M. Tsoukleris, and J. Teeter. 1996. The effect of time delays between inhaler actuation and onset of inhalation on the dose of albuterol exiting optihaler, Aec rochamber, and aerosol cloud enhancer (ACE) spacers. In R.N. Dalby, P.R. Byron, and S.J. Farr, eds. Respiratory Drug Delivery V. Buffalo Grove, IL: Interpharm Press, 324-326.
3. Newman, S.P. 1993. Therapeutic aerosol deposition in man. In F. Moren, M.B. Dolovich, M.T. Newhouse, and S.P. Newman, eds. Aerosols in Medicine. Principles, Diagnosis and Therapy. Elsevier, Amsterdam, 375-399.
4. Ahrens, R., C. Lux, T. Bahl, and S.-H. Han. 1995. Choosing the metered-dose inhaler spacer or holding chamber that matches the patient's need: Evidence that the specific drug being delivered is an important consideration. J. Allergy Clin. Immunol. 96:288-294.
5. Dolovich, M., C. Chambers, M. Mazza, and M.T. Newhouse. 1992. Relative efficiency of four metered dose inhalers (MDI) holding chambers (HC) compared to albuterol MDI. Presented at the American Lung Association and American Thoracic Society 1992 International Conference Symposium on Aerosol Delivery Systems, May 17-20, 1992, Miami Beach, FL.
6. Mitchell, J.P., and M.W. Nagel. 1996. Comparison of beclomethasone diproprionate delivery using a large and small holding chamber: In vitro measurements. Chest 199:S1104.
7. O'Callaghan, C., M. Cant, and C. Robertson. 1994. Delivery of beclomethasone diproprionate from a spacer device: What dose is available for inhalation? Thorax 49:961-964.