Treatment with GAD65 or BSA does not protect against diabetes in BB rats

Autoimmunity

Volumn 25, Issue 3, 1997, Pages 129-138

  Petersen, Jacob Sten ^a,e   Mackay, Peter ^b   Plesner, Annette ^a   Karlsen, Allan ^c   Gotfredsen, Carsten ^b   Verland, Sten ^d   Michelsen, Birgitte ^a   Dyrberg, Thomas ^b  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c STENO DIABETES CENTER   (Denmark)

^d Møllegaard Breed Res C   (Denmark)

^e ZYMOGENETICS INC   (United States)

Author keywords

BB rats; BSA and T cell proliferation; GAD65; Insulitis; Tolerization

Indexed keywords

BOVINE SERUM ALBUMIN; CELL ANTIGEN; GLUTAMATE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PANCREAS ISLET CELL; PATHOGENESIS; PROTECTION; PROTEIN EXPRESSION; RAT;

EID: 0030829772     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939709008019     Document Type: Article

References (30)

1. Bach, J. F. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 1994: 15: 516-542.
2. Leslie, R. D., Elliott, R. B. Early enviromental events as cause of IDDM. Evidence and implications. Diabetes 1994: 43: 843-850.
3. Bækkeskov, S., Aanstoot, H.-J., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., De-Camilli, P. Identification of the 64K autoantigen in insulin dependant diabetes as the GABA-synthesising enzyme glutamic acid decarboxylase. Nature 1990: 347: 151-156.
4. Atkinson, M. A., Kaufmann, D. L., Campbell, L., Gibbs, K. A., Shah, S. C., Bu, D. F., Erlander, M. G., Tobin, A. J., Maclaren, N. K. Response of peripheralblood monouclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 1992: 339: 458-458.
5. Kaufman. D. L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G. S. P., Robinson, P., Atkinson, M. A., Sercarz, E. E., Tobin, A. J., Lehmann, P. V. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1994: 366: 69-72.
6. Tisch, R., Yang, X.-D., Singer, S. M., Liblau, R. S., Fugger, L., McDevitt, H. O. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1994: 366: 72-75.
7. Karjalainen, J., Martin, J. M., Knip, M., Ilonen, J., Robinson, B. H., Savilahti, E., Akerblom, H. K., Dosch, HM. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N. Engl. Med. 1992: 327: 302-307.
8. Karjalainen, J., Cheung, R., Vandermeulen, J. Martin, J. M., Knip, M., Dosch, H. M. T-cell proliferation response against bovine serum albumin (BSA) follows the natural course and is restricted to the linear ABBOS sequence in insulin dependent diabetes mellitus. J. Autoimmun. 1993: 15 suppl. 1: 62abstract.
9. Petersen, J. S., Karlsen, A. E., Markholst, H., Worsaae, A., Dyrberg, T., Michelsen, B. Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice. Diabetes 1994: 43: 1478-1484.
10. Elliott, J. F., Qin, H. Y., Bhatti, S., Smith, D. K., Singh, R. K., Dillon, T., Lauzon, J., Singh, B. Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes 1994: 43: 1494-1499.
11. Feutren, G., Papoz, L., Assan, R., Vialettes, B., Karsenty, G., Vexiau, P., Rostu, H. D., Rodier, H., Sirmai, J., Lallemand, A., Bach, J. F. Cyclosporin increases the rate and length of remission in insulin-dependent diabetics of recent onset: results of a multicentre double-blind trail. Lancet 1986: 2: 119-123.
12. The Canadian-European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention: association of 1 yr of cyclosporin treatment with enhanced insulin secretion. Diabetes 1988: 37: 1574-1582.
13. Mihatsch, M., Thiel, G., Ryffel, B. Morphology of cyclosporin nephropathy. Prog. Allergy 1986: 38: 447-65.
14. Hashimoto, L., Habita, C., Berssi, J. P., Delepine, M., Besse, C., Cambon-Thomsen, A., Deschamps, I., Rotter, J. I., Djoulah, S., James M. R., Todd, J. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 1994: 371: 161-164.
15. Scott, J. The spontaneously diabetic BB rat: sites of the defects leading to autoimmunity and diabetes mellitus. Curr. Top. Microbiol. Immunol. 1990: 156: 1-14.
16. Hanafusa, T., Tarui, S. Immune pathogenesis of diabetes in the nonobese diabetic mouse. Curr. Top. Microbiol. Immunol. 1990: 156: 15-26.
17. 65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay. Diabetes 1994: 43: 459-467.
18. Atar, D., Dyrberg, T., Michelsen, B., Karlsen, A., Kofod, H., Mølvig, J., Lernmark, Å. Site-specific antibodies distinguish single amino acid substitutions in position 57 in HLA-DQ β-chain alleles associated with insulin-dependent diabetes. J. Immunol. 1989: 143: 533-538.
19. Mclnerney, M. F., Pek, S. B., Thomas, D. W. Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvent in NOD mice. Diabetes 1991: 40: 715-725.
20. Wang, Y., McDuffie, M., Nomikos, I. N., Hao, L., Lafferty, K. J. Effect of cyclosporin on immunologically mediated diabetes in nonobese diabetic mice. Transplantation 1988: 46: 101-106.
21. Yamada, K., Nonaka, K., Hanafusa, T., Miyazaki, A., Toyoshima, H., Tarui, S. Prevention and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. Diabetes 1982: 31: 749-753.
22. Rapoport, M. J., Jaramillo, A., Zipris, D., Lazarus, A. H., Serreze, D. V., Leither, E. H., Cyopick, P., Danska, J. S., Delovitch, T. L. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 1993: 178: 87-99.
23. Atkinson, M. A., Maclaren, N. K., Luchetta, R. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 1990: 39: 933-937.
24. Elias, D., Markovits, D., Reshef, T., Van Der Zee, R., Cohen, I. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shockprotein. Proc. Natl. Acad. Sci. USA 1990: 87: 1576-1580.
25. Posselt, A. M., Barker, C. F., Friedman, A. L., Naji, A. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 1992: 256: 1321-1324.
26. Plesner, A., Worsaae, A., Michelsen, B., Dyrberg, T., Petersen, J. S. High levels of T-cell responses to GAD65 in the NOD mouse compared to non-diabetic strains of mice. Diabetologia 1994: 37, 358 abstract supplement 1.
27. Bækkeskov, S., Dyrberg T, Lernmark Å. Autoantibodies to a 64kD islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science 1984: 224: 1348-1350.
28. Luhder, F., Woltanski, K. P., Hamann, J., Kloting, I., Ziegler, B., Ziegler, M. Detection of antibodies against both isoforms of glutamate decarboxylase in BB/OK rats by western blotting and immuno trapping enzyme activity assay. Diabetes Res. 1992: 20: 97-107.
29. Davenport, C., Lovell, H., James, R. F. L., Todd, I. Brain-reactive autoantibodies in BB/d rats do not recognize glutamic acid decarboxylase. Clin. Exp. Immunol. 1995: 101: 127-135.
30. Keller, R. J., Eisenbarth, G. S., Jackson, R, A. Insulin prophylaxis in individuals at high risk of type 1 diabetes. Lancet 1993: 341: 927-928.