Targeting tumor cell destruction with CD64-directed bispecific fusion proteins

Cancer Immunology Immunotherapy

Volumn 45, Issue 3-4, 1997, Pages 124-127

  Graziano, Robert F ^a   Goldstein, Joel ^a   Sundarapandiyan, Karuna ^a   Somasundaram, Chezian ^a   Keler, Tibor ^a   Deo, Yashwant M ^a  

^a MEDAREX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; CD64 ANTIGEN; HYBRID PROTEIN;

ANTIBODY PRODUCTION; ARTICLE; CANCER IMMUNOTHERAPY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TUMOR CELL DESTRUCTION;

ANTIBODIES, BISPECIFIC; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; CARRIER PROTEINS; EPIDERMAL GROWTH FACTOR; GENETIC VECTORS; GLYCOPROTEINS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; NEUREGULIN-1; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030829615     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050413     Document Type: Article

References (27)

1. Anderson CA, Guyre PM, Whitin JC, Ryan DH, Looney RJ, Fanger MW (1986) Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes: antibody characterization and induction of superoxide production in a monocyte cell line. J Biol Chem 261:12856
2. Bacus SS, Gudkov AV, Zelnick CR, Chin D, Stern R, Stancovski I, Peles E, Ben-Baruch N, Farbstein H, Lupu R, Wen D, Sela M, Yarden Y (1993) Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors. Cancer Res 53:5251
3. Barnes DW (1982) Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture. J Cell Biol 93:1
4. Carter P, Kelley RF, Rodrigues ML, Snedecor B, Covarrubias M, Velligan MD, Wong WLT, Rowland AM, Kotts CE, Carver ME, Yang M, Bourell JH, Shepard HM, Henner D (1992) High level Escherichia coli expression and production of a bivalent humanized antibody fragment. Biotechnol 10:163
5. Deo YM, Graziano RF, Repp R, Winkel JGJ van de (1997) Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies. Immunol Today 18:127
6. Gilles SD, Wesolowski JS, Lo K-M (1991) Targeting human cytotoxic T lymphocytes to kill heterologous epidermal growth factor receptor-bearing cells. J Immunol 146:1067
7. Goldstein J, Matsueda GR, Shaw S-Y (1996) A chimeric streptokinase with unexpected fibrinolytic selectivity. Thromb Haemost 76:429
8. Goldstein J, Graziano RF, Sundarapandiyan K, Somasundaram C, Deo YM (1997) Cytolytic and cytostatic properties of an antihuman FcγRI (CD64) X epidermal growth factor bispecific fusion protein. J Immunol 158:872
9. Gosselin EJ, Wardwell K, Gosselin DR, Alter N, Fisher JL, Guyre PM (1992) Enhanced antigen presentation using human Fcγ receptor (monocyte/macrophage)-specific immunogens. J Immunol 149:3477
10. Graziano RF, Tempest PR, White P, Keler T, Deo YM, Ghebremariam H, Coleman K, Pfefferkorn LC, Fanger MW, Guyre PM (1995) Construction and characterization of a humanized anti-γ-Ig receptor type I (FcγRI) monoclonal antibody. J Immunol 155:4996
11. Graziano RF, Erbe DV, Fanger MW (1989) The mechanisms of antibody-dependent killing mediated by lymphoid and myeloid cells are distinct based on different divalent cation requirements. J Immunol 143:3894
12. Guyre PM, Graziano RF, Vance BA, Morganelli PM, Fanger MW (1989) Monoclonal antibodies that bind to distinct epitopes on FcγRI are able to trigger receptor function. J Immunol 143: 1650
13. Heijnen IA, van Vugt MJ, Fanger NA, Graziano RF, de Wit TP, Hofhuis FM, Guyre PM, Capel PJ, Verbek JS, Winkel JG van de (1996) Antigen targeting to myeloid-specific human FcγRI/CD64 triggers enhanced antibody responses in transgenic mice. J Clin Invest 97:331
14. 2-phase to mitosis: a receptor-mediated phenomenon in various cells. Cancer Res 50:7932
15. Kraus MH, Issing W, Miki T, Popescu MC, Aaronson SA (1989) Isolation and characterization of ERBB3, a third member of the ERBB/Epidermal growth factor family: evidence for overexpression in a subset of human mammary tumours. Proc Natl Acad Sci USA 86: 9193
16. Liu C, Goldstein J, Graziano RF, He J, O'Shea JK, Deo YM, Guyre PM (1996) FcγRI-targeted fusion proteins result in efficient presentation by human monocytes of antigenic and antagonist T cell epitopes. J Clin Invest 98:2001
17. Liu MA, Nussbaum SR, Eisen HN (1988) Hormone conjugated with antibody to CD3 mediates cytotoxic T cell lysis of human melanoma cells. Science 239:395
18. Lofts FJ, Gullick WJ (1992) Breast cancer: cellular and molecular biology. Kluwer Academic Publishers, Boston, Mass
19. MacLeod CL, Luk A, Castagnola J, Cronin M, Mendelsohn J (1986) EGF induces cell cycle arrest of A431 human epidermoid carcinoma cells. J Cell Physiol 127:175
20. Owens O J, Stewart C, Brown I, Leake RE (1991) Epidermal growth factor receptors (EFGR) in human ovarian cancer. Brit J Cancer 64:907
21. Plowman GD, Culouscou JM, Whitney GS, Green JM, Carlton GW, Foy L, Neubauer MG, Shoyab M (1993) Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA 90: 1746
22. 2 formation in Escherichia coli and for improved in vivo stability. J Immunol 151:6954
23. Shen L, Guyre PM, Fanger MW (1987) Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG. J Immunol 139:534
24. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177
25. Stockmeyer B, Valerius T, Repp R, Heijnen IAFM, Buhring HJ, Deo YM, Kalden JR, Gramatzki M, Van de Winkel JGJ (1997) Preclinical studies with FcgR bispecific antibodies and G-CSF primed neutrophils as effector cells against HER2/neu overexpressing breast cancer. Cancer Res 57:696
26. Tikannen S, Helin H, Isola J, Joensuu H (1992) Prognostic Significance of HER-2 oncoprotein expression in breast cancer: a 30 year follow-up. J Clin Oncol 10:1044
27. Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JGJ (1993) Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy. Blood 82:93121