Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: An open trial

Brain and Development

Volumn 19, Issue 7, 1997, Pages 459-463

  Coppola, Giangennaro ^a   Terraciano, Annamaria Maddalena ^b   Pascotto, Antonio ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

Author keywords

Adverse events; Antiepileptic drugs; Refractory epilepsy; Seizure decrease; Vigabatrin

Indexed keywords

VIGABATRIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL TRIAL; DROWSINESS; DRUG EFFICACY; DRUG RESISTANCE; DRUG TOLERANCE; EPILEPSY; EXCITABILITY; FEMALE; FOCAL EPILEPSY; HUMAN; INFANTILE SPASM; MAJOR CLINICAL STUDY; MALE; WEIGHT GAIN;

ADOLESCENT; ADULT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; EPILEPSIES, PARTIAL; EPILEPSY; EPILEPSY, GENERALIZED; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MYOCLONUS; SPASMS, INFANTILE; VIGABATRIN;

EID: 0030829132     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0387-7604(97)00063-6     Document Type: Article

References (24)

1. Gale K. GABA in epilepsy: the pharmacologic basis. Epilepsia. 30(Suppl. 3):1989;S1-11.
2. Grant S.M., Heel R.C. Vigabatrin - a review of its pharmacodynamic and pharmakokinetic properties, and therapeutic potential in epilepsy and disorders of motor control. Studies in children. Drugs. 41(6):1991;912-913.
3. Dulac O., Chiron C., Luna D.et al. Vigabatrin in childhood epilepsy. J Child Neurol. 6(Suppl 2):1991;S30-33.
4. Dam M. Vigabatrin in refractory epilepsy in adults and its application in children. J Child Neurol. 6(Suppl 2):1991;S25-29.
5. Chiron C., Dulac O., Beaumont D.et al. Therapeutic trial of vigabatrin in refractory infantile spasm. J Child Neurol. 6(Suppl 2):1991;S52-59.
6. Commission on Classification and Terminology of the International League against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22:489-501.
7. Commission on Classification and Terminology of the International League against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389-399.
8. Livingston J.H., Beaumont D., Arzimanoglou A.A., Aicardi J. Vigabatrin in the treatment of epilepsy in children. Br J Clin Pharmacol. 27(Suppl 1):1989;109-112S.
9. Luna D., Dulac O., Pujot N., Beaumont D. Vigabatrin in the treatment of childhood epilepsies: a single-blind placebo-controlled study. Epilepsia. 30:1989;430-437.
10. Uldall P., Alving J., Gram L., Beck S. Vigabatrin in pediatric epilepsy - an open study. J Child Neurol. 6(Suppl 2):1991;S38-44.
11. Wong V. Open label trial with vigabatrin in children with intractable epilepsy. Brain Dev. 17:1995;249-252.
12. Matilainen R., Pitkanen A., Ruutiainen T., Merveala E., Piekkinen P. Vigabatrin in epilepsy in mentally retarded patients. Br J Clin Pharmacol. 27(Suppl 1):1989;113-118S.
13. Appleton RE. The role of vigabatrin in the management of infantile epileptic syndromes. Neurology 1993;43(Suppl 5):S21-23.
14. Vles J.S.H., Van der Hayden A.M.H.G., Ghijs A., Troost J. Vigabatrin in the treatment of infantile spasms. Neuropediatrics. 24:1993;230-231.
15. Buti D., Rota M., Lini M.et al. First-line monotherapy with vigabatrin in infantile spasms: long-term clinical and EEG evolution in 12 patients. Epilepsia. 36(Suppl. 3):1995;S102.
16. Aicardi J, Chairman and the Coordinating Peer Review Group, The European IS Vigabatrin Group. European experience with use of vigabatrin as first-line monotherapy in infantile spasms. Epilepsia 1995;36 (Suppl. 3):S102.
17. Appleton R.E. Vigabatrin in the management of generalized seizures in children. Seizure. 4:1995;45-48.
18. Lortie A., Chiron C., Mumford J., Dulac O. The potential of increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin. Neurology. 43(Suppl 5):1993;S24-27.
19. Gibbs J.M., Appleton R.E., Rosenbloom L. Vigabatrin in intractable childhood epilepsy: a retrospective study. Pediatr Neurol. 8:1992;338-340.
20. Gillham R.A., Blacklaw J., Makee P.J., Brodie M.J. Effect of vigabatrin on sedation and cognitive function in patients with refractory epilepsy. J Neurol Neurosurg Psychiatry. 56:1993;1271-1275.
21. Herranz J.L., Arteaga R., Farr I.N.et al. Dose-response study of vigabatrin in children with refractory epilepsy. J Child Neurol. 6(Suppl 2):1991;S45-51.
22. Pitkanen A., Ylinen A., Matilainen R.et al. Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study. Arch Neurol. 50:1993;24-29.
23. Browne J.R., Mattson R.H., Penry J.K.et al. Multicenter long-term safety and efficacy study of vigabatrin for refractory complex partial seizures: an update. Neurology. 41:1991;363-364.
24. Tartara A., Manni R., Galimberti C.A., Mumford J.P., Iudice A., Perucca E. Vigabatrin in the treatment of epilepsy: a long-term follow-up study. J Neurol Neurosurg Psychiatry. 52:1989;467-471.